1,079 research outputs found
Les portraits de couples sur les reliefs funéraires du monde romain et au XXe siècle : les prises, égalité et asymétries
No full textPeeters Marc C. Les portraits de couples sur les reliefs funéraires du monde romain et au XXe siècle : les prises, égalité et asymétries. In: Dialogues d'histoire ancienne, vol. 32, n°2, 2006. pp. 95-124
L'évolution du mythe d'Europe dans l'iconographie grecque et romaine des VIIe-VIe s. avant aux Ve-VIe s. de notre ère : de la « déesse au taureau » au rapt et du rapt au consentement
No full textPeeters Marc C. L'évolution du mythe d'Europe dans l'iconographie grecque et romaine des VIIe-VIe s. avant aux Ve-VIe s. de notre ère : de la « déesse au taureau » au rapt et du rapt au consentement. In: Dialogues d'histoire ancienne, vol. 35, n°1, 2009. pp. 61-82
Gastrointestinal motility disorders in children: etiology and associated behaviors
No full textGenetisch koppelingsonderzoek en het bestuderen van niet-geïsoleerde motiliteitsstoornissen (problemen met de motoriek van darmen of maag) bevestigen de klinische en genetische heterogeniteit van deze aandoeningen. Behalve omgevingsfactoren blijken ook gedragingen van het kind en karakteristieken van ouders geassocieerd met motiliteitsstoornissen op de kinderleeftijd. In haar proefschrift ontrafelt Babette Peeters de rol van genetische factoren, omgevingsfactoren en gedrag in de ontstaanswijze van de meest voorkomende motiliteitsstoornissen bij kinderen. Problemen met de motoriek van darmen of maag (de motiliteit) worden gezien bij kinderen van alle leeftijden. De meest voorkomende stoornissen op kinderleeftijd zijn reflux, afsluiting van de maaguitgang en problemen met de stoelgang. Er is weinig bekend over het ontstaan van deze stoornissen
Dilemma in metastatic colorectal cancer: VEGF versus EGRF targeting
No full textThe modern approach for metastatic colorectal cancer (mCRC) patients is based on the identification of oncogenic pathways, which could be targeted by specific molecules. Vascular endothelial growth factor (VEGF)-and epithelial growth factor receptor (EGFR)-related pathways represent the most important biological mechanisms for cancer development and progression. However, the most significant results by VEGF and EGFR targeting could be achieved through the combination of these drugs with standard chemotherapeutic regimens. These strategies aim to improve the resectability of liver and lung metastases. For those patients who cannot be eligible for metastases resection, a 'continuum of care' has been proposed as the best option. This strategy includes the sequential delivery of various regimens with different targeted drugs. For this reason the choice of the pathway to target, that is, VEGF or EGFR, is not a real dilemma since both these molecules would be targeted during the mCRC natural history. To date, a selection by KRAS mutational status is mandatory to identify those patients with higher probability of benefit from anti-EGFR monoclonal antibodies. In this case VEGF targeting is the only way to choose. New molecules are under evaluation to widen these treatment options. © Informa UK, Ltd
How to find the Ariadne's thread in the labyrinth of salvage treatment options for metastatic colorectal cancer?
No full textSince a chance for cure was found out in metastatic colorectal cancer (mCRC)
patients undergoing a resection of liver and lung metastases, high tumor
shrinkage by chemotherapy regimens and their combination with targeted
agents have been addressed in potentially resectable mCRC. However, most
mCRC patients cannot reach this opportunity because of tumor burden or
metastatic sites. For these patients a salvage systemic therapy could be offered
to prolong survival. To date, a huge number of clinical trials provided some
evidences for the achievement of this goal. A lot of chemotherapeutic regimens
in combination with biological therapies are now available. We tried
to propose a simple way to choose the best options and to plan an optimal
sequence of treatments. This tool could help the oncologists worldwide to
better and easily manage mCRC patients who need salvage systemic therapy
24-month data from the BRAVISSIMO: A large-scale prospective registry on iliac stenting for TASC A & B and TASC C & D lesions
No full textBackground To evaluate the 24-month outcome of stenting in Trans-Atlantic Inter-Society Consensus (TASC) A & B and TASC C & D iliac lesions in a controlled setting. Methods The BRAVISSIMO study is a prospective, nonrandomized, multicenter, multinational, monitored registry including 325 patients with aortoiliac lesions. The end point is the primary patency at 24 months, defined as a target lesion without a hemodynamically significant stenosis on duplex ultrasound (>50%, systolic velocity ratio >2.0). A separate analysis for TASC A & B versus TASC C & D population is performed. Results Between July 2009 and September 2010, 190 patients with TASC A or B and 135 patients with TASC C or D aortoiliac lesions were included. The demographic data were comparable for TASC A & B cohort and TASC C & D cohort. Technical success was 100%. Significantly more balloon-expandable stents were deployed in TASC A & B lesions, and considerably more self-expanding stents were placed in TASC C & D (P = 0.01). The 24-month primary patency rate after 24 months for the total population was 87.9% (88.0% for TASC A, 88.5% for TASC B, 91.9% for TASC C, and 84.8% for TASC D). No statistically significant difference was shown when comparing these groups. The 24-month primary patency rates were 92.1% for patients treated with the self-expanding stent, 85.2% for patients treated with the balloon-expandable stent, and 75.3% for patients treated with a combination of both stents (P = 0.06). Univariate and multivariable regression analyses using Cox proportional hazards model identified only kissing stent configuration (P = 0.0012) and obesity (P = 0.0109) as independent predictors of restenosis (primary patency failure). Interestingly, as all TASC groups enjoyed high levels of patency, neither TASC category nor lesion length was predictive of restenosis. Conclusion The 24-month data from this large, prospective, multicenter study confirm that endovascular therapy may be considered the preferred first-line treatment option of iliac lesions, irrespectively of TASC lesion category
Victor Henry Kantien? Entretien avec C. Puech
No full textavec une bibliographie de Victor Henry par Marc Décim
Victor Henry Kantien? Entretien avec C. Puech
No full textavec une bibliographie de Victor Henry par Marc Décim
Dilemma in metastatic colorectal cancer: VEGF versus EGRF targeting
No full textThe modern approach for metastatic colorectal cancer (mCRC) patients is based on the identification of oncogenic pathways, which could be targeted by specific molecules. Vascular endothelial growth factor (VEGF)- and epithelial growth factor receptor (EGFR)-related pathways represent the most important biological mechanisms for cancer development and progression. However, the most significant results by VEGF and EGFR targeting could be achieved through the combination of these drugs with standard chemotherapeutic regimens. These strategies aim to improve the resectability of liver and lung metastases. For those patients who cannot be eligible for metastases resection, a 'continuum of care' has been proposed as the best option. This strategy includes the sequential delivery of various regimens with different targeted drugs. For this reason the choice of the pathway to target, that is, VEGF or EGFR, is not a real dilemma since both these molecules would be targeted during the mCRC natural history. To date, a selection by KRAS mutational status is mandatory to identify those patients with higher probability of benefit from anti-EGFR monoclonal antibodies. In this case VEGF targeting is the only way to choose. New molecules are under evaluation to widen these treatment options
Une disparition de l’auteur? La création impersonnelle
No full textThe question of the « disappearance » or the « death » of the author can be approached advantageously from the polarisations that seem to characterise artistic creation, in particular the pairs activity/passivity and individuality/universality. These tensions span the « history of creation », in which the question always arises of the participation of the author in relation to an external force which can, as it were, submerge and inspire him, but never leaves him in his empty autonomy. In this context the legacy and the challenge which the last century left us are precisely those of thinking the appearance of a paradoxical author, an « impersonal author », for whom the dynamic between these poles cannot be resolved by favouring one side at the expense of the other, but rather according to a new way which thinks below all dichotomous opposition.
According to this approach the author does die, but in the most elevated sense, i.e. to give life to an impersonal style, an instance foreshadowing an intersubjective perspective.La question sur la « disparition » ou la « mort » de l’auteur peut être abordée de manière bénéfique à partir des différentes polarisations qui
semblent caractériser la création artistique, notamment les couples activité/passivité et individualité/universalité. Ces tensions traversent l’« histoire de la création », dans laquelle se pose toujours la question de la participation de l’auteur par rapport à une force extérieure qui peut, pour ainsi dire, le submerger et l’inspirer, mais qui ne le laisse jamais dans sa vide autonomie. Dans ce cadre, l’héritage et le défi que nous a laissés le siècle dernier sont précisément de penser la figure d’un auteur paradoxal, un « auteur impersonnel » pour qui ladynamique entre ces pôles ne peut se résoudre en privilégiant un côté au détriment de l’autre, mais plutôt selon une nouvelle voie qui pense en deçà de toute opposition dichotomique. Selon cette approche, l’auteur meurt bien, mais dans
le sens le plus élevé, c’est-à-dire pour donner vie à un style impersonnel, une instance annonciatrice d’une perspective intersubjective
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