79 research outputs found
The genomic profile of pregnancy-associated breast Cancer: a systematic review
No full textBreast cancer is the most common malignancy diagnosed during pregnancy. Strong data on the genomic profile of pregnancy-associated breast cancer are lacking. This systematic review aims to integrate and analyze all existing data from the literature regarding the genomic background and the gene mutational patterns of pregnancy-associated breast cancer. Using various genomic analysis methods, multiple differentially expressed genes and numerous non-silent mutations have been detected. More particularly, our review demonstrates the aberrant expression of several oncogenes (e.g., MYC, SRC, FOS), tumor suppressor genes (e.g., TP53, PTEN, CAV1), apoptosis regulators (e.g., PDCD4, BCL2, BIRC5), transcription regulators (e.g., JUN, KLF1, SP110), genes involved in DNA repair mechanisms (e.g., Sig20, BRCA1, BRCA2, FEN1), in cell proliferation (e.g., AURKA, MKI67), in the immune response (e.g., PD1, PDL1), and in other significant biological processes (e.g., protein modification, internal cell motility). Further research on the genomic profile of pregnancy-associated breast cancer is urgently required in order to identify potential biomarkers facilitating early-stage diagnosis and individualized therapy. © Copyright © 2020 Korakiti, Moutafi, Zografos, Dimopoulos and Zagouri
A modernidade e os encontros turísticos: turistas na Barra de Lagoa
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas. Programa de Pós-Graduação em Ciências Humanas.Esta pesquisa tem como tema a modernidade e o turismo. O turismo pode ser compreendido como um fenômeno constituinte da modernidade, a partir das particularidades da experiência moderna. Atualmente, tem sido uma das atividades econômicas que mais cresce no mundo. Entretanto, independentemente dos aspectos econômicos relacionados ao turismo, há outras dimensões do fenômeno turístico que têm sido investigadas no campo das Ciências Humanas, onde se encontram diferentes áreas de conhecimento em suas distintas formas de percepção do fenômeno turístico. Ao mesmo tempo, a categoria de análise turismo tem sido problematizada pelos estudiosos, e o tema tem suscitado abordagens mais interdisciplinares. Nesse contexto, parte-se do entendimento do significado do turismo como fenômeno a ser compreendido a partir da condição moderna e de seus reflexos em nossas sociedades contemporâneas. Busca-se, nesse sentido, resgatar certas dimensões da modernidade, assim como as formas pelas quais o turismo tem sido tratado no debate acadêmico, visando contribuir para este debate nas Ciências Humanas, em especial, nas Ciências Sociais. Entretanto a própria problematização da categoria turismo passa pela necessidade de investigações empíricas. Nesse sentido, o turismo pode ser entendido como uma forma de experiência concretizada pelas práticas turísticas. Assim, a figura do "turista" é um elemento central da constituição do fenômeno turístico e representa elementos da experiência moderna contemporânea, associados à subjetividade. Para tratar dessas questões teóricas e empíricas, pesquisou-se uma das formas pelas quais tem-se constituído a experiência turística, que é a visitação a balneários, que apresenta uma história particular associada à modernidade e ao turismo. No caso do Brasil, o turismo nas praias é uma das principais manifestações das práticas turísticas, contexto em que cidades como Florianópolis-SC têm sido cenário de crescente fluxo de turistas e também objeto de investigação acadêmica, assim como institucional. Como espaço turístico em Florianópolis, foi escolhida a praia da Barra da Lagoa. Busca-se, assim, também contribuir nos estudos sobre turismo em Florianópolis, a partir das particularidades da Barra da Lagoa como local turístico. Para tal, adotamos a concepção de "encontros turísticos", enquanto um conjunto de elementos diversos associados aos sentimentos e envolvendo a relação com pessoas, lugares, natureza e self. Como resultado, pode-se pensar o turismo como práticas que se constituem de pequenos encontros com os sentimentos e com o self. Os "encontros turísticos" incluem os encontros do turista consigo mesmo, ou com o self. Florianópolis e a Barra da Lagoa são locais onde se manifestam essas experiências subjetivas e que têm abarcado diversos tipos de "encontros turísticos".The subject of this research is modernity and tourism. Tourism can be understood as a phenomenon that constitutes modernity considering particularities of modern experience. Currently it is one of the fastest growing economic activities. However, regardless of economic aspects related to tourism, there are other dimensions of the tourist phenomenon that have been investigated in the field of Human Sciences, presenting different areas of knowledge in their distinct forms of perception of the tourist phenomenon. At the same time, scholars have problematized "tourism" as an analysis category, and the subject has aroused rather interdisciplinary approaches. In this context, we start from the awareness of the meaning of tourism as a phenomenon to be understood from the modern condition, and of its reflexes in our contemporary societies. In this sense, we try to recover certain dimensions of modernity, as well as the forms through which tourism has been dealt with in the academic debate, aiming at contributing to this debate in Human Sciences, but especially in the Social Sciences. Yet problematizing the category "tourism" itself involves the need for empiric investigation. In this sense, tourism can be understood as a form of experience concretized by tourist practices. So the figure of the "tourist" is a central element in the constitution of the tourist phenomenon, and represents elements of the contemporary modern experience associated to subjectivity. In order to deal with such theoretical and empirical matters, we have investigated one of the forms that have constituted the tourist experience, which is visiting beach resorts, presenting a particular history associated with modernity and tourism. In the case of Brazil, beach tourism is one the main manifestations of tourist practices, a context in which cities such as Florianópolis (SC - Brazil) has been the scenario of a growing flow of tourists, and also the object of both academic and institutional investigation. The beach resort Barra da Lagoa, Florianópolis, was chosen as the tourist space. The aim of this choice is to contribute to studies on tourism in Florianópolis starting from the particularities of the Barra da Lagoa as a tourist place. For such we have adopted the conception of "tourist encounters" as a set of diverse elements associated to feelings and involving the relationship with people, places, nature and the self. As a result we can think of tourism as practices consisting of small encounters with feelings and with the self. "Tourist encounters" include the encounter of the tourist with himself/herself or with the self. Florianópolis and Barra da Lagoa are places where such subjective experiences take place, and which have encompassed several kinds of "tourist encounters"
Tracing the missing fragments of Cycladic architecture: a geo-ethnoarchaeological study on the degradable architectural elements of the Cyclades
No full textCycladic architecture has been the focus of archaeological, ethnographic and architectural studies, which have produced significant knowledge about the islands’ built environment. Despite the number of published studies, there is little archaeological evidence related to the parts of buildings, such as roofs and second storeys made of degradable materials (i.e. sediments and organic materials), which are nowadays lost or poorly preserved. On the other hand, ethnographic and architectural studies lack the details of local variabilities regarding the construction of the fragile architectural components. This geo-ethnoarchaeological study applied a high-resolution analysis including soil micromorphology and phytoliths to the roofs of abandoned traditional farmsteads (mitata) on two islands, Kato Kouphonisi and Naxos in the Cyclades, supplemented by oral testimonies from elderly residents and published ethnographic information. This was combined with comparable microstratigraphic analysis conducted on sediments from the nearby Early Bronze Age site of Dhaskalio, Keros. The analysis of abandoned farmsteads generated a high-resolution dataset of micro-characteristics linked to known practices and materials of traditional roof construction. These were then traced into our archaeological samples to detect similar features and ultimately improve on contextual interpretation beyond field observations. We therefore suggest that this geo-ethnoarchaeological approach is useful in the identification of roof sediments in archaeological deposits, enhancing the ability to recognise such events in the field and demonstrating that a signature of collapse events can be defined. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature
The prognostic role of biomarkers in kidney injury in children and adolescents with type 1 diabetes mellitus: a systematic review and meta-analysis
No full textThis study aims to conduct a systematic review investigating the prognostic role of KIM-1, NGAL, L-FABP and cystatin C in kidney injury in children and adolescents with type 1 diabetes mellitus
Exploring connectivity in Late Bronze Age/Early Iron Age Greece and the Balkans using cranial non-metric analysis
No full textThe present study aims to explore connectivity and networking in Late Bronze Age (LBA)/Early Iron Age (EIA) Greece and the Balkans using morphological biodistance analysis and test the potentiality of newly introduced statistical tests, which were designed for challenging datasets, in this particular cultural area. Cranial non-metric traits were recorded in ten skeletal collections, spanning from East Crete to Romania. We followed an experimental statistical approach encompassing two different measures of divergence, the conventional and well-tested mean measure of divergence (MMD) and the newly introduced untransformed measure of divergence (UMD). Though different, results based on these two measures are mutually supporting and show that biodistances in our regional case studies mainly follow the isolation by distance model. This cautiously confirms our main hypothesis that during the LBA and EIA periods in Greece and the Balkans, personal mobility was a slow process characterized by integration, rather than displacement or transformation. The current study is the first one to infer biological affinities using cranial non-metric analysis combined with artifactual evidence, in LBA/EIA Greece and the Balkans. Building a larger dataset through future non-metric analyses will better enable exploring networking and mobility to further complement ongoing bioarchaeological, genetic, and material culture studies
Efficacy of an Oral Rehydration Solution Enriched with Lactobacillus reuteri DSM 17938 and Zinc in the Management of Acute Diarrhoea in Infants: A Randomized, Double-Blind, Placebo-Controlled Trial
No full textThe efficacy of oral rehydration solution (ORS) enriched with Lactobacillus reuteri DSM 17938 and zinc in infants with acute gastroenteritis, is poorly defined. The aim of this double-blind, randomized, placebo-controlled study, was to assess the efficacy of an ORS enriched with Lactobacillus reuteri DSM 17938 and zinc (ORS+Lr&Z) in well-nourished, non-hospitalized infants with acute diarrhoea. Fifty one infants with acute diarrhoea were randomly assigned to receive either ORS+Lr&Z (28 infants, mean ± SD age 1.7 ± 0.7 years, 21 males), or standard ORS (ORS−Lr&Z; 23 infants, mean ± SD age 1.8 ± 0.7 years, 16 males). Stools volume and consistency were recorded pre- and posttreatment using the Amsterdam Infant Stool Scale and were compared between the two groups, as well as lost work/day care days, drug administration and need for hospitalization. Both groups showed reduction in the severity of diarrhoea on day two (p < 0.001) while, all outcomes showed a trend to be better in the ORS+Lr&Z group, without reaching statistical significance, probably due to the relatively small number of patients. No adverse effects were recorded. In conclusion, both ORS were effective in managing acute diarrhoea in well-nourished, non-hospitalized infants. ORS enriched with L. reuteri DSM 17938 and zinc was well tolerated with no adverse effects
The Efficacy of Corticosteroids in pediatric kidney scarring prevention after pyelonephritis: A Systematic Review and Meta-analysis of Randomized Clinical Trials
No full textOur aim is to systematically review the current literature and conduct a meta-analysis investigating the effect of adjuvant corticosteroid administration to antibiotic therapy in pediatric patients with APN
263.4 kb deletion within the TCF4 gene consistent with Pitt–Hopkins syndrome, inherited from a mosaic parent with normal phenotype
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