22 research outputs found
Differential distribution of tropomyosin subunits in fast and slow rat muscles and its changes in long-term denervated hemidiaphragm
No full textDifferential distribution of tropomyosin subunits in fast and slow rat muscles and its change in long-term denervated hemidiaphragm.
Carraro U, Catani C, Dalla Libera L, Vascon M, Zanella G.
FEBS Lett. 1981 Jun 15;128(2):233-6. No abstract available.
PMID:
7262316
[PubMed - indexed for MEDLINE
A FAST TRIGGER PROCESSOR FOR LIMITED STREAMER TUBES
No full textAn electronic device has been realized which provides the total number of firing limited streamer tubes (LST) in different sectors as well as in the whole detector. These numbers are available a few microseconds after the read-out of the LST front-end electronics and can be used for trigger purposes
A CAMAC CONTROLLER FOR THE LIMITED STREAMER TUBE READOUT
No full textA controller is described for the limited streamer tube readout. It can handle up to 8192 channels organized in 8 buses at a rate of 5 MHz. The time required to collect and store all the data in memories is 205-mu-s. The data are then available to be read out via CAMAC in DMA mode by a computer
AN ANALOG MEAN TIMER FOR LONG SCINTILLATION COUNTERS
No full textAn analog mean-timer has been designed and tested with 3 m long scintillation counters. It provides the mean time of two ECL signals with better than 100 ps precision and can operate at up to 16 MHz
The time-of-flight TOFW detector of the HARP experiment: Construction and performance
No full textThe construction and performance of a large area scintillator-based time-of-flight detector for the HARP experiment at CERN are reported. An intrinsic counter time resolution of similar to 160 ps was achieved. The precision on the time calibration and monitoring of the detector was maintained at better than 100 ps by using dedicated cosmic rays runs, a fast laser-based system and calibrations with beam particles. The detector was operated on the T9 PS beamline during 2001 and 2002. A time-of-flight resolution of similar to 200 ps was obtained, providing pi/p discrimination at more than 3sigma up to 4.0 GeV/c momentum
A NEW EXPERIMENTAL LIMIT ON NEUTRON-ANTINEUTRON OSCILLATIONS
No full textThe experimental search for neutron-antineutron oscillations has been completed at the ILL high flux reactor at Grenoble. A neutron beam of intensity 10(11) n s-1 was propagated for a time t congruent-to 0.1 s in vacuum in a region shielded against the external magnetic field. No antineutron was detected in 2.4.10(7) s running time. The lower limit tau(nnBAR) greater-than-or-equal-to 0.86.10(8) s for nnBAR transitions was established at 90% C.L
Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance
No full textMitochondrial calcium (mtCa2+) uptake via the mitochondrial calcium uniporter (MCU) couples calcium homeostasis and energy metabolism. mtCa2+ uptake via MCU is rate-limiting for mitochondrial activation during muscle contraction, but its pathophysiological role and therapeutic application remain largely uncharacterized. By profiling human muscle biopsies, patient-derived myotubes, and preclinical models, we discovered a conserved downregulation of mitochondrial calcium uniporter regulator 1 (MCUR1) during skeletal muscle aging that associates with human sarcopenia and impairs mtCa2+ uptake and mitochondrial respiration. Through a screen of 5,000 bioactive molecules, we identify the natural polyphenol oleuropein as a specific MCU activator that stimulates mitochondrial respiration via mitochondrial calcium uptake 1 (MICU1) binding. Oleuropein activates mtCa2+ uptake and energy metabolism to enhance endurance and reduce fatigue in young and aged mice but not in muscle-specific MCU knockout (KO) mice. Our work demonstrates that impaired mtCa2+ uptake contributes to mitochondrial dysfunction during aging and establishes oleuropein as a novel food-derived molecule that specifically targets MCU to stimulate mitochondrial bioenergetics and muscle performance.</p
TRIGGER AND DATA ACQUISITION SYSTEM FOR THE N ANTI-N EXPERIMENT
No full textThe Trigger and Data Acquisition system of the N-NBAR experiment at the Institute Laue-Langevin at Grenoble is presented, together with CAMAC modules especially designed for this experiment. The trigger system is organized on three logical levels; it works in the presence of a high level of beam induced noise, without beam pulse synchronization, looking for a very rare signal. The data acquisition is based on a MicroVaxII computer, in a cluster with 4 VaxStations, interfaced to CAMAC and uses a modified version of the DAQP software developed at CERN. The system has been working for a year with high efficiency and reliability
A NEW EXPERIMENTAL LIMIT ON NEUTRON ANTINEUTRON TRANSITIONS
No full textAn experiment has been set up at the Institut Laue-Langevin in Grenoble to search for free neutron-antineutron oscillations. No candidate events were observed in the first run of the experiment, providing a lower limit in the oscillation time View the MathML source at 90% CL, which improves the previous experimental limit by an order of magnitude
