199 research outputs found
MCR-1: rethinking the origin
No full textFil: Di Conza, José Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Radice, Marcela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Gutkind, Gabriel Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentin
Intercontinental dissemination of IMP-13-producing Pseudomonas aeruginosa belonging in Sequence Type 621
No full textIMP-type metallo-β-lactamases (MBLs) were the first acquired MBLs detected in Gram-negative pathogens, in the early 1990s, and are among the most relevant due to their worldwide distribution.Fil: Santella, Gisela Natalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Pollini, Simona. Universita Degli Studi Di Siena; ItaliaFil: Docquier, Jean-Denis. Universita Degli Studi Di Siena; ItaliaFil: Mereuta, Ana Irina. Universitatea de Medicina si Farmacie “Grigore T. Popa”; RumaniaFil: Gutkind, Gabriel Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Rossolini, Gian Maria. Universita Degli Studi Di Siena; ItaliaFil: Radice, Marcela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentin
Letture gramsciane di Giuseppe Lombardo Radice (II parte)
No full textIn Gramsci’s intellectual development is not a place on the periphery is occupied by the figure of Lombrado Root. Prominent character of pedagogy idealism and importer in Italy, activist of instances (even American), socialist “romantic, sentimental, unscientific.” Lombardo Radice was a careful student of the drama of the South and Gramsci was always very interested in the work of the Sicilian and there are many similarities (apparent) between the two intellectuals: 1) the focus on popular culture, 2) the combination between educational and political problems, and 3) the reference to the figure of Leonardo and other similarities yet. The author has done a thorough research work and significant
Radice: Data-driven Risk Analysis of Sustainable Cloud Infrastructure using Simulation
No full textCloud datacenters underpin our increasingly digital society, serving stakeholders across industry, government, and academia. These stakeholders have come to expect reliable operation and high quality of service, yet demand low cost, high scalability, and corporate (environmental) responsibility. Datacenter operators are confronted frequently with highly complex decisions that involve numerous aspects of risk. The consequence of bad decisions can be financial penalties or even loss of customers on the one hand, or a competitive disadvantage or unsustainable environmental impact on the other hand. Despite risk analysis being an integral part of the design and operation of cloud infrastructure, relatively few comprehensive approaches and tools exist, leaving many datacenter operators ill-equipped to make informed decisions with confidence.We propose Radice, an instrument for data-driven analysis of IT-related operational risks in sustainable cloud datacenters. Unlike most state-of-the-art approaches used by the industry, Radice automates the process of risk analysis in datacenters and utilizes the large and diverse volume of data reported by the monitoring systems in datacenters, including environmental data. Underpinning this system is the trace-based, discrete-event simulator OpenDC, which enables the exploration of many risk scenarios through its support for diverse workloads, datacenter topologies, and operational phenomena. Radice’s interactive and explorative user interface assists datacenter operators in addressing complex decisions involving risks, providing them with actionable insights, automated visualizations, and suggestions to reduce risk.We implement Radice and conduct a comprehensive evaluation of the system to demonstrate how it can aid datacenter operators when confronted with fundamental risk trade-offs. Although Radice is designed to work across many kinds of datacenters, in this work, we focus on private-cloud, business-critical workloads, and on public-cloud operations, representing the majority of workloads in Dutch datacenters. Our experiments show many interesting findings, supporting our claim for a need for data-driven risk analysis in datacenters. We highlight the increasing risk faced by datacenter operators due to price surges in the electricity and CO2 bond markets, and demonstrate how Radice can be used to control such risks. We further show that Radice can automatically optimize topology and operational settings in datacenters for risk, revealing configurations that reduce the overall risk by 10%–30%. Following extensive performance engineering, Radice is able to evaluate risk scenarios by a factor 70x–330x faster than others, opening possibilities for interactive risk exploration. We release Radice as free and open-source software for the community to inspect and re-use.Computer Scienc
Designing for Audience Participation within Museums: Operative Insights from the Exhibit Everyday History
No full textThis paper aims at exploring the shifting from the role of museums as provider of contents and designer of experience, to the role of facilitator of experiences around contents, as the emergence of new patterns for culture transmission opened to new possibilities for participatory approaches in the design of heritage experiences. Starting from the description of the participatory exhibit “Everyday History,” designed by the author at the Santa Cruz Museum of Art and History, CA, United States, as part of her doctoral research, this paper outlines methods and tools for the design of effective participatory experiences, capable of catalyzing visitor voices in supporting and contributing to cultural experiences. This approach has the goal to change the traditional top down way of communicating to the visitors, in favor of a multidirectional flow of information between the cultural institutions and the audience. Insights from this case study and literature highlight that designing for participation, in which community engagement is the final outcome of the design process, does not necessarily implies—but does not exclude—participatory design processes. The author proposes a design methodology led by institutional staff, in which visitors are involved in recursive evaluation phases, conceiving the exhibition itself as an ongoing and never-finished product
Enterobacterias con resistencias emergentes : caracterización feno y genotípica y evaluación de la actividad de viejos y nuevos antimicrobianos
No full textEnterobacteriaceae isolates from patients admitted at Hospital de Clínicas "José de San Martin" were studied during the period 2009-2013. The CTX-M type ESBL represents the main mechanism of resistance to extended spectrum cephalosporins although we observed a change in the epidemiology given by the higher prevalence of enzymes belonging to the CTX-M-1 group causing a polyclonal spread. The presence of KPC-type carbapenemase represents the most prevalent resistance to carbapenems. K. pneumoniae- KPC- producing isolates emerged sporadically and the caused a monoclonal dissemination associated to ST258. In the last years the resistance spread to other Enterobacteriaceae and also to other STs in K. pneumoniae. Colistin- resistance emerged in KPC-producing K. pneumoniae due to the selection of resistant subpopulations; and in the KPC- negative isolates associated to a dispersion of resistant clones. The previous use of colistin represents the main risk factor for the acquisition and would facilitate the selection of resistant subpopulations. The colistin/rifampicin association was the most active in vitro combination in isolates susceptible and resistant to colistin and was used in same patients with good results.Fil: Nastro, Marcela Bettina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaSe estudiaron aislamientos de enterobacterias de pacientes atendidos en el hospital de Clínicas "José de San Martin" durante los años 2009- 2013. La presencia de BLEE de tipo CTX-M es el mecanismo principal de resistencia a cefalosporinas de espectro extendido; pero se observó un desplazamiento de BLEEs de tipo CTX-M-2 por enzimas del grupo CTX-M-1, asociado a una diseminación multiclonal. El mecanismo de resistencia a carbapenemes más prevalente fue la presencia de carbapenemasa de tipo KPC. Los aislamientos portadores del gen blaKPC, surgieron esporádicamente causando brotes aislados y luego se observó una diseminación monoclonal en K. pneumoniae asociada al ST258. Posteriormente se detectó la diseminación a otras especies de enterobacterias y a otros secuenciotipos de K. pneumoniae. La resistencia a colistina emergió en K. pneumoniae con KPC debido a la selección de las subpoblaciones resistentes en el clon epidémico, y en los aislamientos KPC negativos por dispersión de clones resistentes. El uso previo es el principal factor relacionado con la adquisición y facilitaría la selección de subpoblaciones resistentes. La asociación colistina/ rifampicina demostró ser la combinación más activa in vitro, en aislamientos portadores de KPC sensibles y resistentes a colistina y fue utilizada en el hospital con buenos resultados clínicos.Doctora de la Universidad de Buenos Aires en Microbiologí
Prevalence of Plasmid Mediated Quinolone Resistance Determinants among Oxyiminocephalosporin Resistant Enterobacteriaceae in Argentina.
No full textHigh quinolone resistance rates were observed among oxyiminocephalosporin resistant enterobacteria. In the present study, we searched for the prevalence of plasmid mediated quinolone resistance (PMQR) genes within the 55 oxyiminocephalosporin resistant enterobacteria collected in a previous survey. The main PMQR determinants were aac(6´)-Ib-cr and qnrB corresponding to 42.4% and 33.3%, respectively. aac(6?)-Ib-cr was more frequently present in CTX-M-15 producing isolates, while QnrB was homogeneously distributed in all CTX-M producers.Fil: Rincón Cruz, Giovanna. Universidad Industrial Santander; Colombia;Fil: Radice, Marcela Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina;Fil: Sennati, Samanta. Consejo Nacional de Investigaciones Científicas y Técnicas . Oficina de Coordinación Administrativa Houssay. Instituto de Inmunologia, Genetica y Metabolismo; Argentina;Fil: Pallecchi, Lucia. Università de Sienna; Italia;Fil: Rosollini, Gian Maria. Università de Sienna; Italia;Fil: Gutkind, Gabriel Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas . Oficina de Coordinación Administrativa Houssay. Instituto de Inmunologia, Genetica y Metabolismo; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;Fil: Di Conza, José Alejandro. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiologia. Cátedra de Microbiología Parasitología e Inmunologia; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Identification of CfiA coding genes in Bacteroides fragilis isolates recovered in Argentina. Inconsistencies in CfiA organization and nomenclature
No full textCfiA (CcrA) metallo-β-lactamase is the main carbapenem resistance mechanism in B. fragilis. From cfiA positive isolates detected in a previous surveillance study, 3 displayed resistance to imipenem while the remaining were susceptible. The aim of this study was to identify the cfiA alleles and to analyze the presence of IS elements in their upstream regions. CfiA-1, CfiA-4, CfiA-13, CfiA-19 and CfiA-22 were detected. IS elements belonging to IS21 family and IS942 group were identified upstream to cfiA in the 3 imipenem resistant isolates. We present an exhaustive analysis of cfiA/CfiA registers in databases, illustrating the inconsistencies in both organization and nomenclature. According to this analysis CfiA family comprises nowadays 15 different CfiA variants coded by 24 cfiA sequences. Curation of CfiA database is mandatory, if not new cfiA admission at GenBank will contribute to make this classification more complex.Fil: Litterio, Mirta R.. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Cejas, Daniela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gutkind, Gabriel Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Radice, Marcela Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
Philo's Theology and Theory of Creation
No full textPhilo’s theology is expressed by a few basic concepts – such as Logos, the Powers, Pnuema and the Ideas – through which the relation between God and the world is explained. But the same relation is explained in the act of Creation, such as it is presented in the Bible. Philosophically speaking, this act fluctuates between an “ex nihilo” interpretation and a demiurgic one. According to the author, Philo’s notion of creation has a mixed nature: “ex nihilo” in the planning stage (the world of the Ideas reflects the first day of creation in the Genesis) and demiurgic in the executive stage. Therefore, is there another (material) principle next to God? Philo provides no conclusive answer, because in this case he is always under the influence of a Platonic vision, according to which matter and the evil connected with it are non-being and only the Ideas are true being
First clonal spread of KPC-producing Pseudomonas aeruginosa in Buenos Aires, Argentina
No full textFil: Santella, Gisela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Cittadini, Roxana. Sanatorio Mater Dei; ArgentinaFil: Papalia, Mariana Andrea. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vera Ocampo, Cecilia. Sanatorio Mater Dei; ArgentinaFil: Del Castillo, Marcelo. Sanatorio Mater Dei; ArgentinaFil: Vay, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Sanatorio Mater Dei; ArgentinaFil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Radice, Marcela Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
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