1,721,104 research outputs found
Intact smallpox virus particles in an Italian mummy of the XVI century: an immuno-electron microscope study.
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Assessing EGFR mutations.
No full textRecent reports have noted the presence of novel mutations of the epidermal growth factor receptor (EGFR) gene in small samples of DNA extracted from paraffin-embedded sections or laser-microdissected specimens.1,2 Nagahara et al.1 reported EGFR mutations in colon carcinomas. These mutations were novel G→A or A→G transitions. Similarly, Tsao et al. (July 14 issue)2 report that 24 (53 percent) of the mutations they found in specimens of non–small-cell lung cancers were novel variant mutations; 22 (92 percent) of these mutations were C→T/G→A or A→G/T→C transitions. These mutations had not been reported previously in more than 2000 analyses for EGFR mutations performed on DNA extracted from pieces of frozen tumors
Silver enhancement of protein A-gold probes on resin-embedded ultrathin sections. An electron microscopic localization of mouse mammary tumor virus (MMTV) antigens.
No full textUltrastructural features of the intestinal absorption of mouse mammary tumor virus in newborn BALB/cfRIII mice.
No full textThe retrovirus mouse mammary tumor virus is present in mouse strains with a high incidence of mammary tumors as a causative agent. It is produced mainly in the mammary glands of sexually mature females and is milk-transmitted to newborns. The fate of the mouse mammary tumor virus is almost unknown. Where it enters, how it is distributed, and where it remains latent, remain unresolved problems. This study tries to answer the first of these questions. Viruses are for the most part digested in the stomach. Very few well-preserved B particles, i.e., the infective particles, are allowed to enter through a process of endocytosis, mainly in the newborn-type epithelial cells. These are epithelial cells with a very rich absorptive apparatus, characteristic of newborn rodents. The adult-type absorptive cells and the M cells of the Peyer's patches might be partly involved
Ultrastructural features of the intestinal absorption of mouse mammary tumor virus in newborn BALB/cfRIII mice.
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