113 research outputs found
The mechanistic basis for psoriasis immunopathogenesis: translating genotype to phenotype. Report of a workshop, Venice, 2012
No full textThe International Psoriasis Council, a global nonprofit organization dedicated to advancing psoriasis research and treatment, led an initiative to better define the pathogenic mechanisms that constitute psoriasis. In September 2012, a workshop was held at the 42nd Annual European Society for Dermatological Research in Venice, Italy. By assembling a panel of global dermatology and immunology experts, the objective was to evaluate the current status of the science explaining the mechanism of disease in psoriasis, e.g. dysregulation of the skin immune system and perturbations of epidermal homeostasis. The workshop consisted of four oral presentations, which addressed key topics in psoriasis, delivered by Herve Bachelez (Paris, France), Antonio Costanzo (Rome, Italy), Michelle Lowes (New York, NY, U.S.A.) and Frank Nestle (London, U.K.). A global expert panel was assembled to stimulate dialogue and debate: Kevin Cooper (Cleveland, OH, U.S.A.), Michel Gilliet (Lausanne, Switzerland), Joerg Prinz (Munich, Germany), Martin Rocken (Tubingen, Germany), Jens Schroeder (Kiel, Germany), Manuelle Viguier (Paris, France), Mayte Suarez-Farinas (New York, NY, U.S.A.) and Cristina Zielinski (Berlin, Germany). Collectively, the presentations demonstrated the significant advances in understanding immune regulation that have occurred over the past decade by virtue of the study of psoriasis subtypes, phenotypic manifestations and genetic associations. Elucidating the pathogenic and genetic basis of psoriasis holds the promise of a complete understanding of disease mechanisms, predictors of treatment response, novel drug development strategies and customized therapeutic regimens for the individual patient
Efficacy and Safety of Tumor Necrosis Factor Inhibitors in Acute Generalized Pustular Psoriasis
No full textSuccessful Treatment of Generalized Pustular Psoriasis With the Interleukin-1-Receptor Antagonist Anakinra: Lack of Correlation With IL1RN Mutations
No full textMélanome métastatique et grossesse (prise en charge et devenir materno-fœtal)
No full textPARIS7-Xavier Bichat (751182101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
Etude des lymphocytes T régulateurs Cd4+CD25HIGH au cours du mélanome métastatique chez l'homme
No full textPARIS7-Bibliothèque centrale (751132105) / SudocSudocFranceF
Influence of oxide films on primary water stress corrosion cracking initiation of alloy 600
No full textIn the present study alloy 600 was tested in simulated pressurised water reactor (PWR) primary water, at 360 °C, under an hydrogen partial pressure of 30 kPa. These testing conditions correspond to the maximum sensitivity of alloy 600 to crack initiation. The resulting oxidised structures (corrosion scale and underlying metal) were characterised. A chromium rich oxide layer was revealed, the underlying metal being chromium depleted. In addition, analysis of the chemical composition of the metal close to the oxide scale had allowed to detect oxygen under the oxide scale and particularly in a triple grain boundary. Implication of such a finding on the crack initiation of alloy 600 is discussed. Significant diminution of the crack initiation time was observed for sample oxidised before stress corrosion tests. In view of these results, a mechanism for stress corrosion crack initiation of alloy 600 in PWR primary water was proposed
Relation between composition, microstructure and oxidation in iron aluminides
No full textThe relation between chemical composition, microstructure and oxidation properties has been investigated on various FeAl based alloys, the aim being to induce changes in the microstructure of the compound by selective oxidation of aluminium. Oxidation kinetics that was evaluated on bulk specimens showed that, due to fast diffusion in the alloys, no composition gradient is formed during the aluminium selective oxidation. Accordingly, significant aluminium depletion in the compound could be observed in the thinnest part of oxidised wedge-shape specimens. Another way to obtain samples of variable aluminium content was to prepare diffusion couples with one aluminide and pure iron as end members. These latter specimens have been characterised using electron microscopy and first results of oxidation experiments are presented
Long-term Efficacy of Dupilumab in Papulo-erythroderma of Ofuji
No full textAbstract is missing (Short communication
Treatment of Parvovirus B19–Associated Polyarteritis Nodosa with Intravenous Immune Globulin
No full text
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