1,812 research outputs found
Dysphagia as a risk factor for mortality in Niemann-Pick disease type C: systematic literature review and evidence from studies with miglustat
No full textNiemann-Pick disease type C (NP-C) is a rare neurovisceral disease characterised by progressive neurological deterioration and premature death, and has an estimated birth incidence of 1:120,000. Mutations in the NPC1 gene (in 95% of cases) and the NPC2 gene (in approximately 4% of cases) give rise to impaired intracellular lipid metabolism in a number of tissues, including the brain. Typical neurological manifestations include vertical supranuclear gaze palsy, saccadic eye movement abnormalities, cerebellar ataxia, dystonia, dysmetria, dysphagia and dysarthria. Oropharyngeal dysphagia can be particularly problematic as it can often lead to food or fluid aspiration and subsequent pneumonia. Epidemiological data suggest that bronchopneumonia subsequent to food or fluid aspiration is a major cause of mortality in NP-C and other neurodegenerative disorders. These findings indicate that a therapy capable of improving or stabilising swallowing function might reduce the risk of aspiration pneumonia, and could have a positive impact on patient survival. Miglustat, currently the only approved disease-specific therapy for NP-C in children and adults, has been shown to stabilise key neurological manifestations in NP-C, including dysphagia. In this article we present findings from a systematic literature review of published data on bronchopneumonia/aspiration pneumonia as a cause of death, and on the occurrence of dysphagia in NP-C and other neurodegenerative diseases. We then examine the potential links between dysphagia, aspiration, pneumonia and mortality with a view to assessing the possible effect of miglustat on patient lifespan
Buying a computer for your farm or ranch
No full textBulletin no. 758 Moscow, Idaho :University of Idaho, College of Agriculture, Cooperative Extension System, 1994-06-01. Author(s): Patterson, P. E.; Gray, C. W.; Davis, A
SIMPLIFIED MODELING OF HIGH-J FAR-INFRARED AND MICROWAVE SPECTRA OF TETRAHEDRAL MOLECULES
No full text W. G. Harter and C. W. Patterson, J. Chem. Phys. 66, 4872-4885 (1977); C. W. Patterson and W. G. Harter, J. Chem. Phys. 66, 4886-4892 (1977). H. W. Galbraith, C. W. Patterson, B. J. Krohn, and W. G. Harter, J. Mol. Spectrosc. 73, 475-493 (1978).Author Institution:We use the and symmetric-top representations for rapidly rotating spherical-top molecules to approximate the clustered values of and diagonal coefficients with 3-J symbols. These coefficients then specify the intensities and wavenumbers, respectively, of absorption lines for the ``forbidden’’ pure rotational transitions in the vibrational ground state of tetrahedral molecules. We predict the absorption to be strongest for those states which correspond to rotation about the axes, and which satisfy the selection rule , Model spectra for (far-infrared) and (microwave) transitions will be shown
Letter from Raymond C. Patterson, Director of Internal Affairs, the American Legion, to Lillian Baker, October 21, 1983
No full textCopy of correspondence between the director of Internal Affairs at the American Legion and Lillian Baker with copies of rebuttals written by Lillian Baker against Japanese American reparations.The Japanese American Relocation Collection is composed of ephemera related to the relocation program during World War II. Items include the official government report of Manzanar Relocation Center, a photo album, post-war activism materials related to preserving and remembering the camps, various clippings, and documents. The strength of this collection is found in its many perspectives on the controversial relocation program and how it has been presented since World War II
ORDER, DISORDER, AND CLUSTERING IN ROTOR SPECTRA: A COMPARISON OF SPHERICAL AND ASYMMETRIC TOP
No full textAuthor Institution: Physics Department, Georgia Institute of Technology Atlanta; University of California, Los Alamos National Laboratory Theoretical Division Los AlamosThe techniques used to elucidate spherical top spectral clustering can be applied to other types of polyatomic molecules including those of low symmetry. Dynamical effective energy , can be drawn using the molecular constants in a general rotor Hamiltonian, and the surfaces can be used to calculate and understand the spectra and dynamics of the rotors. Spectral clustering effects such as rotational mixing of nuclear spin species are possible in asymmetric top molecules as well as in the spherical tops and The energy surfaces provide simple ways to calculate, predict, or rule out many such effects for a wide range of molecular species. We hope to show these surfaces in 3-D. Research supported in part by NSF grant PHY-8207150. W. G. Harter, C. W. Patterson, and F. J. daPaixao, Rev. Mod. Phys. 50, 37(1978). W. G. Harter and C. W. Patterson, J. Math. Phys. 20, 1453(1979). W. G. Harter, Phys. Rev. A24, 192(1981). J. Bord\’e, Ch. J. Bord\’e, C. Salomon, A. Van Lerberghe, M. Ouhayoun, and C. D. Cantrell, Phys. Rev. Lett. 45, 14(1980)
Literature And Spirit: Essays on Bakhtin and His Contemporaries
No full textIf Bakhtin is right, Wayne C. Booth has said, a very great deal of what we western critics have spent our time on is mistaken, or trivial, or both. In Literature and Spirit David Patterson proceeds from the premise that Bakhtin is right.
Exploring Bakhtin\u27s notions of spirit, responsibility, and dialogue, Patterson takes his reader from the narrow arena of literary criticism to the larger realm of human living and human loving. True to the spirit of Bakhtin, he draws the Russian into a vibrant dialogue with other thinkers, including Foucault, Berdyaev, Gide, Lacan, Levinas, and Heidegger. But he does not stop there. He engages Bakhtin in his own insightful and unique dialogue, meeting the responsibility and taking the risk summoned by dialogue.
Literature and Spirit, therefore, is not a typically cool and detached exercise in academic curiosity. Instead, it is a passionate and penetrating endeavor to respond to literature and spirit as the links in life\u27s attachment to life. The author demonstrates that in deciding something about literature, we decide something about the substance and meaning of our lives. Far from being a question of commentary or explication, he argues, our relation to literature is a matter of spiritual life and death. The reader who comes before a literary text encounters the human voice. And Patterson enables his reader to hear that voice in all its spiritual dimensions.
Unique in its questions and in its quest, Literature and Spirit addresses an audience that goes beyond the ordinary academic categories. It appeals not only to students of literature, philosophy, and religion, but to anyone who seeks an understanding of spiritual presence and meaning in life. Through his affirmation of what is dear, Patterson responds to the needful question. And in his response he puts the question to his audience: Where are you? Literature and Spirit thus speaks to those who face the task of answering, Here I am.
David Patterson, assistant professor of Russian at Oklahoma State University, is the author of The Affirming Flame: Religion, Language, Literature.
Patterson has had access to important untranslated texts from Bakhtin\u27s earliest period. From this perspective he is able to see what others, reading a partial Bakhtin, have not seen: that Bakhtin is a rather conservative thinker, more a \u27philosopher of life\u27 with roots in the pre-Romantics than a Marxist or a semiotician in twentieth-century parlance. —Philosophy and Literaturehttps://uknowledge.uky.edu/upk_slavic_languages_and_societies/1002/thumbnail.jp
The Crystal Structure of Selenourea at 20°C and ar -100°C
No full textTitle: The Crystal Structure of Selenourea at 20°C and ar -100°C, Author: John S. Rutherford, Location: ThodeThe trigonal form of selenourea has been
examined by X-ray crystallographic methods both at room temperature
and at a lower temperature ( -100°C) . The lattice parameters of
earlier workers have been refined and the space group assignment,
which requires nine crystallographically distinct SeC(NH2)2
molecules, confirmed. The crystal structure was solved using a
novel Patterson technique and differences Fourier syntheses, and
was refined by least squares using three - dimensional data obtained
0 at -100°C. Both the molecular dimensions and the crystal structure
found are compared to other members of the urea series, and the
similarity of the crystal structure to the urea- and thioureahydrocarbon
complexes discussed. Evidence is presented of N-H...Se
hydrogen bonds, supporting their recent discovery in chemically
related compounds.ThesisDoctor of Philosophy (PhD
Evidence for erbium-erbium energy migration in erbium(III) bis(perfluoro-p-tolyl)phosphinate
No full textCopyright 2008 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. This article appeared in Applied Physics Letters 92, 103303 (2008) and may be found at
The Google Book search settlement: A law and economics analysis
No full textBeginning in December 2004 Google has pursued a new project to create a book search engine (Google Book Search). The project has released a storm of controversy around the globe. While the supporters of Google Book Search conceive the project as a first reasonable step towards unlimited access to knowledge in the information age, its opponents fear profound negative effects due to an erosion of copyright law. Our law and economics analysis of the Book Search Project suggests that – from a copyright perspective – the proposed settlement may be beneficial to right holders, consumers, and Google. For instance, it may provide a solution to the still unsolved dilemma of orphan works. From a competition policy perspective, we stress the important aspect that Google’s pricing algorithm for orphan and unclaimed works effectively replicates a competitive Nash-Bertrand market outcome under post-settlement, third-party oversight.Book Rights Registry; Competition Policy; Copyright; Fair Use; Google Book Search; Library Program; Orphan Works
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