1,721,007 research outputs found

    the Movement Towards Personalized Medicine: Pharmacogenomics for Diagnosis and Treatment in Mood Disroders

    Get PDF
    The author explores holistic treatment approaches to bipolar disorder

    Going Beyond Counting First Authors in Author Co-citation Analysis

    Get PDF
    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Variations on the Author

    Get PDF
    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

    Get PDF
    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    Stopping Parkinson’s Disease with Phenylbutyrate: The Science, the History, and the Miles Left to FDA Approval

    Get PDF
    Of the most important things I\u27ve learned at Regis, science came second. Science, in its beautiful complexity, was straightforward. For a nine-year-old just learning English, science was a language that I understood just as well as the other English-speakers. I did not come from a background that prepped me for reading, writing, or American history, but none of that mattered when I was conducting fourth-grade science experiments. I welcomed the sense of community I felt when I was immersed in science, and for the next ten years of my life, I made science my home. Nevertheless, like science, we all must evolve. In my elementary understanding of it, I saw science as a dissection of the world, a systematic way to break down, analyze, and define my surroundings. If science was a brick, I wanted to take my microscope and probe every detail of it. I was ready to commit the rest of my life to that one brick—to study it, to test it, to carve my initials onto every surface of it. In my four years here at Regis, I spent a lot of time studying bricks, both metaphorical and physical. When I was building houses in Pinellas County on a Habitat for Humanity trip last spring, I spent an entire week adding bricks to the exterior walls of half-finished houses. The bricks came in different shades of beige, cream, and brown, and it was up to our job to cement the slabs together to create a sturdy, reinforced wall. Alone, the bricks were not that useful, but when cemented together, they represented the boundaries of a small office, an outline of a private bedroom, or a framework of a future 2 dining area. Eventually, I learned that science was not much different from those concrete bricks in Pinellas County. Science, I came to accept, was a building block that helped support a larger, more important design. As my understanding of science matured, I recognized its applications in economics, healthcare, politics, and public regulations. In turn, these factors feedback to affect the current scientific research process we know today. Science cannot and should not be isolated to a single brick, because its significance protrudes into boundaries well outside of the scientific community. It is no longer satisfactory to simply study science without regard to the context in which the science is applied, which is why, for this thesis, I will also be exploring the history and impacts of federal regulations on scientific research. Science, while already a compelling field on its own, is exponentially more influential and intriguing when studied in context of a larger picture. This project, at its core, is an exploration of science and detail. For many reasons, the questions I’m exploring in this research needs to be asked. How does this Parkinson’s disease-fighting drug work? What does the drug do? How does it fight Parkinson’s disease? But even more importantly, we have to ask what this science means in the larger scope. How soon can the drug be used? What are the long-term side effects? And in what ways can it help people? Mirroring the way my education developed in my four years at Regis, this thesis will first explore the science behind the phenylbutyrate mechanism. Then, it will take a step back and put the science into the context of historical and current drug research policies, FDA regulations on drug development, and previous Parkinson’s disease 3 research in hopes of identifying potential directions of the phenylbutyrate drug. Like the Pinellas County brick, science belongs to a greater infrastructure. The brick is not meant to be broken down and studied on its own; instead, it should serve as a building block. I have learned engage with science, to chisel it and recognize the ways it influences and builds the world. After years of narrowing my research in the laboratory, I’m left to ask myself in what ways I can expand—and that, is beyond textbook

    SURREALISM AND THE BRAIN: HOW ART UNVEILS THE MEANING OF MADNESS

    Get PDF
    Surrealist art has many connections to neurology and psychiatry, with its founder, Andre Breton, drawing great inspiration from his medical background and famous figures in both fields at the time. He sought to bring to light the functions of the brain by utilizing multiple techniques that were modified from those used for psychoanalysis on patients experiencing psychosis. While it is up for debate whether he was successful in creating a movement that accurately depicted the functioning of the unconscious mind, it is possible that through these techniques he was able to instead depict certain aspects of mentally ill minds. As such, I will argue that surrealist art did succeed in depicting brain functioning, although not in the way that the surrealists intended. Rather than accurately being able to describe the brain’s unconscious functionality, I believe that the madness present in surrealist artwork is indicative of the psychotic elements of brain function and is a display of how these functions can influence the way people see the world

    TCR_Compare

    No full text
    The TCR compare package has been developed as a sub module of the excellent ClusTCR platform developed by Valkiers et al. (2021), to enable like-for-like comparison across a series of clustering algorithms accessible from the command line

    Dispelling the Myths Behind First-author Citation Counts

    Get PDF
    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods
    corecore