262,205 research outputs found
Context-based risk-adaptive security model and conflict management
No full textIn dynamic and risk-prone environments, security rules should be flexible enough to permit the treatment of risks, and to manage privileges on resources based on the situation at hand. For this purpose, we define safety-centric contexts based on risk description that is provided by the safety management system. This paper presents a riskadaptive access control model that adopts hierarchies of contexts and security domains to make adaptations to risks at different levels of criticality. Since various risks may arise simultaneously, two or more security domains might be applicable at the same time incorporating various security rules which might lead to conflicts. Therefore, an approach to analyze conflicts is essential. In this work, we propose a conflict analysis algorithm based on set theory and we illustrate its usage with the proposed risk-adaptive access control model
MC1R gene: comparison between different farm animal species
No full textIl gene MC1R: confronto fra diverse specie animali di interesse zootecnico. Negli animali di interesse zootecnico, il polimorfismo del gene MC1R coinvolto nella pigmentazione è stato studiato a livello molecolare soltanto nell’ultimo decennio. Si sono confrontate descrizioni fenotipiche e polimorfismi del gene MC1R in alcune razze bovine (Rendena, Bruna, Cabannina, Ottonese-Varzese e Pezzata Rossa) e nel cavallo (62 animali). Tutti gli animali feomelanici sono portatori delle mutazioni recessive allo stato omozigote indipendentemente dalla tonalità del mantello. I cavalli neri sono portatori dell’allele selvatico del gene MC1R e della mutazione recessiva del gene ASIP allo stato omozigote. Nei cavalli bai e nelle altre razze bovine studiate è presente, almeno allo stato eterozigote, l’allele selvatico. Nella Bruna e nella Cabannina è presente anche l’allele E1. Nel gene MC1R, sequenziato in capre di razza Bionda dell’Adamello e Nera di Verzasca, si è evidenziata l’unica mutazione descritta in letteratura. I risultati sono stati confrontati con le informazioni disponibili nella specie murina e umana.Coat colour genes in farm animals have only been studied at molecular level over the last ten years, starting with Klungland et al. in 1995. Among the genes involved in pigmentation, MC1R, previously known as Extension locus, revealed polymorphisms related to red and black coat colour in different farm animal species. More exactly, the MelanoCortin-1 Receptor (MC1R) gene, specifically expressed in melanocytes, encodes for the homonymous G-protein coupled receptor involved in the regulation of the type of melanin synthesized. Melanocytes produce in fact two different types of melanins: the black or brown eumelanin and the yellow or red pheomelanin. The hair distribution of eu- and pheomelanins depends on the activity of MC1R, which is normally modulated by response to the melanocortin hormone, antagonized by the action of Agouti protein encoded by the ASIP gene. We previously studied the MC1R polymorphisms in some cattle reared in Italy (Crepaldi et al., 2003) and we now present the data on MC1R in other Italian cattle breeds, horses and goats. The aim of this work is to compare the pigmentary phenotypes and causative MC1R mutations in different farm animals and model species, such as mouse and human, in order to highlight differences and similarities between phenotypes and MC1R polymorphisms. The relationship between phenotypes and Agouti locus is also discussed
P16INK4a as a progression/regression tumour marker in LSIL cervix lesions: Our clinical experience
No full textPurpose of investigation: The aim of this prospective study was the evaluation of low-grade intraepithelial lesion (LSIL) lesions evolvement in woman with evidence of high risk HPV infection and p16 INK4a negative expression. Materials and Methods: 150 women with cytological diagnosis of LSIL were selected to be underwent to three years of follow-up consisting in smear test, colposcopy, and protein p16 INK4a investigation every six months and HPV-test every 12 months. Result: Final follow-up showed 45 cases of spontaneous lesion regression and 42 cases of persistence with absence of protein p16 INK4a in all of them. There were three cases of disease progression to CIN2, two at 18-month follow-up and one at last follow-up. Disease progression was characterized of p16 INK4a expression. Conclusion: p16 INK4a should help to identify which LSIL cases are inclined to the progression of the disease and focalize which patients are eligible for specific treatment
Diagnosis, antenatal surveillance and management of prolonged pregnancy: Current perspectives
No full textProlonged pregnancy is defined as a pregnancy that extends beyond 42 weeks of gestation (294 days) from the first day of the last normal menstrual period. An accurate estimation of the ‘natural’ incidence of prolonged pregnancy would require meticulous early pregnancy dating. The use of ultrasound to establish gestational age reduces the number of pregnancies that are classified as prolonged. Prolonged pregnancy is associated with an increased perinatal mortality and morbidity in pregnancies which appear to be otherwise low risk. Postterm births are easily preventable by intervening to deliver with the use of induction of labor. Thus, this potentially problematic condition deserves further attention and careful consideration. The focus of this article is to review and challenge some current concepts surrounding the diagnosis and management of prolonged pregnancy. We outline how to identify those women with prolonged pregnancy and which is the appropriate moment to start monitoring the fetal wellbeing. Finally we address the question of benefits and hazards of induction of labor strategies
Intrafollicular nerve growth factor concentration in patients with polycystic ovary syndrome: A case-control study
No full textBACKGROUND: To evaluate the concentration of nerve growth factor (NGF) in follicular fluid of women affected by polycystic ovary syndrome (PCOS) undergoing to In Vitro Fertilization cycle. Methods: In the context of an in-vivo study, a sample of 52 women was considered: 20 were without pathology (male infertility - control group) and 32 were affected by PCOS. All patients received a long stimulation protocol and the oocytes obtained by pick-up were fertilized with standard procedures of intracytoplasmic sperm injection (ICSI). Samples of follicular fluid (FF) were collected at oocyte pick-up. After centrifugation at 560 × g for 3 min, follicular fluid samples were frozen at-80 °C. After thawing the values of NGF in FF were determined by enzyme immunoassay ELISA using commercially available NGF enzyme-linked immunosorbent assay kits. The results of study were analyzed statistically with Student's t-Test. Results: The content of NGF was higher in FF of PCOS patients (2023.30±587.09 pg/mL) in comparison with control group (1704.09±326.8 pg/mL; P<0.05). The levels of serum estrogen (E2) were higher in patients with PCOS (1724.24±635.79 pg/mL) than in control group (1305.3±298.12 pg/mL; P<0.05). The number of retrieved oocytes was more in PCOS patients (9.7±4.6) than in control group (8±4.4), but oocytes in metaphase II were similar in two groups (6.2±2.4 vs. 6.09±4). ConclusionS: The present results show that ovaries of PCOS patients produce more NGF than non-PCOS patients; it confirms that an excess of ovarian NGF might be an abnormality contributing to polycistic ovary morphology and PCOS
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Protecting Animals 36: Author Witi Ihimaera
No full textIn this very special episode of Knowing Animals I am joined by beloved New Zealand author Witi Ihimaera. Witi has written many books featuring nonhuman animals. He offers us a non-colonial lens through which to think about the human/nonhuman relationship
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Differential rotation and activity cycles in RS Canum Venaticorum binaries. I - RU CNC and CQ AUR
No full textA number of seasonal light curves of the RS CVn variables RU Cnc and CQ
Aur, obtained from 1977 - 1978 to 1982 - 1983 at Catania and Torino
Observatories, are studied by applying recently developed techniques of
time series analysis for nonequally sampled data. The results of this
study appear to support the hypothesis that dark spots are responsible
for the photometric variations. A simple method, based on a solar
analogy, allows to determine both the differential rotation and the
latitude drift of the spotted regions. The latitude drift is accompanied
by variations of the light curve amplitude suggesting the existence of
spot activity cycles with a period of about 4 years in both binary
systems
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