102,126 research outputs found
Reduced lung cancer mortality with increasing dairy farming exposure: is endotoxin the key factor?
No full textAmerican Journal of Industrial Medicine; 30, pp.601-60
Valutazione comparativa dell`osteotomia femorale e del "borrage" con calcitonina e spongostan nel trattamento chirurgico conservativo dell`osteonecrosi della testa femorale
No full text
All cats are gray in the dark or: not all NSAIDs give adverse reactions. A case report.
No full textBackground: Intolerance to acetylsalicilic
acid (ASA) and nonsteroidal antiinflammatory
drugs (NSAIDs) is a crucial problem in
medical practice. The prevalence of NSAIDs
intolerance is estimated as 0.6–2.5 in the
general population, rising to over 10–20% in
asthmatic patients. In general practice,
NSAIDs are always supposed to cross-react
with each other. Because the use of ASA as
platelet antiaggregant is mandatory in many
cardiological diagnostic and therapeutic
procedures, ASA intolerance is a common
and a severe problem in Coronary Intensive
Care Unit (CICU). Here we describe the
case of a Diclofenac intolerant patient who
tolerates ASA treatment without any reaction.
Case Report: A 57 years old male patient,
affected with mild hypertension and osteoarthritis
suffered a severe anaphylaxis
after the application of a Diclofenac suppository.
A few minutes after the drug
application he had symptoms of glottis
oedema and rapidly fell unconscious. The
rescue team found him pulseless. He underwent
to resuscitation procedures with success.
Then, he was admitted into the CICU
and the tests performed there showed: nonspecific,
diffused alterations of the repolarization
(DII, DIII; V3-V6) at the electrocardiogram;
a mild increment of troponine I
(maximum 3.17 mg/L); no pathological findings
at the echocardiography. The ventricular
coronarography showed a 95% stenosis
of a collateral vessel of the right coronary
artery that underwent to a successful placement
of a drug-eluting stent. Chest X-Ray,
ultrasound scans of the abdomen and of the
chest, and brain Computer Tomography
were normal. When he was in CICU he
was started on therapy with ASA 100 mg
daily under medical control. He tolerated
ASA without any complication during all
the eleven days of hospitalization. The
allergy consultant suggested to avoid stopping
the therapy with ASA and to avoid
taking Diclofenac, Aceclofenac and any
other NSAIDs, apart from paracetamole in
the future. This case demonstrates that
patients with severe Diclofenac hypersensitivity
could tolerate other NSAIDs, in
particular ASA, mandatory in some medical
procedures. Other authors (1) described
tolerance of indomethacin, piroxicam,
methamizole but not ASA in 12 Diclofenac
hypersensitive patients.
Conclusion: In conclusion, patients referring
previous reactions to NSAIDs should not be
a priori excluded from treatment requiring
ASA
Natural latex allergy. Patient management: from clinic to prevention. A review Allergia a latice naturale. Gestione del paziente: dalla clinica alla prevenzione. Rassegna critica
No full textAbstract
The widespread use of latex devices has been followed, in the last 25 years, by an increase in IgE mediated sensitization. The clinical manifestations of latex allergy affect the skin (urticaria and angioneurotic oedema), the lower and the upper respiratory tracts (rhinoconjunctivitis, asthma and glottis oedema), and the cardiovascular system (anaphylaxis). There is also an anaphylactic risk during surgery and invasive diagnostic procedures. Vegetable food cross-reacts with latex so that more than half of the patients show specific IgE against some food. Further than traditional groups at risk, as health care workers, other work categories have to be protected, because of the inappropriate use of latex gloves (food or drug industry workers, mechanics, panel beaters and so on). Recently the latex most important allergenic fractions have been characterized and recombinant allergens are now available. The recombinant allergens allow a better standardization of the extracts for diagnostic use, the production of safer extracts for immunotherapy as well as a more accurate evaluation of food cross-reactions. The recombinant allergens will allow a more accurate dosage of latex concentrations in air and in objects and, in future, to establish threshold limit values. The main aims of prevention are the replacement of latex with alternative elastomers, the reduction of work and extra work exposure and an efficient health survey in working environment. The use of latex gloves and devices among general population has to be discouraged. Specific immunotherapy has to be considered a second choice and restricted to highly qualified workers in order to realize a rehabilitation to their previous jobs. The actually obtained protection must be verified
Epidemiology of chronic non-specific lung disease in a population exposed to isocyanate. II: Analysis of respiratory impairment.
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