573 research outputs found
The Δρομοδείχτης της Ελλάδος of 1824 and Athanasios Stageirites (Τίτλος περίληψης)
No full textσ. [281]-290Κείμενο στα ελληνικά με περίληψη στα αγγλικά με τον τίτλο: The Δρομοδείχτης της Ελλάδος of 1824 and Athanasios StageiritesThe article first examines the close relationship between the publication “Δρομοδείχτης της Ελλάδος” [1824] and the publication “Ηπειρωτικά” (1819) by Athanasios Stageirites and then suggests that Athanasios Stageirites is the likeliest author of the “Δρομοδείχτης της Ελλάδος”.Δωδώνη: Τεύχος Πρώτο: επιστημονική επετηρίδα του Τμήματος Ιστορίας και Αρχαιολογίας της Φιλοσοφικής Σχολής του Πανεπιστημίου Ιωαννίνων; Τόμ. 43-44 (2014-2015
Dataset in support of the Southampton doctoral thesis 'The boatbuilding tradition of the Aegean during the Late Neolithic – Early Bronze Age periods. Typological classification, digital reconstruction and seakeeping assessment'
No full textDataset in support of the Southampton doctoral thesis 'The boatbuilding tradition of the Aegean during the Late Neolithic – Early Bronze Age periods. Typological classification, digital reconstruction and seakeeping assessment' Appendix D - Resistance data and Appendix C - Stability data.
This dataset is focused on two appendices:
Appendix D - Resistance data. D.1 Resistance data produced by the author via MAXSURF Resistance for this thesis.
Appendix C - Stability data
C1. Stability data – STIX and ISO criteria, produced by the author via MAXSURF Stability software for his thesis
This research was funded by Southampton Marine and Maritime Institute (SMMI), Vice-Chancellor's Scholarship, Greek Archaeological Committee UK (GACUK)
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Peak power reduction algorithms in asymmetric digital subscriber line modems
No full textThesis (M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2000.Includes bibliographical references (leaves 94-96).This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.This thesis investigates peak-to-average ratio (PAR) reduction techniques for multicarrier modulation systems, such as discrete multitone (DMT) modems and orthogonal frequency-division multiplexed (OFDM) terrestrial broadcast transmitters. Through simulation and test implementation on a state-of-the-art programmable ADSL development platform, this thesis pursues a suitable solution for minimizing PAR given the resources of a programmable platform. This solution is integrated as a prototype implementation into a fully-functional ADSL modem and optimized for maximum PAR reduction performance within modem complexity constraints.by Athanasios Dimitri Dousis.M.Eng
Is laparoscopic surgery safe for the management of colon diseases?
No full textIntroduction of laparoscopic colectomy, initially as a hand-assisted procedure and finally performed completely laparoscopically, in the 1990s met with the serious concerns of surgeons of that period regarding the safe performance of these major procedures in a minimally invasive manner and, especially for colon cancer patients, the oncologic outcome. Impressively, due to the very frequent problem of port metastases (up to 21%!), laparoscopic colectomies were allowed to be performed only in clinical protocols. However, initial concerns were elucidated and outcomes were widely accepted. This was achieved due to well organized training courses of surgeons and the conclusion that, beyond the well known advantages of laparoscopic surgery, the surgical outcomes of patients treated for benign and more importantly malignant diseases were as good as them in open surgery. In this brief report, an analysis of this evolution historically and from the point of evidence-based surgery is carried out
Homophobic Statements, a Bishop, and the Limits of Freedom of Expression. An In-Depth Commentary on ECtHR 31.08.2023, Amvrosios-Athanasios Lenis v. Greece, no. 47833/20
No full textDichiarazioni omofobe, un vescovo e i limiti della libertà di espressione. Un commento approfondito su CEDU 31.08.2023, Amvrosios-Athanasios Lenis v. Greece, no. 47833/20.
ABSTRACT: The decision of the ECtHR of 31.08.2023, Amvrosios-Athanasios Lenis v. Greece (no. 47833/20), is a further step toward an increasingly dense jurisprudence on “hate speech” and the limits of freedom of expression. The public proclamation of religious doctrines that are in conflict with the values of the contracting States enshrined in the ECHR is protected to a certain extent by the fundamental right of freedom of religion and belief. However, the qualification of a statement as religious does not justify “hate speech.” The AUTHOR shows the tension between freedom of religion, freedom of expression, and protection against discrimination, and analyzes the decision against the backdrop of Article 17 of the ECHR (prohibition of abuse of rights).
SOMMARIO: 1. Preliminary Remarks - 2. The Concept of Hate Speech - 3. The Facts of the Case - 4. The Procedure and Reasoning of the Court - 4.1 The ECtHR’s Preliminary Considerations on Fundamental Rights - 4.2 Legal assessment - 4.3 Some Remarks on (the Non-Invoked) Article 9 of the ECHR - 5. Concluding Remarks
Changes of cytokines interleukin 1 (IL-1) and interleukin 6 (IL-6), TNFa and lactate in blood and CSF, as indicators of CNS ischemia due to intracranial hypertension during increased intra-abdominal pressure in pigs
No full textBackground: Clinical and experimental studies have reported the increase in intracranial pressure during intra-abdominal hypertension and abdominal compartment syndrome. However, no evidence exists regarding central nervous system (CNS) ischemia. In our experimental prospective study interleukin-6 (IL-6), tumor necrosis factor-a (TNFa) and lactate (Lac) were measured as indicators of CNS ischemia. Materials and methods: Eleven pigs were studied. After placement of catheters for pressure monitoring and sample collection helium pneumoperitoneum via an infraumbilically inserted Veress needle was established to mimic intra-abdominal hypertension. A gradual increase of intra-abdominal pressure (IAP) to 20mmHg for 1h and furthermore to 45 mmHg for another hour was finally followed by abdominal dessuflation. Blood and cerebrospinal fluid (CSF) samples were collected. Non parametric tests were used. Results: Increased IAP resulted in increased intracranial pressure (ICP), increased intraspinal (ISP) pressure and concomitant decreased cerebral and spinal perfusion pressures (CPP and SPP). Interestingly, a pronounced increase of IL-6 in blood (635 pg/ml to 755 pg/ml, p=0,043) and CSF (611,5 pg/ml to 917,5 pg/ml, p=0,028) and a similar response of elevated CSF lactate (1,53 mmol/L to 2,42 mmol/L, p=0,017) were not followed by statistically significant increases of blood lactate and TNFa. Spearman analysis revealed a significant correlation between ISP changes and increases in CSF IL-6 (p=0,042). Conclusions: Intra-abdominal hypertension is followed by CNS hypertension and concomitant hypoperfusion possibly leading to CNS ischemia as is hypothesized by increases in TNFa, IL-6 and lactate CSF concentrations demonstrated in this experimental study in pigs.Εισαγωγή: Κλινικές και πειραματικές μελέτες έχουν αναφερθεί μέχρι σήμερα στην αύξηση της ενδοκράνιας πίεσης ως αποτέλεσμα της ενδοκοιλιακής υπέρτασης και του συνδρόμου κοιλιακού διαμερίσματος. Ωστόσο, δεν υπάρχουν δεδομένα που αφορούν στην ισχαιμία του κεντρικού νευρικού συστήματος (ΚΝΣ). Στη προοπτική πειραματική αυτή μελέτη η ιντερλευκίνη-6 (IL-6), ο παράγοντας νέκρωσης του όγκου (TNFa) και το γαλακτικό οξύ (Lac) μετρήθηκαν ως δείκτες της ισχαιμίας του ΚΝΣ. Υλικά και Μέθοδοι: Ένδεκα χοίροι μελετήθηκαν. Μετά τη τοποθέτηση των καθετήρων για τη παρακολούθηση των πιέσεων και τη συλλογή των δειγμάτων, εγκαταστάθηκε πνευμοπεριτόναιο με ήλιο με εισαγωγή βελόνας Veress υπομφαλίως δημιουργώντας συνθήκες ενδοκοιλιακής υπέρτασης. Η προοδευτική αύξηση της ενδοκοιλιακής πίεσης (ΕΚΠ) από τις φυσιολογικές τιμές στα 20mmHg για 1 ώρα και η περαιτέρω αύξησή της στα 45 mmHg για άλλη μια ώρα ακολουθήθηκε τελικά από αποσυμπίεση της κοιλίας. Δείγματα αίματος κι εγκεφαλονωτιαίου υγρού (ΕΝΥ) συλλέχτηκαν σε όλες τις φάσεις. Μη παραμετρικές δοκιμασίες χρησιμοποιήθηκαν για τη στατιστική ανάλυση. Αποτελέσματα: Η αύξηση της ΕΚΠ είχε ως αποτέλεσμα την αύξηση της ενδοκράνιας και ενδονωτιαίας πίεσης με παράλληλη ελάττωση της πίεσης αιμάτωσης του εγκεφάλου και του νωτιαίου μυελού (CPP and SPP, αντίστοιχα). Έχει ενδιαφέρον η στατιστικά σημαντική αύξηση της IL-6 στο αίμα (635 pg/ml to 755 pg/ml, p=0,043) και το ΕΝΥ (611,5 pg/ml to 917,5 pg/ml, p=0,028) και η παρόμοια αύξηση του γαλακτικού στο ΕΝΥ (1,53 mmol/L to 2,42 mmol/L, p=0,017), οι οποίες όμως δεν συνοδεύθηκαν από αντίστοιχες μεταβολές (στατιστικά σημαντικές) του γαλακτικού στο αίμα και του TNFa. Η ανάλυση συσχέτισης Spearman αποκάλυψε μια στατιστικά σημαντική συσχέτιση μεταξύ του ρυθμού μεταβολής της πίεσης του ΕΝΥ στο νωτιαίο σωλήνα και την αύξηση της IL-6 του ΕΝΥ (p=0,042). Συμπεράσματα: Η υπέρταση του ΚΝΣ και η ελάττωση των πιέσεων αιμάτωσής του (CPP and SPP) που παρατηρήθηκαν με την αύξηση της ΕΚΠ οδηγούν σε ισχαιμία, η οποία αφορά τόσο τον εγκέφαλο, όσο και τον νωτιαίο μυελό. Η αύξηση της IL-6 και του γαλακτικού οξέος στο ΕΝΥ μπορούν να θεωρηθούν ως ευαίσθητοι δείκτες της ισχαιμίας του ΚΝΣ
Η έκφραση του συνδέτη του μορίου προγραμματισμένου κυτταρικού θανάτου PD-L1 (programmed cell death ligand-1) στον κολο-ορθικό καρκίνο
No full textΕισαγωγή: Η εισαγωγή νέων φαρμάκων που στοχεύουν στο ανοσοποιητικό σύστημα φαίνεται να αλλάζει το τοπίο στην αντιμετώπιση του καρκίνου. Πέντε ανοσολογικά σημεία ελέγχου έχουν εντοπιστεί ως πιθανοί στόχοι της ανοσοθεραπείας: το μόριο του προγραμματισμένου κυτταρικού θανάτου PD-1 (programmed cell death), ο συνδέτης του PD-L1 (PD ligand), η πρωτεΐνη 4 σχετιζόμενη με τα κυτταροτοξικά Τ-λεμφοκύτταρα CTLA4 (cytotoxic T-lymphocyte associated protein 4), το γονίδιο ενεργοποίησης των λεμφοκυττάρων LAG-3 (lymphocyte activation gene) και η διοξυγενάση της ινδολαμίνης IDO (indoleamine 2,3-dioxygenase). Στόχος: Να μελετηθεί η έκφραση του μορίου PD-L1 σε παθολογοανατομικά δείγματα από γαστρικό και κολο-ορθικό καρκίνο. Μέθοδος: Η έκφραση του μορίου PD-L1 μετρήθηκε με ειδική ανοσοϊστοχημική μέθοδο και βαθμονομήθηκε σε ένα σύστημα τριών επιπέδων: α) έκφραση < 1% (απουσία έκφρασης), β) έκφραση 1-49% (χαμηλή έκφραση) και γ) έκφραση > 50% (υψηλή έκφραση). Όλα τα δείγματα γαστρικού καρκίνου ήταν αρνητικά για έκφραση του μορίου PD-L1, οπότε και δεν συμπεριλαμβάνονται στη μελέτη. Αποτελέσματα: Μελετήθηκαν 32 δείγματα ασθενών με κολο-ορθικό καρκίνο, 16 άνδρες και 16 γυναίκες, με μέση ηλικία 71,4 έτη (45-93). Ιστολογικά, τα περισσότερα νεοπλάσματα ήταν μέτριας διαφοροποίησης (24) και λιγότερα χαμηλής διαφοροποίησης (8). Η έκφραση του μορίου PD-L1 ήταν απούσα σε 21 ασθενείς (65,6%), χαμηλή σε 5 (15,6%) και υψηλή σε 6 ασθενείς (18,75%). Σε όλους τους ασθενείς με υψηλή έκφραση του PD-L1 ανευρέθηκε υψηλή μικροδορυφορική αστάθεια (MSI-high). Συμπεράσματα: Η έκφραση του μορίου PD-L1 ανευρίσκεται συνήθως αυξημένη στην υπο-ομάδα των ασθενών με κολο-ορθικό καρκίνο που έχει μικροδορυφορική αστάθεια.Introduction: The development of new therapeutic agents aiming at pathways of the immune system seem to change the treatment of several cancers. Five immune check-points have been found as possible targets of immunotherapy: the programmed cell death molecule PD-1, its ligand PD-L1, cytotoxic T-lymphocyte associated protein 4 (CTLA4), the lymphocyte activation gene (LAG-3) and indoleamine 2,3-dioxygenase (IDO). Aim: To study the expression of PD-L1 in histological specimens of gastric and colorectal cancers. Methods: The expression of PD-L1 was measured with a standardized immunohistochemical method and was categorized in three levels: a) expression < 1% (absence of expression), b) expression 1-49% (low expression), and c) expression > 50% (high expression). All specimens of gastric cancers were negative for expression of PD-L1 and were not included finally in this study. Results: Thirty-two (32) specimens of patients with colorectal cancer were studied, 16 males and 16 females, with a medium age of 71,4 years (45-93). Histologically, most cancers were moderately differentiated (24) and the remaining (8) were poorly differentiated. Expression of PD-L1 was absent in 21 patients (65,6%), low in 5 (15,6%) and high in 6 patients (18,75%). All patients with a high expression of PD-L1 expressed high microsatellite instability (MSI-high). Conclusion: High expression of PD-L1 is usually associated with high microsatellite instability in patients with colorectal cancer
La tomba III di Haghios Athanasios e il valore semantico dell'incarnato
No full textThe tomb III at Haghios Athanasios stands out among the Macedonian tombs for the exceptional painted decoration of the temple-like façade. Excavated in the '90s by M. Tsimbidou-Avloniti it has been published by the scholar in full detail and the iconographic program of the monument has been the object of many publications. This article re-examines the different ways of reproducing the skin color (το ανδρείκελον) in the figures of the miniature frieze and in the megalographic figures beside the door. The realistic rendering of the megalographic figures of armed men in Macedonian attire, showing their sorrow for the lost of an etairos, is contrasting with the pale color of the participants to the symposion in the frieze above the door, a scene whose illusionistic overtone has been yet perceived by the critics. This symposion is articulated in three scenes and it can be interpeted as a necrodeipnon, but in the same time as a celebration of the Macedonian banquet style, centered on the royal court. The author suggests that the first figure on the right of the frieze, related to the group of armed men looking towards the banqueters feasting in the center of the frieze, can be read as the dead himself, for the particular rendering of his ανδρείκελον, showing the typical ochròtes or necròdes face color, according to the contemporary medical lexicon. The pathetic stance assumed by the same figure, the sole in the group which is not bearing arms, seems to confirm his role in the context of the scene
Computational Modelling of Compaction in Asphaltic Mixtures and Geomaterials
No full textAsphaltic mixtures are heterogeneous composite materials consisting of aggregates coated and bound by asphalt binder. The long term performance of asphaltic pavements is highly dependent on the mechanical behaviour of the asphaltic mixture during construction (mixing and compaction) and operation; inadequate mixture compaction leads to faster moisture and oxygen diffusion, ravelling, rutting and poor fatigue life
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