249 research outputs found
Session 1.1: Texas Labor Issues
No full textModerator: Dr. Mark Popowski, Collin College—Frisco “‘Fighting for Justice’: Teamsters, Human Rights, and a Renewal of Working-Class Activism, 1992-2000,” Dr. Ryan Pettengill, Collin College—Wylie “The Resiliency of Texas\u27s Economy,” Dr. Lishan Desta, Collin College—McKinney “The Grange, the Greenback Party, and Lawlessness in 1870s Texas,” Lucius Seger, Texas Christian Universit
sj-docx-1-tpx-10.1177_01926233221132747 – Supplemental material for Toxicologic Pathology Forum*: A Roadmap for Building State-of-the-Art Digital Image Data Resources for Toxicologic Pathology in the Pharmaceutical Industry
No full textSupplemental material, sj-docx-1-tpx-10.1177_01926233221132747 for Toxicologic Pathology Forum*: A Roadmap for Building State-of-the-Art Digital Image Data Resources for Toxicologic Pathology in the Pharmaceutical Industry by Xing-Yue Ge, Juergen Funk, Tom Albrecht, Merima Birkhimer, Moritz Gilsdorf, Matthew Hayes, Fangyao Hu, Pierre Maliver, Mark McCreary, Trung Nguyen, Fernando Romero-Palomo, Shanon Seger, Reina N. Fuji, Vanessa Schumacher and Ruth Sullivan in Toxicologic Pathology</p
Some Fourier inequalities for orthogonal systems in Lorentz–Zygmund spaces
No full textA number of classical inequalities and convergence results related to Fourier coefficients with respect to unbounded orthogonal systems are generalized and complemented. All results are given in the case of Lorentz–Zygmund spaces. © 2019, The Author(s).We thank the referees and Professors Dag Lukkasson and Annette Meidell for some good advice which improved the final version of the paper. Moreover, the first author is grateful for the support of this work given by the Russian Academic Excellence Project (agreement no. 02.A03.21.0006 of August 27, 2013, between the Ministry of Education and Science of the Russian Federation and Ural Federal University)
Saga of the Whispering Hills - 075
No full textPhotograph - Cast members Reg Netterville, Mike Milne, Olga Ross and Joe Ladouceur singing "Come Dance with Me Joe Seger". Saga of the Whispering Hills, presented by the Athabasca Players for the 75th Anniversary of Athabasca, Albert
Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene
No full textG protein-coupled receptor regulation of gene transcription primarily occurs through the phosphorylation of transcription factors by MAPKs. This requires transduction of an activating signal via scaffold proteins that can ultimately determine the outcome by binding signaling kinases and adapter proteins with effects on the target transcription factor and locus of activation. By investigating these mechanisms, we have elucidated how pituitary gonadotrope cells decode an input GnRH signal into coherent transcriptional output from the LH beta-subunit gene promoter. We show that GnRH activates c-Src and multiple members of the MAPK family, c-Jun NH2-terminal kinase 1/2, p38MAPK, and ERK1/2. Using dominant-negative point mutations and chemical inhibitors, we identified that calcium-dependent proline-rich tyrosine kinase 2 specifically acts as a scaffold for a focal adhesion/cytoskeleton-dependent complex comprised of c-Src, Grb2, and mSos that translocates an ERK-activating signal to the nucleus. The locus of action of ERK was specifically mapped to early growth response-1 (Egr-1) DNA binding sites within the LH beta-subunit gene proximal promoter, which was also activated by p38MAPK, but not c-Jun NH2-terminal kinase 1/2. Egr-1 was confirmed as the transcription factor target of ERK and p38MAPK by blockade of protein expression, transcriptional activity, and DNA binding. We have identified a novel GnRH-activated proline-rich tyrosine kinase 2-dependent ERK-mediated signal transduction pathway that specifically regulates Egr-1 activation of the LH beta-subunit proximal gene promoter, and thus provide insight into the molecular mechanisms required for differential regulation of gonadotropin gene expression
Transformation of the nuclear genome of Galdieria sulphuraria 5587.1 and ketocarotenoid accumulation
No full textThe red alga Galdieria sulphuraria is found in acidic hot springs (pH ~2, ~42°C), has a small genome of 13.7 Mbp, and has a thick outer cell wall. It holds promising biotechnological potential for its ability to consume diverse carbon sources for inexpensive waste conversion into high-value biomass. A sexual cycle in Galdieria partita was recently described, whereby pH controls conversion to haploid cells without cell walls, which enables genetic transformation via homologous recombination (Hirooka et al., 2022). G. sulphuraria has a limited carotenoid profile with no α-carotenes. To enhance its economic potential, we tested whether strain 5587.1 could be genetically transformed and used the heterologous expression of Chlamydomonas β- carotene ketolase (CrBKT) as a reporter (Seger et al., 2023, Perozeni et al. 2020).KAUST Baseline research funding
KAUST Opportunity Fund Grant 557
Saga of the Whispering Hills - 103
No full textPhotograph - Cast members Ken Knight (Joe Boyle), Olga Ross (Mrs. Joe Bird), Helen Hyde (Mrs. Wood), Reg Nettterville (Captain Buff Barker), Orest Muzyka (Captain Tremble), Mike Milne (Jim Cornwall), Joe Ladouceur (Joe Seger). Bob Garton (Mr. Cameron), Kathy Topola (Miss Cameron), Dennis MacNeil (Mr. Sawle) and Jessica Hendrigan (Mrs. Sawle) singing "Union Hotel". Saga of the Whispering Hills, presented by the Athabasca Players for the 75th Anniversary of Athabasca, Albert
Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase pathway
No full textProstaglandin E(2) (PGE(2)) has been shown to modulate angiogenesis and tumour progression via the E-series prostanoid-2 (EP2) receptor. Endometrial adenocarcinomas may be exposed to endogenous PGE(2) and exogenous PGE(2), present at high concentration in seminal plasma
Interaction-aware Pedestrian Trajectory Prediction using Monocular Video in Automated Driving
No full textPedestrian trajectory prediction is essential for developing safe autonomous driving systems. Such trajectories depend on various contextual cues, among which surrounding objects. This work proposes the first pedestrian trajectory prediction method in the 2D on-board domain that models interactions between the pedestrian and surrounding static- and dynamic- contextual objects using a graph-based approach. Our two-stream model separately encodes past motion history and interactions. The encoded information from both streams is fused and decoded to generate future pedestrian trajectories. The interactions are modeled using spatial graphs, which are temporally connected using a Gated Recurrent Unit. The graph nodes represent the pedestrian and contextual objects, and the edges represent the interaction importance between nodes. In experiments on the PIE and JAAD_full dataset, it is shown that our graph-based interaction-aware trajectory prediction method outperforms all considered baselines on nearly all metrics. Moreover, the performance gain on JAAD_full is most significant for the close-by pedestrians. Finally, modeling the interactions with all considered contextual objects, i.e. vehicles, crosswalks, and traffic lights, improves trajectory prediction performance most compared to only using a subset of these objects.Mechanical Engineering | Vehicle Engineerin
Birmingham News sleeve BN0056264
No full textSouthern Baptist Sunday School Board with historical marker at O'Brien Opera site / Southern Baptist Sunday School Board officials place a historical marker where O'Brien Opera House once stood, the site of the 1891 Southern Baptist Convention, which established the Sunday school board / Corner of 1st Avenue North and 19th Street / Lloyd Felder - president / Reverend Douglas Seger - pastor Roebuck Park Baptist Church / Dr. Levin Parker Central Park Baptist Church youth minister / Headmaster Central Park Christian School / [Work order included
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