1,720,969 research outputs found
Antimicrobial and bioactive scaffolds for tissue regeneration
No full textWith the aim to investigate different approaches for tissue regeneration, we tested various scaffolds sources and their bioactivity once enriching them with different type of bioactive molecules. The first project use 3D matrix enriched with hydroxytyrosol obtained by extraction from olive-oil
production wastes olive oil waste-water (OOWW) and olive oil filter cake (OOFC), and studies in vitro its bone regenerative effect. OOFC resulted in high cytotoxicity and small amount of hydroxytyrosol content, whereas OOFC proved not to affect cell viability and to have great antioxidant activity.
The second strategy focused on Platelet Rich Plasma (PRP) that positively affect bone regeneration. To cope with the frequent bone infection occurring in the fracture site, we studied in vitro and developed a PRP-fibrin scaffold enriched with silver-compounds recognized to have antibacterial
activity. They exerted great antibacterial and anti-biofilm activity on S. aureus, S. epidermidis and C. albicans while maintaining the differentiative activity on osteoblasts given by PRP. The third strategy exploited a multitude of factors of the adipose tissue niche evaluating its potential
to enhance wound healing. Results show that adipose tissue positively effects skin resident cells and secretes antibacterial factors in response to bacterial stimuli. Last strategy aim was to optimized culture conditions for in vitro microvasculature network formation. The optimal condition included 9% GelMa+ 4% PEG as gel composition whereas HlNECs selected as endothelial cells and adipo-derived MSCs as support cells. The chosen ratio 1: 1, no GFs and no FBS in the media were the other condition that enable elongated structure network formation throughout the gel.
Our work investigated different tissue regeneration strategies for different tissue, although further studies are required, it proposes new insights and approaches in this constantly evolving field.With the aim to investigate different approaches for tissue regeneration, we tested various scaffoldssources and their bioactivity once enriching them with different type of bioactive molecules.The first project use 3D matrix enriched with hydroxytyrosol obtained by extraction from olive-oilproduction wastes olive oil waste-water (OOWW) and olive oil filter cake (OOFC), and studies invitro its bone regenerative effect. OOFC resulted in high cytotoxicity and small amount ofhydroxytyrosol content, whereas OOFC proved not to affect cell viability and to have greatantioxidant activity.The second strategy focused on Platelet Rich Plasma (PRP) that positively affect bone regeneration.To cope with the frequent bone infection occurring in the fracture site, we studied in vitro and• developed a PRP-fibrin scaffold enriched with silver-compounds recognized to have antibacterialactivity. They exerted great antibacterial and anti-biofilm activity on S. aureus, S. epidermidis andC. albicans while maintaining the differentiative activity on osteoblasts given by PRP.The third strategy exploited a multitude of factors of the adipose tissue niche evaluating its potentialto enhance wound healing. Results show that adipose tissue positively effects skin resident cells andsecretes antibacterial factors in response to bacterial stimuli.Last strategy aim was to optimized culture conditions for in vitro microvasculature networkformation. The optimal condition included 9% GelMa+ 4% PEG as gel composition whereasHlNECs selected as endothelial cells and adipo-derived MSCs as support cells. The chosen ratio1: 1, no GFs and no FBS in the media were the other condition that enable elongated structurenetwork formation throughout the gel.Our work investigated different tissue regeneration strategies for different tissue, although furtherstudies are required, it proposes new insights and approaches in this constantly evolving field
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Per una critica all’uso della ‘vulnerabilità’ nelle politiche su migrazione e asilo
No full textIn the current public debate on asylum and migration, there is a growing emphasis on the need to protect the most vulnerable - such as minors, pregnant women, LGBTQI people, people with disabilities and women victims of gender-based violence. In fact, the concept of ‘vulnerability’ is playing an increasingly central role in migration and international protection policies, first and foremost at borders and in protection claim procedures, but also in programmes for the resettlement or relocation of refugees in countries of the global South
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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