27,689 research outputs found
[Letter from Anthony P. Colombo to Anne Colombo - July 12, 1943]
No full textLetter from Anthony P. Colombo to Anne Colombo, his sister, discussing how he is doing and what they will do when he gets back. Their father would like to throw a party for Anthony
[Letter from Anthony P. Colombo to Annie Colombo - June 1, 1942]
No full textLetter from Anthony P. Colombo to Anne Colombo, his sister, discussing the money he saves and sends home, and asks Annie what size gloves she wears and talking about pictures he received
Phase Transitions in car Traffic & Pedestrian Flow Modeling
No full textEditori: R.M. Colombo, D. Kroener, P.G. Lefloc
Image Library: Acmopyle grayae A. Andruchow-Colombo, G. Rossetto-Harris, Tim J. Brodribb, M.A. Gandolfo, P. Wilf and Dacrycarpus engelhardti Wilf et Andruchow-Colombo
No full textFull-resolution image library of the two fossil Podocarpaceae species from Argentina- Acmopyle grayae A. Andruchow-Colombo, G. Rossetto-Harris, Tim J. Brodribb, M.A. Gandolfo, P. Wilf and Dacrycarpus engelhardti Wilf et Andruchow-Colombo - that were published here:Andruchow-Colombo, A., Rossetto-Harris, G., Brodribb, T. J., Gandolfo, M. A., and Wilf, P.. 2023. A new fossil Acmopyle with accessory transfusion tissue and potential reproductive buds: Direct evidence for ever-wet rainforests in Eocene Patagonia. American Journal of Botany e16221. https://doi.org/10.1002/ajb2.16221All photos taken by Peter Wilf.Please consult the provided Excel lookup table for the specimen data for both species and formal repository numbers.Please cite all material by repository number (not field number), prefixes MPEF-Pb, MAP-BAR, or USNM.Photo time stamp format is usually (YYYYMMDD HHMMSS).Please refer to the primary paper for all details and cite both the primary paper and this Figshare archive if you use these images.</p
Convergences and divergences of thymus-and peripherally derived regulatory T cells in cancer
No full textThe expansion of regulatory T cells (Treg) is a common event characterizing the vast majority ofhuman and experimental tumors and it is now well established that Treg represent a crucial hurdle fora successful immunotherapy. Treg are currently classified, according to their origin, into thymus-derived Treg (tTreg) or peripherally induced Treg (pTreg) cells. Controversy exists over the prevalent mechanism accounting for Treg expansion in tumors, since both tTreg proliferation and de novo pTreg differentiation may occur. Since tTreg and pTreg are believed as preferentially self-specific or broadly directed to non-self and tumor-specific antigens, respectively, the balance between tTreg and pTregaccumulation may impact on the repertoire of antigen specificities recognized by Treg in tumors. The prevalence of tTreg or pTreg may also affect the outcome of immunotherapies based on tumor-antigen vaccination or Treg depletion. The mechanisms dictating pTreg induction or tTreg expansion/stability are a matter of intense investigation and the most recent results depict a complex landscape. Indeed, selected Treg subsets may display peculiar characteristics in terms of stability, suppressive function, and cytokine production, depending on microenvironmental signals. These features may be differentially distributed between pTreg and tTreg and may significantly affect the possibility of manipulating Treg in cancer therapy. We propose here that innovative immunotherapeutic strategies may be directed at diverting unstable/uncommitted Treg, mostly enriched in the pTreg pool, into tumor-specific effectors, while preserving systemic immune tolerance ensured by self-specific tTreg. © 2013 Burocchi, Colombo and Piconese
Moderating Urbanization and Managing Growth: How Can Colombo Prevent the Emerging Chaos?
No full textThis paper examines urbanization trends, the growth of Colombo and its present state of development. It looks at the approaches to the planned interventions in the city and demonstrates how a uni-directional urban development has had a detrimental impactColombo, urban development, managing urbanization, planning, housing,
Regulatory T-cell inhibition versus depletion: the right choice in cancer immunotherapy
No full textTumour-induced expansion of regulatory T(T-Reg) cells is an obstacle to successful cancer immunotherapy. The potential benefit of T-Reg-cell depletion through the interleukin-2 receptor is lost by the concurrent elimination of activated effector lymphocytes and possibly by the de novo induction of T-Reg-cell replenishment. In theory, the functional inactivation of T-Reg cells will maintain them at high numbers in tumours and avoid their replenishment from the peripheral lymphocyte pool, which has the capacity to further suppress the effector lymphocyte anti-tumour response
La Rábida : Revista Colombina Iberoamericana. Número 156 - Año XV
No full text36 páginas.Marchena Colombo, José: 1492-1892-1927.- Recorno, Mario: Poesía. La carabela vuelve.- Programa de las fiestas patrióticas en los días del 1 al 4 de agosto.- Manuel Ugarte habla de Hispanoamericanismo.- Figura legendaria.- Marchena Colombo: D. Luis Rodríguez Caso (necrológica).- Marchena Colombo, José: La ciudad bella (San Sebastián).- Marchena Colombo: El Doctor Mackay (necrológica). Alexander o Alejandro Mackay, médico escocés, promotor del fútbol en Huelva.- Rodolfo Reyes (intelectual mexicano, visitará Huelva en las próximas fiestas colombinas)
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