309,702 research outputs found
Letter of Introduction from ME Marchant to CE Marchant, Newcastle ND
No full textA letter from Mary Elizabeth Marchant to Charles E Marchant, introducing Dr GF Story to the latter (ND). Story was embarking on a mission visit, and Mary had advised him to call upon Charles when he arrived. From Cotton Family Papers C7/139
GENOMICS AND ENVIRONMENTAL REGULATION: SCIENCE, ETHICS, AND LAW
No full textPreface -- List of contributors -- Introduction: environmental policy in the age of genomics / Richard R. Sharp, Gary E. Marchant, and Jamie A. Grodsky -- Pt. I. Environmental policy perspectives -- 1. Toxicogenomics and environmental regulation / Gary E. Marchant -- 2. Addressing genomic needs at the U.S. Environmental Protection Agency / Kerry L. Dearfield, William H. Benson, Kathryn Gallagher, and Jeremy D. Johnson -- 3. Application of genomics for health and environmental safety of chemicals: an industry perspective / Richard D. Phillips -- 4. Toxicogenomics and the public interest: technical and sociopolitical challenges / John M. Balbus -- Pt. II. Legal perspectives -- 5. Challenges in applying toxicogenomic data in federal regulatory settings / Lynn L. Bergeson -- 6. Genetic data and toxic torts: intimations of statistical reductionism / Andrew Askland and Gary E. Marchant -- 7. Genomics and environmental justice: some preliminary thoughts / Gary E. Marchant and Jamie A. Grodsky -- 8. Setting air quality standards in the postgenomic era / Gary E. Marchant -- Pt. III. Occupational health perspectives -- 9. Genetics and workplace issues / Paul A. Schulte -- 10. Advances in human genome epidemiology: implications for occupational health and disease prevention / Marc Weinstein -- 11. Occupational health and discrimination issues raised by toxicogenomics in the workplace -- Mark A. Rothstein -- 12. Genetic susceptibility and radiological health and safety / Kenneth L. Mossman -- Pt. IV. Ethical and philosophical perspectives -- 13. Conceptual and normative dimensions of toxicogenomics / Andrea O. Smith and Jason Scott Robert -- 14. Enviromental disease, biomarkers, and the precautionary principle / David B. Resnik -- 15. Rights and the exceptionally vulnerable / James W. Nickel -- 16. (Almost) equal protection for genetically susceptible subpopulations: a hybrid regulatory-compensation proposal / Carl Cranor -- 17. Protecting people in spite of or thanks to the "veil of ignorance" / Adam M. Finkel -- Appendix: Executive summary of National Research Council Report, Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment -- Inde
Tribunal sacramentale & visibile animarum in hac vita mortali, tomis tribus explicatum
No full textAuctore R. P. F. Petro Marchant Covviniensi ... ; Accedvnt Ad Calcem Resolvtiones Variorum Casuum, & Quæstionum practicarum, a multis hactenus desideratæTitelblatt in Rot-Schwarz-DruckAus dem Vorbesitz des Klosters Rheinau, Verbalexlibris auf dem Titelblat
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Author, publisher and bookseller : a tripartite synergy in Nigerian book industry
No full textThis work is about the roles of Author, Publisher and Bookseller in Book development in
Nigeria. The paper started by delving into the history of Book Publishing in Nigeria after
which it proceeded by defining who an author, a publisher, and a bookseller is and
expatiated on the indispensable roles of these key actors in Nigerian Book Industry and in
the emerging Information Society. Furthermore, the various constraints to book
development were identified while the paper advised on how the Book Industry can be
further promoted in Nigeria. However, the paper concluded and made recommendations
on how the Book sector can help in enhancing scholarship in the country
Conservation of the 2-keto-3-deoxymanno-octulosonic acid (Kdo) biosynthesis pathway between plants and bacteria
No full textThe increasing prevalence of multi-drug resistant bacteria is driving efforts in the development of new antibacterial agents. This includes a resurgence of interest in the Gram-negative bacteria lipopolysaccharide (LPS) biosynthesis enzymes as drug targets. The six carbon acidic sugar 2-keto-3-deoxymanno-octulosonic acid (Kdo) is a component of the lipid A moiety of the LPS in Gram-negative bacteria. In most cases the lipid A substituted by Kdo is the minimum requirement for cell growth, thus presenting the possibility of targeting either the synthesis or incorporation of Kdo for the development of antibacterial agents. Indeed, potent in vitro inhibitors of Kdo biosynthesis enzymes have been reported but have so far failed to show sufficient in vivo action against Gram-negative bacteria. As part of an effort to design more potent antibacterial agents targeting Kdo biosynthesis, the crystal structures of the key Kdo biosynthesis enzymes from Escherichia coli have been solved and their structure based mechanisms characterized. In eukaryotes, Kdo is found as a component of the pectic polysaccharide rhamnogalacturonan II in the plant primary cell wall. Interestingly, despite incorporating Kdo into very different macromolecules the Kdo biosynthesis and activation pathway is almost completely conserved between plants and bacteria. This raises the possibility for plant research to exploit the increasingly detailed knowledge and resources being generated by the microbiology community. Likewise, insights into Kdo biosynthesis in plants will be potentially useful in efforts to produce new antimicrobial compounds
- …
