23 research outputs found
Urban air mobility. From sectoral infrastructure to an integrated vision towards improved inclusion
No full textIl contributo propone una riflessione su possibili strategie di riequilibrio insediativo di area vasta. Le proposte formulate muovono dall'ipotesi di implementare sistemi di Advanced Air Mobility nelle aree meno densamente abitate. Il contributo esplora l'immagine della AAM nell'immaginario collettivo. Sintetizza le caratteristiche dell'implementazione della AAM nel Piano nazionale per gli aeroporti. Esplora i margini di fattibilità di una implementazione pervasiva della AAM come strumento idoneo ad abbattere i tempi di spostamento delle aree meno infrastrutturate. Propone uno schema di rete di AAM che potrebbe contribuire alla costruzione di una regione urbana integrata abbattendo le barriere all'accessibilità alle aree interne
Advanced Air Mobility. A New Type of Mobility in Remote Areas for the Creation of Sustainable Landscapes
No full textIl contributo propone una riflessione su possibili strategie di riequilibrio insediativo di area vasta. Le proposte formulate muovono dall'ipotesi di implementare sistemi di Advanced Air Mobility nelle aree meno densamente abitate. Il contributo esplora l'immagine della AAM nell'immaginario collettivo. Sintetizza le caratteristiche dell'implementazione della AAM nel Piano nazionale per gli aeroporti. Esplora i margini di fattibilità di una implementazione pervasiva della AAM come strumento idoneo ad abbattere i tempi di spostamento delle aree meno infrastrutturate. Propone uno schema di rete di AAM che potrebbe contribuire alla costruzione di una regione urbana integrata abbattendo le barriere all'accessibilità alle aree interne.The contribution presents a reflection on possible strategies for settlement rebalancing in a vast area. The proposals put forth start from the assumption of implementing Advanced Air Mobility systems in less densely populated areas. The contribution explores the image of AAM in the collective imagination. It summarizes the characteristics of AAM implementation in the National Airport Plan. It explores the feasibility of a pervasive implementation of AAM as a suitable tool to reduce travel times in less infrastructure-rich areas. It suggests a network schema of AAM that could contribute to the construction of an integrated urban region by breaking down barriers to access to interior areas
Prospettive di ripresa per il paesaggio delle aree interne. Nuove infrastrutture per la regione urbana. Il Piano Commissariale per l'itinerario infrastrutturale della Salaria
No full textL'articolo presenta un'esperienza applicata che si profila come una buona pratica di costruzione di processi decisionali in grado di aggregare e integrare diverse azioni entro orizzonti strategici formulati su base territoriale. L'occasione nasce dalla decisione del Governo di sviluppare, attraverso l’intervento commissariale, un Piano unitario e complessivo di adeguamento dell’intero itinerario tra Roma e Ascoli Piceno. Il Commissario, nell'ambito del suo mandato, ha stabilito di articolare la propria azione organizzandola su due livelli: a) una dimensione strategica e b) una dimensione operativa con la definizione di 54 interventi. Come cornice di riferimento del Piano è stato sviluppato uno studio multidisciplinare.
Il contributo proposto restituisce sinteticamente l'orizzonte scientifico, il metodo, il campo di indagine, gli strumenti e dati, e l'organizzazione dello studio. Il contributo si completa attraverso una sintesi dello stato di attuazione del piano e dei relativi ulteriori esiti attesi.The article reports on an applied experience that emerges as a good practice in the construction of decision-making processes capable of aggregating and integrating different actions within strategic horizons formulated on a territorial basis. The opportunity arises from the Government's decision to develop, through the commissioner's intervention, a unitary and comprehensive plan for adapting the entire itinerary between Rome and Ascoli Piceno. The Commissioner, within his mandate, decided to articulate his action by organizing it on two levels: a) a strategic dimension and b) an operational dimension with the definition of 54 interventions. A multidisciplinary study was developed as a framework for the plan.
The article summarizes the scientific horizon, the method, the field of investigation, the tools and data, and the organization of the study. The contribution is completed through the report on the state of implementation of the plan and the related further expected outcomes
Gli spazi pubblici aperti per la rigenerazione urbana nella prospettiva postpandemica. Indicazioni di metodo. La "best practice" del "Parco Europa Unita" in Potenza
No full textThe Sars-CoV-2 pandemic has imposed on each of us a long and difficult experience. In this crisis, both elements of criticality and change emerged: elements which had already been underway for some time. The imposition of smart working (in both public and private context) and the physical displacement restrictions (which restrained accessibility to central areas) have promptly led to the demand relocation for public services (nearby green spaces) and private commercial services.
The critical issues of a settlement model that has always remained predominantly centripetal have become evident. The instances of widespread urban quality, of better quality of life, of ecosystemic rebalancing of the settlement system have become, for few moment, pressing and shared.
In short time, even if not promptly followed by market trends, the level of urban rent value (in its pricing effects in shop and home rents) appeared to be widely excessive.
In metropolitan areas, it was made clear that through a diversified planning of timetable and through the diversification of flows, it would be easy to restore existing mobility infrastructures, with only management measures, to excellent service levels.
In this new perspective it is interesting, after fifteen years, to deepen the methods and the tools of the experience of urban regeneration, reported by many (Ispra; National Council of Architects) as "best practice", of "Europa Unita" park in Potenza.
This project allows to deepen the design strategies implemented to enhance the "role of the ecological-environmental component within urban systems". This is accomplished through a "systemic approach" and with an "holistic vision" rooted in the evolutionary trends of territorial realities.
The fifteen years passed since the Park inauguration allows us to go back to the method and project choises with the aims to find confirmations and any critical issues. This can be done by verifying the project at different scales as well as by studying the choices of planning tools that have governed this successful process of urban transformation
Il paesaggio delle aree interne verso La regione urbana. La direttrice di transumanza della Via Salaria
No full textIl contributo propone una riflessione su possibili strategie di riequilibrio insediativo di area vasta che, muovendo dalla consapevolezza che le specificità identitarie dei luoghi e gli assetti vegetazionali trovano le loro origini nel sistema produttivo della transumanza. Le ipotesi tendono a esplorare la possibilità di costruire una regione urbana integrata abbattendo, attraverso nuove e tradizionali infrastrutture per la mobilità, le barriere all'accessibilità alle aree interne.The contribution proposes a reflection on possible settlement rebalancing strategies of a large area which, starting from the awareness that the identity specificities of the places and the vegetation arrangements find their origins in the productive system of transhumance. The hypotheses tend to explore the possibility of building an integrated urban region by breaking down, through new and traditional infrastructures for mobility, the barriers to accessibility to inland areas
The selective inhibition of inducible nitric oxide synthase prevents intestinal ischemia-reperfusion injury in mice
No full textNitric oxide (NO) involvement in intestinal ischemia–reperfusion (I/R) injury has been widely
suggested but its protective or detrimental role remains still question of debate. Here, we examine
the impact of supplementation or inhibition of NO availability on intestinal dysmotility and
infammation caused by mesenteric I/R in mice. Ischemia 45min and reperfusion 24 h were
performed by superior mesenteric artery occlusion in female Swiss mice. Saline-treated shamoperated
(S) or normal mice without surgery (N) served as controls. Drugs were subcutaneously
injected 0, 4, 8, and 18 h after ischemia. Upper gastrointestinal transit (GIT, estimated through
black marker gavage), intestinal myeloperoxidase activity (MPO), intestinal malondialdehyde levels
(MDA), Evans blue extravasation (EB), intestinal histological damage, and mean arterial pressure
(MAP) were considered. In I/R mice, GIT was significantly delayed compared to S and N groups;
MPO activity and EB extravasation enhanced, whereas MDA levels did not change. Compared to N
and S groups, in I/R mice selective iNOS inhibitor P-BIT significantly prevented motor, MPO and
EB changes; putative iNOS inhibitor aminoguanidine significantly counteracted GIT delay but not
neutrophil recruitment and the increase in vascular permeability; NOS inhibitor L-NAME and NO
precursor L-arginine were scarcely or no effective. Furthermore, in S mice aminoguanidine caused
a significant increase of MPO activity reverted by H1 histamine receptor antagonist pre-treatment.
Unlike P-BIT, aminoguanidine and L-NAME injection increased MAP. These fndings confirm a
detrimental role for iNOS-derived NO overproduction during reperfusion. Aminoguanidine
associated neutrophil recruitment suggests that this drug could act through mechanisms additional
to iNOS inhibition involving both eNOS blockade, as indicated by its hemodynamic effects, and
indirect activation of H1 histamine receptors. Nitric Oxide 14 (2006) 212–21
The River Contract of the Tiber from Castel Giubileo to the Foce: An Innovative Practice for a Relationship between Tiber and Rome
No full textThe River Contract is a little-known practice and an unconventional planning procedure but an opportunity in many Italian Regions to overcome the problems of coherence between levels of Government and to promote participation. The River Contract is a voluntary agreement of strategic and negotiated planning, aiming the protection, proper management of water resources, recovery, and enhancement of the river territories, together with flood protection, contributing to the local development of such areas. In 2017, in Rome, started the procedure for the River Contract by Agenda Tevere Onlus. This paper illustrates a practice-oriented research built by multidisciplinary approach and a method able to mix cultural and participatory knowledge. Because the Tiber is the river of Rome, the research aims to raise the possibility of enhancing the strategic and fundamental role of the Tiber in relation to the City through four key issues: the urban landscape, because the Tiber is intrinsically related with the city; the public space, because the Tiber must be a good of the city; the sustainable use, because the Tiber must be for the city; the active participation, because the interventions on the Tiber must be shared in the city by those who live and work in Rome
Evidence for the involvement of 5-HT(2A) receptors in mild mesenteric ischemia/reperfusion dysfunctions in mice
No full text
Vertebral morphometry by X-ray absorptiometry: Which reference data for vertebral heights?
No full textIntroduction: The recent improvement in the resolution of dual-energy X-ray absorptiometry (DXA) images enables most vertebral levels to be seen adequately and thus DXA may be a worthwhile alternative to radiologic morphometry for the identification of vertebral fractures (VF). In this multicenter study, we have derived reference data for vertebral heights and their ratios in Italian women using morphometric X-ray absorptiometry (MXA). Methods: DXA scans were acquired in 1254 consecutive pre- and postmenopausal women, (mean age 63.7 +/- 11.3, range 26-88 yrs), referred to six osteoporosis centers. MXA analysis of these images was performed by the same operator measuring vertebral heights and height ratios from L4 to T4. We calculated measures of central tendency and dispersion of vertebral heights and vertebral ratios using different approaches (mean and standard deviation as well as median and interquartile range of raw data, mean and standard deviation of trimmed data using an iterative algorithm, and mean and standard deviation of not fractured vertebrae). Results: Independently of the approach that we used, all the measures of central tendency were similar, while significant differences were found when compared with reference ranges in other populations. The vertebral heights of our sample at every vertebral level were significantly smaller than both Rea population and the Lunar reference values, even after normalization. Splitting data according to age groups, there was a decrease in the vertebral heights and ratios between the younger and older women. Conclusions: This study demonstrates that reference data for MXA should be population specific and age matched. (C) 2011 Elsevier Inc. All rights reserved
