100,569 research outputs found
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Sciare in Italia in tempo di pace e in tempo di guerra (1914-18)
No full textIl saggio mette in evidenza le pratiche legate allo scialpinismo prima e durante la I guerra mondial
Kinesiophobia and depression affect total knee arthroplasty outcome in a multivariate analysis of psychological and physical factors on 200 patients
No full textPurpose To evaluate the effects of kinesiophobia on the
outcomes of total knee arthroplasty (TKA), and to investigate
whether kinesiophobia represents an independent factor
influencing the surgery success or whether the observed
effects are driven by other physical or psychological
aspects such as anxiety and depression.
Methods Two hundred patients were evaluated prospectively
(mean age 65.7 ± 9.1 years, 134 women and 66 men) at
12 months after TKA. Kinesiophobia was assessed with the
Tampa Scale for kinesiophobia (TSK: Activity Avoidance—
TSK1 and Harm—TSK2 subscales); anxiety and depression
were assessed with STAI and BDI, respectively, and preoperative
pain and function, sex, age, BMI, education level, number
of painful joints and years of symptoms’ duration before
surgery were documented as well. Results were evaluated
with pain and function on 0–10 numeric rating scales, while
the overall clinical outcome was documented with WOMAC
and SF-12 (Physical and Mental subscales) scores.
Results TSK1 was correlated with WOMAC results at
12 months (p = 0.005, ρ = 0.197). STAI (p = 0.002,
ρ = 0.222), BDI (p < 0.0005, ρ = 0.307), and sex (p = 0.004) also influenced the outcome after TKA, while
other parameters, such as age, BMI, education level, and
number of painful joints and years of symptoms’ duration
before surgery, did not correlate with the clinical outcome.
The multivariate analysis confirmed the role of BDI
(p = 0.006, partial η2 = 0.038), TSK1 (p = 0.011, partial
η2 = 0.033), and sex (p = 0.048, partial η2 = 0.020), and
a synergic interaction of BDI and TSK1, which together
presented an even stronger correlation (p < 0.0005, partial
η2 = 0.111) with WOMAC at 12-month follow-up.
Conclusions Kinesiophobia is a factor influencing the outcome
after TKA independently from other psychological
and physical variables. This risk factor may affect TKA
results, especially in women, and shows a further synergic
interaction with depression in terms of lower surgical outcome.
These findings are of clinical relevance because they
show the impact of psychological factors such as kinesiophobia,
and suggest the possibility of adopting co-interventions
to overcome the fear of physical activity, and in the
end improve patient recovery and final outcome after TKA.
Level of evidence IV
Tesi di Platone sulla ragion politica del processo a Socrate e sulla natura della sua attività propagandistica ’, in AA.VV., Il quinto secolo, Studi di filosofia antica in onore di Livio Rossetti, a cura di S. Giomb‘Tesi di Platone sulla ragion politica del processo a Socrate e sulla natura della sua attività propagandistica Passignano 2010, pp. 519-528
No full textAnalysis of the knee rotation as predictor factor for postoperative laxity after acl reconstruction
No full textEvaluation of the sealing function of the acetabular labrum: an in vitro biomechanical study
No full textPurpose: To quantitatively evaluate the biomechanical sealing function of an intact labrum and the effect of labral-chondral separation, cerclage suture labral repair, vertical mattress suture repair and partial labrectomy on distraction load and hip joint centre (HJC) displacement.
Methods: Eight fresh-frozen cadaveric hips were tested using a navigation system for intra-operative kinematic analysis. A six-axis load cell was used to measure the manually applied force when performing the tests: hip pivoting movement and distraction. The HJC displacement that occurred during the distraction test has been evaluated in correspondence of seven different values of applied force. During the pivoting motion, the maximum value of HJC displacement was evaluated. Five different conditions were tested: labrum intact, labral-chondral separation, vertical mattress suture repair, cerclage suture repair, and partial labrectomy.
Results: With regard to HJC displacement using at fixed value of force, the paired sample t test underscored the statistically significant differences (p < 0.05) for each of the five tested conditions among themselves. Only the comparison of intact versus labral-chondral separation was not significantly different. During pivoting motion, a statistically significantly greater displacement was identified after labrectomy when compared with the cerclage suture repair (p = 0.03) and vertical mattress repair (p < 0.01) in medial-lateral direction. Along proximal-distal direction, a significant lower displacement after labrectomy was identified when compared to the cerclage suture repair (p = 0.03). Performing the pivoting motion at the extreme ranges of motion demonstrated a higher value of displacement after labrectomy when compared with all the previously tested conditions.
Conclusions: These results suggest that labral repair is important in the function of the hip and that the vertical mattress suture technique may be better than the cerclage suture repair
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Senofane critico dell’antropomorfismo
No full textRiprendendo la celebre critica di Senofane all’antropomorfismo, si esamina l’eventualità di un confronto con esperienze culturali non greche e con la tradizione orientale
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