409 research outputs found

    College of Engineering Drexel E-Repository and Archive (iDEA)

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    www.library.drexel.edu The following item is made available as a courtesy to scholars by the author(s) and Drexel University Library and may contain materials and content, including computer code and tags, artwork, text, graphics, images, and illustrations (Material) which may be protected by copyright law. Unless otherwise noted, the Material is made available for non profit and educational purposes, such as research, teaching and private study. For these limited purposes, you may reproduce (print, download or make copies) the Material without prior permission. All copies must include any copyright notice originally included with the Material. You must seek permission from the authors or copyright owners for all uses that are not allowed by fair use and other provisions of the U.S. Copyright Law. The responsibility for making an independent legal assessment and securing any necessary permission rests with persons desiring to reproduce or use the Material. Please direct questions to [email protected] F M Sasoglu, A J Bohl and B E Layton Microbeam array for nN force measurement Design and microfabrication a high-aspect-ratio PDMS microbeam array for parallel nanonewton force measurement and protein printin

    sj-pdf-1-jcb-10.1177_0271678X211072391 - Supplemental material for Venous cerebral blood flow quantification and cognition in patients with sickle cell anemia

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    Supplemental material, sj-pdf-1-jcb-10.1177_0271678X211072391 for Venous cerebral blood flow quantification and cognition in patients with sickle cell anemia by Hanne Stotesbury, Patrick W Hales, Melanie Koelbel, Anna M Hood, Jamie M Kawadler, Dawn E Saunders, Sati Sahota, David C Rees, Olu Wilkey, Mark Layton, Maria Pelidis, Baba PD Inusa, Jo Howard, Subarna Chakravorty, Chris A Clark and Fenella J Kirkham in Journal of Cerebral Blood Flow & Metabolism</p

    Birth and evolution of the discipline of Physics in secondary education: an analysis from the theory of David Layton

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    Tese (Doutorado)Este texto apresenta uma pesquisa que analisou a gênese e a evolução da disciplina de Física no Brasil à luz da teoria de David Layton. A partir de uma investigação qualitativa, foram levantados aspectos que deram subsídios para o entendimento do modo como tal disciplina surgiu e tomou espaço no currículo secundário nacional. O trabalho foi amparado numa metodologia de pesquisa bibliográfica que analisou livros, artigos, teses e dissertações. Além disso, o exame de documentos relativos as legislações educacionais auxiliaram a estruturação e escrita da história da disciplina de Física em nosso país. Todos os acontecimentos que possibilitaram o seu nascimento e desenvolvimento foram considerados a partir da teoria de David Layton. Este autor prevê que o movimento histórico de uma disciplina ocorre em três etapas, indo desde um princípio mais utilitarista e de interesse às resoluções de problemas imediatos de estudantes, passando por um processo de afirmação até o momento em que a disciplina, já estabilizada, aproxima-se das características das cadeiras universitárias. Os resultados da pesquisa mostraram que as contingências históricas da disciplina de Física no Brasil são muito particulares e não podem ser descritas em uma teoria geral.This text presents a research that analyzed the genesis and the evolution of the discipline of Physics in Brazil in the light of David Layton 's theory. From a qualitative investigation, aspects were raised that gave subsidies for the understanding of how this discipline emerged and took space in the national secondary curriculum. The work was supported by a methodology of bibliographic research that analyzed books, articles, theses and dissertations. In addition, the examination of documents related to educational legislation helped to structure and write the history of the discipline of Physics in our country. All the events that enabled his birth and development were considered from David Layton's theory. This author predicts that the historical movement of a discipline occurs in three stages, going from a more utilitarian and interest principle to the resolutions of immediate problems of students, passing through a process of affirmation until the discipline, already stabilized, approaches the characteristics of the chairs university students. The results of the research showed that the historical contingencies of the discipline of Physics in Brazil are very particular and cannot be described in a general theory

    Hieroglyphic Semantics in Late Antiquity

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    The primary aim of this thesis is the reconstruction of a development in the history of the philosophy of language, namely an understanding of hieroglyphic Egyptian as a language uniquely adapted to the purposes and concerns of late Platonist metaphysics. There are three main reasons for this particular focus. First, the primary interest of philological criticism has emphasized the apparent shortcomings of the classical hieroglyphic tradition in light of the success of the modern decipherment endeavour. Though the Greek authors recognize a number of philologically distinctive features, they are primarily interested in contrasting hieroglyphic and Greek semantics. The latter is capable of discursive elaboration of the sapiential content to which the former is non-discursively adapted. Second, the sole surviving, fully extant essay in the exegesis of Egyptian hieroglyphs, the Hieroglyphica of Horapollo can be situated within the broader philosophical project in which the Neoplatonic commentators were engaged. As such, it draws on elements of the distinct traditions of Greek reception of Egyptian wisdom, 4th/5th century pagan revivalism under Christian persecution, and late Platonist logico-metaphysical methodological principles. Third, the rationale for Neoplatonic use of allegorical interpretation as an exegetical tool is founded on the methodological principle of ‘analytic ascent’ from the phenomena depicted, through the concepts under which they fall, to their intelligible causes. These three stages in the ascent correspond to the three modes of expression of which, according to Greek exegetes, hieroglyphic Egyptian, as composites of material images and intelligible content, is capable. Horapollo’s Hieroglyphica, I argue, maintains a tripartite distinction between linguistic expressions, their meanings, and the objects or name-bearers which they depict and further aligns that distinction with three modes of hieroglyphic expression: representative, semantic, and symbolic. I conclude, therefore, that a procedure of analytic explanatory ascent from empirical observation through discursive reason to metaphysical or cosmological insights is employed in the exegesis of the sapiential content of the hieroglyphs of which it treats

    Attribution vs. possession in Coptic : The origin and development of an opposition

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    This paper is intended to reconstruct the process that led to the formal opposition between the patterns used for expressing possessive and attributive relationships in the Coptic language (Sahidic dialect). Having explained this opposition on a synchronic level, the following questions should be answered: What is the source of the formal likeness; How did this system develop, and what were the syntactic and semantic preconditions for such a grammaticalization? Having identified the common source, an additional question arises: How come the two constructions still differ, and do not show a complete formal identity

    Systematic review of clinical practice guidelines for acne vulgaris published between January 2017 and July 2021

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    Background: acne is very common, can cause considerable negative impact on quality of life and there is increasing concern over the use of long courses of oral antibiotics for this condition.Objectives: (1) To critically appraise reporting in acne guidelines and compare this with previous systematic review of acne guidelines. (2) Examine acne treatment guidance on pre-specified acne treatments of interest and compare between acne guidelines.Methods: searches for new or updated guidelines were carried out in MEDLINE, Embase, Google Scholar, LILACS from 1 January 2017 to 31 July 2021, supplemented by searching a guideline-specific depository and checking for updates to guidelines included in previous review. We included guidelines, consensus statements or care protocols on the medical treatment of acne vulgaris in adults and/or children and excluded those that focused on a single intervention or subgroup of acne, regional adaptations of guidelines or guidelines included in previous review. AGREE II checklist was applied to critically appraise reporting of guidelines. Results were synthesised narratively.Results: of 807 abstracts identified nine guidelines were identified that were eligible for inclusion. All guidelines had AGREE II scores above average in at least one domain and reporting was substantially improved compared to the systematic review of acne carried out 5 years previously. There was consensus between guidelines on the key role of topical treatments as first-line acne treatment and most recommended continuing topical treatments as maintenance therapy. There was considerable variation between guidelines on classification of severity, indications for commencing oral antibiotics and on maximum duration of oral antibiotics. However, there was consensus on the need for co-prescription of a non-antibiotic topical treatment when using oral antibiotics. There were notable differences on recommendations regarding provision of information for patients on how to use topical treatments or how to mitigate against side effects.Conclusions: substantial differences in classification of acne severity hampered comparisons between guidelines. Although development and reporting of guidelines has improved over the past 5 years, differences in key recommendations remain, possibly reflecting uncertainties in the underlying evidence base. Differences between guidelines could have substantial implications for prevalence of antibiotic prescribing for acne

    The rise and fall of the Labour league of youth

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    This thesis charts the rise and fall of the Labour Party’s first and most enduring youth organisation, the Labour League of Youth. The history of the League, from its birth in the early nineteen twenties to its demise in the late nineteen fifties, is placed in the context of the Labour Party’s subsequent fruitless attempts to establish and maintain a vibrant and functional youth organisation. A narrative is incorporated that illuminates the culture, organisation and political activism of the League and establishes it as a predominantly working class radical organisation. The reluctance on the part of the Labour Party to grant autonomy to its youth sections resulted in the history of the League of Youth being one of control, suppression and tension. This state of affairs ensured that subsequent youth groups, the Young Socialists and Young Labour, would be established in an atmosphere of reservation and scepticism. The thesis places the prime responsibility for the failure of the party’s youth organisations with the party leadership but also considers the contributory factors of changing social and political circumstances. A number of themes are explored which include the impact of structure and agency factors, the power of the Parliamentary Labour Party, the political socialisation of leading figures within the party, the social context in which each of the groups emerged and the extent to which the youth groups were prey to intra-party factionalism. The thesis redresses the balance of research where most accounts have focussed on the Young Socialists and traces the common characteristics that are prevalent in the way the party leadership has approached its relationship with its youth organisations. Use has been made of previously unpublished primary source material, the major source being the League of Youth members themselves whose recollections have helped to demonstrate the arguments put forward in this thesis

    Identifying acne treatment uncertainties via a James Lind Alliance Priority Setting Partnership

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    Objectives: The Acne Priority Setting Partnership (PSP) was set up to identify and rank treatment uncertainties by bringing together people with acne, and professionals providing care within and beyond the National Health Service (NHS). Setting: The UK with international participation. Participants: Teenagers and adults with acne, parents, partners, nurses, clinicians, pharmacists, private practitioners. Methods: Treatment uncertainties were collected via separate online harvesting surveys, embedded within the PSP website, for patients and professionals. A wide variety of approaches were used to promote the surveys to stakeholder groups with a particular emphasis on teenagers and young adults. Survey submissions were collated using keywords and verified as uncertainties by appraising existing evidence. The 30 most popular themes were ranked via weighted scores from an online vote. At a priority setting workshop, patients and professionals discussed the 18 highest-scoring questions from the vote, and reached consensus on the top 10. Results: In the harvesting survey, 2310 people, including 652 professionals and 1456 patients (58% aged 24 y or younger), made submissions containing at least one research question. After checking for relevance and rephrasing, a total of 6255 questions were collated into themes. Valid votes ranking the 30 most common themes were obtained from 2807 participants. The top 10 uncertainties prioritised at the workshop were largely focused on management strategies, optimum use of common prescription medications and the role of nondrug based interventions. More female than male patients took part in the harvesting surveys and vote. A wider range of uncertainties were provided by patients compared to professionals. Conclusions: Engaging teenagers and young adults in priority setting is achievable using a variety of promotional methods. The top 10 uncertainties reveal an extensive knowledge gap about widely used interventions and the relative merits of drug versus non-drug based treatments in acne management

    Demographic polarization and the rise of the far right: Brazil’s 2018 presidential election

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    Does the recent electoral success of far-right populists represent a mere rejection of the political and economic status quo, or has it revealed deeper cultural divides? Historically, demographic cleavages have been poor predictors of vote choice and partisanship in Latin America. However, during Brazil’s 2018 presidential election campaign, right-wing candidate Jair Bolsonaro fomented conflict across lines of gender, race, and religion. We argue that his candidacy activated latent, previously unexploited grievances in the electorate. Using survey data from an original five-wave online panel conducted between July 2018 and January 2019, we examine the effect of demographic cleavages on presidential vote choice. In stark contrast to prior elections, we find clear evidence of demographic divides in 2018, partially mediated by issue positions. Bolsonaro’s campaign and subsequent election thus appear to have created new identity-based alignments in Brazil’s electorate. Our findings shed further light on the global resurgence of the far right, suggesting that far-right candidates can attract new bases of support through demographic polarization, exploiting differences in values and issue preferences by gender, race, ethnicity, and religion.This article is published as Layton, M. L., Smith, A. E., Moseley, M. W., & Cohen, M. J. (2021). Demographic polarization and the rise of the far right: Brazil’s 2018 presidential election. Research & Politics, 8(1). https://doi.org/10.1177/2053168021990204. Posted with permission. © The Author(s) 2021. (CC BY-NC 4.0) This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage)
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