1,720,987 research outputs found
Effects of controlled-release formulations of atypical antipsychotics on functioning and quality of life of schizophrenic individuals.
No full textINTRODUCTION: Controlled-release formulations of atypical antipsychotics have
recently been introduced into clinical practice. Clinical studies have indicated
that these new therapies induce meaningful improvements in the functioning and
quality of life of schizophrenic individuals. AREAS COVERED: The present analysis
makes an attempt to address the clinical relevance of these studies and their
contribution to the understanding of the mechanisms of action of these new drugs.
A Medline search was done using the keywords 'antipsychotic', 'plasma level',
'quality of life' and 'functioning'. EXPERT OPINION: After reviewing the
literature, it seems that symptom control and side effects may play a role in
modulating the functioning and quality of life of schizophrenic individuals
treated with controlled-release formulations of atypical antipsychotics. The
analysis also highlights that these new drugs may possess peculiarities and
similarities in regulating patient functioning. However, the low number of
clinical analyses that have focused on these aspects of antipsychotic therapy
limits the interpretation of the results. Additional comparative clinical trials
are needed to evaluate how the pharmacokinetic/pharmacodynamic properties of
antipsychotic drugs may modulate the functioning and quality of life of
schizophrenic individuals, as well as to establish whether new clinical benefits
may come from the use of these drugs in schizophrenia therapy
Different affinity of cortical GHB binding sites in sardinian alcohol-preferring (sP) and -non preferring (sNP) rats
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Delta-9-tetrahydrocannabinol differently affects striatal c-Fos expression following haloperidol or clozapine administration. Eur J Pharmacol. 2008 Nov 19;598(1-3):16-20
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