170 research outputs found
We are mock'd with art: theatricalizing devices in performances of Shakespeare's The Winter's Tale
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Letras/Inglês e Literatura Correspondente, Florianópolis, 2011This dissertation discusses the use of theatricalizing devices in four stage productions of William Shakespeare's The Winter's Tale. The selected performances were staged by the Royal Shakespeare Company (England, 1992), Théâtre de la Complicité (England, 1992), Folger Theatre (United States, 2009), and Companhia Atores de Laura (Brazil, 2004-2005). The discussion is structured following the notion of "performance text", proposed by Marco de Marinis (1993), which testifies to the importance of analyzing a performance in terms of its stage elements and also its contextual circumstances. Hence, the notion of "theatricalizing devices" is proposed in the present study as a tool to look at those devices employed on stage that can, simultaneously, comment on the theatrical medium and its conventions and help a production address themes and concerns related to the world outside the theater building. Additionally, the referred devices have to do with further fictionalizing the already fictional stage reality, without losing sight of the fact that those making and attending any given performance are inserted in an outside context.A presente tese discute o uso de recursos teatricalizantes em quatro produções teatrais de O Conto do Inverno, de William Shakespeare. As performances selecionadas foram produzidas pela Royal Shakespeare Company (Inglaterra, 1992), Théâtre de la Complicité (Inglaterra, 1992), Folger Theatre (Estados Unidos, 2009), e Companhia Atores de Laura (Brasil, 2004-2005). A discussão está estruturada seguindo a noção de "texto espetacular" proposta por Marco de Marinis (1993), a qual testemunha a favor da importância de se analisar uma performance em termos de seus elementos de palco e também de suas circunstâncias contextuais. Dessa forma, a noção de "recursos teatricalizantes" é proposta na presente tese como ferramenta para olhar aqueles recursos empregados no palco que podem, simultaneamente, comentar o meio teatral e suas convenções e ajudar uma produção a tratar temas e preocupações relacionados ao mundo existente para além do auditório do teatro. Além disso, os referidos recursos associam-se com ficcionalizar mais profundamente a realidade já fictícia do palco teatral, sem perder de vista o fato que os indivíduos que realizam e assistem a qualquer performance estão inseridos em um contexto exterior
Clinical utility of gadobenate dimeglumine in contrast-enhanced MRI of the breast: a review
No full textBreast magnetic resonance imaging (MRI) is considered the technique with the highest sensitivity for breast cancer detection. Gadobenate dimeglumine is a gadolinium-based contrast agent (GBCA) that is specifically approved in Europe for breast MRI and which has the highest r1 relaxivity among all GBCAs for this indication. In order to improve the diagnostic performance of breast MRI, several intra-individual crossover studies have evaluated gadobenate dimeglumine as a possible GBCA for this application. This review focuses on the role and advantages of gadobenate dimeglumine as a contrast agent for breast MRI by describing the unique properties of this agent and by summarizing published studies
Stadiazione preoperatoria del carcinoma mammario mediante RM
No full textStaging is an important step in the evaluation of patient management. Xray mammography and breast ultrasound can have some limitations in several cases. In these cases breast MRI is useful as it is the technique with the highest value of sensitivity. Main indications to preoperative breast MRI are dense breast, the lobular invasive cancer and high risk patients. Moreover it is helpful also for the evaluation of contralateral breast cancer, the involvement of the nipple-areola complex or of the chest wall
Errors in imaging of emergencies in pregnancy
No full textThere is evidence that emergencies in pregnancy are subject to mismanagement; however, the percentage of error in the diagnosis of emergencies in pregnancies has not been studied in-depth. The purpose of this article is to review the most common emergencies in pregnancies, focusing the attention on errors in images. The topics covered are divided into gynecological and nongynecological, and for each pathology, the possible errors in the diagnostic pathway, the possible technical errors in the execution of the examination, and in the end, the possible errors in interpretation of the images have been dealt with. These last two entities are often connected, in the fact that a substandard examination can stem interpretation errors, but the systemization of the error is a valid approach in helping to learn from these errors, reducing the possibility that the same error can represent itself. © 2012 Elsevier Inc.
Aspectos biofarmacéuticos y tecnológicos que impactan en la absorción y la biodisponibilidad de los medicamentos
No full textPara facilitar su administración, aceptación y dosificación los fármacos son convenientemente combinados con excipientes convenientes para ser formulados como medicamentos en diversas formas farmacéuticas. Las formas farmacéuticas en que puede ser elaborado un medicamento pueden variar desde simples soluciones a complejos sistemas de liberación, utilizando excipientes apropiados o dispositivos para su administración. La administración de un medicamento a un ser vivo desencadena en el organismo una serie de eventos conocidos como acción medicamentosa o procesos LADME (liberación, absorción, distribución, metabolismo y excreción). Tal como se muestra en la figura 1, la acción medicamentosa puede ser también dividida en 3 fases, la fase farmacéutica, la fase farmacocinética y la fase farmacodinámica. Para que el proceso de absorción tenga lugar, el fármaco contenido en la forma farmacéutica debe liberarse y disolverse en los fluidos que lo rodean. Este proceso está limitado por la solubilidad del fármaco en las condiciones que ofrece el sitio de administración. Todos los eventos que tienen lugar previo a la absorción, corresponden a la fase farmacéutica de la acción medicamentosa y, en consecuencia, la magnitud y la velocidad de absorción del medicamento (es decir su biodisponibilidad) van a depender de la magnitud y la velocidad con la que el fármaco se libere de la forma farmacéutica que lo contiene y de la capacidad de ese fármaco para atravesar las membranas (es decir, su permeabilidad). Una vez que la absorción tiene lugar, el fármaco es distribuido en el organismo a través de la circulación sistémica. Paralelamente, se ponen en marcha los procesos de eliminación (metabolismo y excreción). Esta etapa se conoce como fase farmacocinética. Finalmente, el fármaco que accede a los órganos diana podrá interactuar con los receptores celulares dando lugar a una respuesta biológica conocida como la fase farmacodinámica. Una vez absorbido, el fármaco debe llegar al sitio de acción (también conocido como sitio diana o biofase) para interactuar con los receptores celulares o sistemas enzimáticos y así producir los efectos terapéuticos buscados. La cantidad de fármaco que accede a la biofase y el tiempo que tarda en llegar y en desaparecer de allí, condicionan la intensidad y la duración de la respuesta farmacológica. A su vez, la cantidad que llega dependerá de la dosis administrada, de la magnitud en que se absorbe, de cómo se distribuye y la velocidad y magnitud con la que el organismo lo excreta. En consecuencia, la magnitud e intensidad de la respuesta a la administración de un medicamento depende de una serie de características propias del fármaco, de la formulación que lo contiene, de la vía de administración y de las características del paciente, incluyendo su edad y la patología. Dichas características serán desarrolladas a lo largo de este capítulo.Fil: Olivera, Maria Eugenia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Guzman, Maria Laura. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Luciani Giacobbe, Laura Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentin
Effect of Preoperative Breast Magnetic Resonance Imaging on Surgical Decision Making and Cancer Recurrence Rates
No full textPurpose: To evaluate breast magnetic resonance imaging (MRI) for cancer staging and surgical planning in patients with known breast cancer, and to evaluate recurrence rates at long-term follow-up. Methods and Materials: Institutional review board approval and patient consent were obtained. Preoperative MRI with 0.1 mmol/kg gadobenate dimeglumine (MultiHance) was performed in 203/274 women with confirmed breast cancer. The sensitivity, accuracy, and positive predictive value of MRI compared with mammography/ultrasound for malignant lesion detection were calculated, and the effect of MRI on surgical decision making evaluated. The cancer recurrence rate was determined for 172 patients with available 2- to 8-year follow-up data. Results: Mammography/ultrasound detected 229 suspicious lesions. Breast MRI detected 159 additional lesions in 48/203 (23.6%) patients; of which 110/110 were correctly classified as malignant and 28/49 as benign, giving sensitivity, accuracy, and positive predictive values for malignant lesion detection of 100% (110/110), 86.8% (138/159), and 84.0% (110/131), respectively. MRI revealed unsuspected multifocal, multicentric, and synchronous contralateral lesions in 7/48, 16/48, and 16/48 patients, respectively, and pectoralis muscle infiltration in 3/38 patients. In 6/48 women, MRI revealed lesions not seen on conventional imaging (n = 5) or discounted suspected multifocal disease (n = 1). Therapy was changed for 50/203 (24.6%) patients: 38 patients underwent more extensive surgery and 12 less extensive surgery. Six (3.5%) recurrences occurred, in all cases at >4 years. Conclusion: Breast MRI positively affects patient management and is recommended for mapping tumor extent in patients with newly diagnosed cancer. The cancer recurrence rate at long-term follow-up after MRI is low
Urinary excretion of mannose and mannose related compounds in humans consuming Aloe saponaria pulp
No full textThe adhesion of Escherichia coli to uroepithelium can be altered by the interaction between specific carbohydrate molecules and the receptors on the bacterial surface. Mannose is one of the most potent inhibitors among carbohydrates. Aloe saponaria, currently used as a dietary supplement, contains polymannanes as main components. This work was designed to evaluate the mannose oligosaccharide metabolites excretion after oral intake of Aloe saponaria pulp in order to estimate its potential utility in preventing urinary infections. Five volunteers received a daily oral intake of Aloe saponaria pulp for 7 days. Urine samples were collected at time 0 and on the seventh day and assayed for their mannose contents by Dubois method, TLC, HPLC and 1H-NMR. The results showed that the oral intake of Aloe Saponaria fresh pulp produced sugar excretion, composed mainly of mannose and mannose related compounds, suggesting that Aloe saponaria pulp could be a potential therapeutic agent for prevention of urinary tract infection.Fil: Fallati, Claudia Silvina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; ArgentinaFil: Olivera, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Luciani Giacobbe, Laura Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Romañuk, Carolina Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Manzo, Ruben Hilario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentin
Changes in total choline concentration in the breast of healthy fertile young women in relation to menstrual cycle or use of oral contraceptives: a 3-T 1H-MRS study
No full textBACKGROUND:
To evaluate changes in total choline (tCho) absolute concentration ([tCho]) in the breast of healthy fertile women in relation to menstrual cycle (MC) or use of oral contraceptives (OC).
METHODS:
After institutional review board approval, we prospectively evaluated 40 healthy fertile volunteers: 20 with physiological MC, aged 28 ± 3 years (mean ± standard deviation; nOC group); 20 using OC, aged 26 ± 3 years (OC group). Hormonal assays and water-suppressed single-voxel 3-T proton magnetic resonance spectroscopy (1H-MRS) were performed on MC days 7, 14, and 21 in the nOC group and only on MC day 14 in the OC group. [tCho] was measured versus an external phantom. Mann-Whitney U test and Spearman coefficient were used; data are given as median and interquartile interval.
RESULTS:
All spectra had good quality. In the nOC group, [tCho] (mM) did not change significantly during MC: 0.8 (0.3-2.4) on day 7, 0.9 (0.4-1.2) on day 14, and 0.4 (0.2-0.8) on day 21 (p = 0.963). In the OC group, [tCho] was 0.7 (0.2-1.7) mM. The between-groups difference was not significant on all days (p ≥ 0.411). All hormones except prolactin changed during MC (p ≤ 0.024). In the OC group, [tCho] showed a borderline correlation with estradiol (r = 0.458, p = 0.056), but no correlation with other hormones (p ≥ 0.128). In the nOC group, [tCho] negatively correlated with prolactin (r = -0.587, p = 0.006) on day 7; positive correlation was found with estradiol on day 14 (r = 0.679, p = 0.001).
CONCLUSIONS:
A tCho peak can be detected in the normal mammary gland using 3-T 1H-MRS. The [tCho] in healthy volunteers was 0.4-0.9 mM, constant over the MC and independent of OC use
Primary Extranodal Follicular T-Cell Lymphoma and Ductal Breast Carcinoma Diagnosed by a Magnetic Resonance Imaging-Guided Vacuum-Assisted Biopsy: A Case Report
No full textHéros fondateurs et identités communautaires dans l’Antiquité entre mythe, rite et politique
No full textInternational audienceLe volume réunit les actes du colloque international «Héros fondateurs et identités communautaires dans l’Antiquité, entre mythe, rite et politique» qui s’est tenu à Grenoble du 3 au 5 mai 2017. La question des origines et du sentiment d’appartenance des communautés anciennes, des mythes et des cultes consacrés aux ancêtres légendaires dont elles revendiquaient la descendance a été abordée en privilégiant, à travers la variété géographique et chronologique des exemples étudiés, une approche pluridisciplinaire finalisée à enrichir la réflexion historiographique.Contributions de Ezio Pellizer, Giuseppina Paola Viscardi, Karin Mackowiak, Francesca Giovagnorio, Stefano Acerbo, Anna Bertelli, Federica Cordano, Marina Polito, Simonetta Angiolillo, Alfredo Novello, Maria Elena Gorrini, Cesare Zizza, Alessandro Cocorullo, Raffaella Bonaudo, Eliana Mugione, Victor Sánchez Domínguez, Paolo Daniele Scirpo, Marco Giuman, Ciro Parodo, Hélène Bernier-Farella, Marek Titien Olszewski, Houmam Saad, Romina Carboni, Emiliano Cruccas, Maria Cristina Biella, Laura Maria Michetti, Enrico Giovanelli, Massimiliano Di Fazio, Marco Edoardo Minoja, Luisa Ferrero, Stefania Padovan, Francesca Restano, Serena Mola, Domenico Palombi, Eva Hagen, Nicola Luciani, Jean-Luc Lambole
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