1,930 research outputs found
Other works of Serigne Mor Kayre
No full textThe entire manuscript is available for download below as a single PDF file. Because of the large size of this manuscript, it is also available in two PDF files. In addition, each page is available as a separate, larger, JPG file. If higher-resolution JP2 files are needed (WARNING: files average 11-14MB in size), please contact [email protected].
Fieldwork Team: Dr. Fallou Ngom (PI), Cheikh Tidiane Fall (Co-applicant), Ablaye Diakite (Researcher), Birane Gassama (Researcher).
Technical Team: Roger Brisson (Head of Metadata Services, BU Libraries), Vika Zafrin (Institutional Repository Librarian, BU Libraries), Jack Ammerman (Associate University Librarian for Digital Initiatives and Open Access, BU Libraries), and Dr. Peter Quella.
This collection of Wolofal (Wolof Ajami) materials is copied as part of the EAP 334 Project (Digital Preservation of Wolof Ajami manuscripts of Senegal) led by Dr. Fallou Ngom in collaboration with WARA/WARC and Boston University Library. The project is funded by the British Library/Arcadia Endangered Archives.
Access Condition and Copyright: The materials are subject to copyright. Access is for research and educational purposes only. Materials are not to be reproduced without written permission.
Citation: Materials in this web edition may be cited as: Ngom, Fallou. 2011. African Ajami Library: EAP 334. Digital Preservation of Wolof Ajami Manuscripts of Senegal. Boston: Boston University Library: http://dcommon.bu.edu
For Inquires: Please, contact Professor Fallou Ngom ([email protected])The material consists of Wolof Ajami poems (Wolofal) by Serigne Mor Kayre (1869-1951). The material is written in black ink. There are also insertions of Arabic words and phrases, including in openings and closings. The collection contains discussions on the qualities of Prophet Muhammad, the qualities of a genuine Murid disciple, discussions on the Tijaniyya and Qadiriyya Sufi orders, as well as recommendations for Murid disciples and their leaders.
Serigne Mor Kayre (1869-1951) was one of the earliest Murid Ajami scholars and poets. He was a member of the Tijaniyya Sufi order before becoming a Murid disciple when he met Ahmadou Bamba. His work includes eulogies of some Murid leaders, praises of Prophet Muhammad and Ahmadou Bamba's teachings, and devotional Sufi poetry, among others. His work has helped to disseminate Bamba's teachings and the Murid work ethics among the Wolof masses. His poetry has generated some Sufi songs, some of which are available on the internet today.
Serigne Mor Kayre is the author and scribe of the 2 original pages, but the copyist of the 74 photocopied pages of the work is unknown.
Mame Mor Kayre, the owner of the materials, is named after his grandfather Serigne Mor Kayre (1869-1951), the author the materials. He was born in 1978 in Khombole in the region of Thies. Mame Mor Kayre is currently a quranic teacher in Touba-Darou Khoudoss, Senegal. He received the materials from his older half-brother called Khadim Kayre, a quranic teacher and writer living in Dakar, Senegal.
Digitized on 27 November 2011.
The 74 handwritten pages copied are readable, but the 2 original pages are difficult to read due to their age.British Library (EAP 334
Some of the works of Serigne Mor Kayre
No full textDate created: unknown. The entire manuscript is available for download below as a single PDF file. Each page is also available as a separate, larger, JPG file. If higher-resolution JP2 files are needed (WARNING: files average 11-14MB in size), please contact [email protected].
Fieldwork Team: Dr. Fallou Ngom (PI), Cheikh Tidiane Fall (Co-applicant), Ablaye Diakite (Researcher), Birane Gassama (Researcher)
Technical Team: Roger Brisson (Head of Metadata Services, BU Libraries), Vika Zafrin (Institutional Repository Librarian, BU Libraries), Jack Ammerman (Associate University Librarian for Digital Initiatives and Open Access, BU Libraries), and Dr. Peter Quella.
This collection of Wolofal (Wolof Ajami) materials is copied as part of the EAP 334 Project (Digital Preservation of Wolof Ajami manuscripts of Senegal) led by Dr. Fallou Ngom in collaboration with WARA/WARC and Boston University Library. The project is funded by the British Library/Arcadia Endangered Archives.
Access Condition and Copyright: The materials are subject to copyright. Access is for research and educational purposes only. Materials are not to be reproduced without written permission.
Citation: Materials in this web edition may be cited as: Ngom, Fallou. 2011. African Ajami Library: EAP 334. Digital Preservation of Wolof Ajami Manuscripts of Senegal. Boston: Boston University Library: http://open.bu.edu
For Inquires: Please, contact Professor Fallou Ngom ([email protected])These materials are a collection of Wolof Ajami (Wolofal) poems by Serigne Mor Kayre (1869-1951). Red and black ink are used in the first set of original manuscripts. The red ink is used to highlight key words and phrases. There are also insertions of Arabic words and phrases, including in opening and closing formulae. The collection contains a hagiography of Prophet Muhammad, his family members and his miracles; a discussion on the battle of Badr; a song dedicated to Cheikh Ahmadou Bamba; a discussion on the norms for the construction of a mosque; a tribute to Serigne Modou Moustapha Mbacke (the first khalifa of the Muridiyya order); a tribute to Serigne Moussa Ka (his fellow Murid disciple and poet); and a table of contents summarizing the author's key pieces of work, among others.
Materials consist of 17 pages of the original manuscript and 53 photocopies of some of Serigne Mor Kayre's work copied by hand. Serigne Mor Kayre is the author and scribe of the 17 original pages, but the copyist of the 53 photocopied pages of his work is unknown.
Digitized on 24 July 2011.
Due to the age and poor quality of the photocopy of some pages, some lines are a hard to read. Many of Mor Kayre's original works are lost.This collection of Wolofal (Wolof Ajami) materials is copied as part of the EAP 334 Project (Digital Preservation of Wolof Ajami manuscripts of Senegal) led by Dr. Fallou Ngom in collaboration with WARA/WARC and Boston University Library. The project is funded by the British Library/Arcadia Endangered Archives
Letter from Ois�n Ua Mor�in to Fr. O'Callaghan
No full textHolograph letter from Ois�n Ua Mor�in of The New Leader, 205 New Brunswick Street, Dublin, to Fr. O'Callaghan [Rome]. The author of the article is happy if his name is disclosed to Dr. O'Hagan and will be glad to be in communication with him; he is Fr. E. Carroll in Crayford, Kent
Monoglyceride lipase: Structure and inhibitors
No full textMonoglyceride lipase (MGL), the main enzyme responsible for the hydrolytic deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG), is an intracellular serine hydrolase that plays critical roles in many physiological and pathological processes, such as pain, inflammation, neuroprotection and cancer. The crystal structures of MGL that are currently available provide valuable information about how this enzyme might function and interact with site-directed small-molecule inhibitors. On the other hand, its conformational equilibria and the contribution of regulatory cysteine residues present within the substrate-binding pocket or on protein surface remain open issues. Several classes of MGL inhibitors have been developed, from early reversible ones, such as URB602 and pristimerin, to carbamoylating agents that react with the catalytic serine, such as JZL184 and more recent O-hexafluoroisopropyl carbamates. Other inhibitors that modulate MGL activity by interacting with conserved regulatory cysteines act through mechanisms that deserve to be more thoroughly investigated
Interactions between atypical opioid agonists and MOR
No full textEndomorphins (EMs) are endogenous peptides with high selectivity for MOR; they induce strong antinociception by binding to both central and peripheral MOR but, unlike morphine, they are effective in reducing neuropathic pain and their analgesic effect seems to be dissociated by immunomodulatory, cardiovascular and respiratory effects. As native EMs show poor bioavailability and rapid degradation in vivo, we designed and assayed novel EM-1 (YPWF-NH2) derivatives bearing chemical modification aimed to improve their application as analgesics. The ionic bond between a protonated amine and a conserved Asp in the third TMH of the opioid receptor is considered the driving force for ligand-receptor interaction of all opioid agonists, being the amine of Tyr the key pharmacophore for opioid peptides. The removal or derivatization of this pharmacophore usually transforms agonists into inactive compounds or antagonists, with only few compounds maintaining an agonist behaviour when deprived of such amino group. Recently, we discovered the novel EM-1 derivative c[YpwFG]; it displayed good affinity to MOR (Ki 34 nM), is an effective and potent analgesic for visceral pain when administered peripherally (i.p ED50 1,25 mg/kg; s.c. ED50 2,7 mg/kg), and retains central analgesic effects (tail-flick test) only at high doses (20 mg/kg). Interestingly, it triggers MOR internalization similarly to DAMGO but displayed an opposite effect on MOR transcription. This cyclopeptide is a structurally atypical opioid agonist, being deprived of the key pharmacophore, therefore we performed investigations by 2D-NMR, conformational analysis, and molecular docking to provide insights into its interaction with and activation of MOR. The resulting receptor-bound structure served as a general model to design new MOR-active compounds containing the sequence wF, to optimize ligand-receptor interactions. This search lead to c[YGwFG], which showed a 10- fold higher affinity for the MOR (Ki 3,6 nM) as well as good analgesic properties in vivo. Finally, we verified the predictive power of the general model by designing a non-EM-like opioid compound, the cyclic tetrapeptide c[d(1-NH2)beta-AwF]. In summary, these results suggest that alternative interactions might duly replace the electrostatic interaction of the protonated nitrogen with the Asp residue, which has not to be considered a conditio sine qua non for opioid receptor activatio
APPLICATION OF COMPUTATIONAL METHODSTO THE DESIGN OF FATTY ACID AMIDE HYDROLASE(FAAH) INHIBITORS BASED ON A CARBAMICTEMPLATE STRUCTURE
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