1,721,246 research outputs found
Molecular mechanisms behind inherited neurodegeneration of the optic nerve
Full text linkInherited neurodegeneration of the optic nerve is a paradigm in neurology, as many forms of isolated or syndromic optic atrophy are encountered in clinical practice. The retinal ganglion cells originate the axons that form the optic nerve. They are particularly vulnerable to mitochondrial dysfunction, as they present a peculiar cellular architecture, with axons that are not myelinated for a long intra-retinal segment, thus, very energy dependent. The genetic landscape of causative mutations and genes greatly enlarged in the last decade, pointing to common pathways. These mostly imply mitochondrial dysfunction, which leads to a similar outcome in terms of neurodegeneration. We here critically review these pathways, which include (1) complex I-related oxidative phosphor-ylation (OXPHOS) dysfunction, (2) mitochondrial dynamics, and (3) endoplasmic reticulum-mito-chondrial inter-organellar crosstalk. These major pathogenic mechanisms are in turn interconnected and represent the target for therapeutic strategies. Thus, their deep understanding is the basis to set and test new effective therapies, an urgent unmet need for these patients. New tools are now available to capture all interlinked mechanistic intricacies for the pathogenesis of optic nerve neuro-degeneration, casting hope for innovative therapies to be rapidly transferred into the clinic and effectively cure inherited optic neuropathies
Le forme di autotutela del datore di lavoro e la repressione della condotta antisindacale
No full textIl rapporto di lavoro nell'appalto
No full textIl contributo analizza le regole applicabili ai rapporti di lavoro nel caso in cui il lavoratore venga impiegato dal datore di lavoro per la realizzazione dell'opera o del servizio dedotti ad oggetto del contratto di appalt
Indagine in allevamenti bufalini della provincia di Caserta sulla produzione e sulla qualità del latte
No full textUniversità degli Studi di Napoli “Federico II
Indagine in allevamenti bufalini della provincia di Caserta sulla produzione e sulla qualità del latte
No full textUniversità degli Studi di Napoli “Federico II
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