260 research outputs found
Yi ge shufazhuiyizhe Luo Qi 一个书法主义者 洛齐 (A Practitioner of Calligraphyism: Luo Qi)
No full text在《一个书法主义者 洛齐》中,作者阐述了洛齐书法创作的心路历程,并仔细分析了书法主义的概念。
洛齐作为中国当代最重要、最有影响力的艺术家之一。在本书中,洛齐的创作风格和影响进行了比较全面的阐述和评析,见解深刻,评论精到。他的作品展现了书法作为一种多才多艺的艺术,并收到了西方艺术和中国现代书法的互相影响。在他的创作的同时,还以著述文章的方式思考着书法的未来。
书法主义是洛齐革命的艺术理论。在本书中,作者探索书法主义的理论与实践。以书法主义为探论主题,内容涉及书法主义的建构。作者也选录了近年来国内国外艺术家所创作的书法主义作品。
这本书分为五章:一、中国当代书法,二、洛齐艺术传记,三、洛齐作品解析,四、书法主义,五,洛齐艺术的访谈。《洛齐访谈录》包括洛齐访谈和有名艺术家谈洛齐艺术的访谈。读者通过本书可感受洛齐的艺术生活和洒脱风采,也可探寻书法主义的本质。
《一个书法主义者 洛齐》是10 卷本《书法主义文献丛书》中的一本,洛齐教授(中国美术学院)是这套丛书的主编。由于这套丛书是当代艺术研究的成果,具有很高的科学学术价值,它将在中华人民共和国的所有公共图书馆和大学分发,并将在全国范围内广泛传播。这套丛书是中国第一套关于书法文化和艺术领域获得中国国家图书最高学术奖的书,阿德丽亚娜·叶星(Adriana Iezzi)博士也是获得最高学术奖的作者。In this book, the author explores in detail the theory and practice of “Calligraphyism” (Shufazhuyi), the most important Chinese post-modern calligraphic movement, reconstructing its history and its diffusion in China and abroad. At the same time, the author deeply analyses the artistic production and theoretical thoughts of the founder of this movement, Prof. Luo Qi (Hangzhou, 1960). Prof. Luo Qi is one of the most important and influential calligraphers in contemporary China. In his works, calligraphy is used as a versatile art, receiving the mutual influence of Western art and "Modern Chinese Calligraphic Movement" (Zhongguo xiandai shufa), while in his theoretical writings, he thinks about the future of calligraphy, expanding the concept of Calligraphyism globally.
The book is divided into five chapters: 1. The Art of Calligraphy in Contemporary China; 2. Luo Qi's biography; 3. Luo Qi's works; 4. Calligraphyism; 5. Interviews about Luo Qi's art. A large number of images of calligraphic artworks and contemporary exhibitions enrich and expand the content of the book.
This book is included in a series of 10 books entitled “Calligraphyism. A Series of Books.” Prof. Luo Qi (China Academy of Art) is the editor of this series. Due to the high scientific value of this series, it will be distributed in all public libraries of the People's Republic of China and it will have a very wide diffusion throughout the Chinese territory. This series of books has been the first in China to win the highest academic award for Chinese National Books in the field of calligraphy, culture and art, and Dr. Adriana Iezzi has obtained this highest academic award as author of the book entitled “A Practitioner of Calligraphyism: Luo Qi”
Natural compounds, antioxidant, and antiandrogens in the prevention of prostate cancer: in vivo evidences from murine models and human clinical studies.
No full textProstate cancer (PCa)is the most frequent malignant neoplasia in men. The number of cases has continuously increased over the past decades, partly due to the higher life expectancy.
Additional factors are the high caloric diet and lack of physical exercise, typically seen in the Western countries. Notably, up to 40% of cancer incidents are preventable by consuming a
healthy diet, regular physical activity, and maintenance of optimum body weight, and more than 20% by consuming vegetables and fruits. PCa represents an ideal candidate disease for chemoprevention. It is typically diagnosed in elderly men and even a modest delay in the neoplastic development could result in substantial reduction in the incidence of the clinically detectable disease.In this chapter we will review the history, the development, and the applications of some of the most common animal models of PCa,and we will discuss of the role of animal models in translational research
《在中法之间 — 陈伟农的艺术体验》 Zai Zhong Fa zhi jian: Chen Weinong de yishu tijian / “Between China and France. The Artistic Experience of Chen Weinong”
No full textThe author analizes the artistic production of the Chinese contemporary artist Chen Weinong, who has travelled between China and France for more ten years. In his ink paintings and calligraphies, Chen Weinong reflects the essence of both Western and Eastern cultures, succeeding in refreshing the ancient tradition as well as blazing new trails in Chinese art
IN VITRO AND IN VIVO STUDIES FOR THE TREATMENT OF BASAL LIKE BREAST CANCER (BLBC) WITH AZOLATE/PHOSPHANE GOLD(I) COMPOUNDS
No full textIN VITRO AND IN VIVO STUDIES FOR THE TREATMENT OF BASAL LIKE BREAST CANCER (BLBC) WITH AZOLATE/PHOSPHANE GOLD(I) COMPOUNDS
Rossana Galassia, Alfredo Burinia, Oumarou Camille Simona, Anna Teresa Ramadoria, Stefania Pucciarelli,b Albana Hisy,c Manuela Iezzi,c Valentina Gambini b, Martina Tiliob, Cristina Marchini b, Augusto Amicib
a School of Science and Technology, Chemistry Division, Camerino University, Via Sant’ Agostino, I-62032 Italy.
b Department of Biosciences and Veterinary, University of Camerino, Via Gentile III da Varano, I-62032, Italy
c Aging Research Centre, G. d’Annunzio University, Chieti, 66100, Italy
e-mail: [email protected]
Breast cancer is a heterogeneous disease classified into molecular subtypes with distinctive gene expression signatures. Of all the molecular subtypes, BLBC has the worst negative outcome and prognosis. BLBCs are generally estrogen receptor (ER-) and progesterone receptor (PR)-negative and also lack high expression/amplification of HER2, limiting targeted therapeutic options. Thus, to date, Cisplatin remains the only possible therapeutic choice in the adjuvant or metastatic setting in the BLBC. Considering also several and serious side effects, new therapies are therefore an urgent unmet medical need for this patient population. Azolate gold(I) phosphane compounds have become good candidate for anticancer applications.[1] It was highlighted that azolate gold(I) phosphane compounds were mostly very active in the regards of many panel of cancer cells, in addition to cis-platin resistant cells. They show a mechanism of action involving the inhibition of seleno dependent ThioredoxinaReductase (TrxR), but they inhibit with IC50 in the micromolar scale also many other enzymes such as DeHydroFolateReductase.[1][2] In order to study the effectiveness of these new azolate gold(I) phosphane compounds as potential anticancer agents, different cell viability assays (MTT assays) were performed on a human in vitro model of HER2-overexpressing breast cancer: SKBR-3 cells.[3] After this preliminary screening, the most promising and effective compounds were selected to extend the study on A17 cell line, a murine preclinical model of Basal Like Breast Cancer (BLBC).[4] Hence, their efficacy in suppressing BLBC growth in vivo was tested and IHC analysis on explanted tumors were carried on. Overall, in vitro assays demonstrated a remarkable activity for those compounds having the Ph3PAu+ moiety and substituted imidazolate as co-ligands. Concerning the in vivo study the compounds act significantly delaying tumor growth. Accordingly, IHC analysis revealed a remarkable anti-angiogenic activity associated with a lower expression of proliferative markers and a higher level of apoptotic markers in treated tumours in comparison with controls. Moreover, respect to cisplatin these compounds displayed a lower nephrotoxicity, although their liver toxicity was higher. These promising results open the way to further investigations in order to understand the mechanism of action of these new azolate gold (I) posphane complexes.
References
[1] R. Galassi et al., Dalton Trans., 2012, (41), pp 5307-5318.
[2] R. Galassi et al., Dalton Trans., 2015, (44), pp 3043-3056.
[3] Fogh, J., Fogh J. M., Orfeo T, J Natl Cancer Inst. , 1977, (59), pp 221-6;
[4] M. Galiè et al., Carcinogenesis , 2005, (11), pp 1868-187
Discrimination of Different Human Cell Lines by Using FT-IR Spectra Spectroscopy
No full textFourier transform infrared (FT-IR) spectroscopy is a powerful analytical technique used to obtain molecular fingerprints of various biological samples. This study aims to compare the FT-IR spectra of three distinct cell lines, SH-SY5Y (neuroblastoma), HepG2 (hepatocellular carcinoma), and MCF-10A (epithelial mammary), to identify characteristic features in their spectra that can be used for this purpose. The FT-IR spectra revealed significant protein, lipid, and nucleic acid content variations among the cell lines. The differences mentioned above reflect each cell type’s unique biochemical environment and metabolic states. This distinction can help identify different cell lines. Understanding these spectral differences can provide insights into the molecular basis of cellular functions and aid in the development of cell-specific therapeutic strategies
Pathological changes of the anatomical structure and markers of the limbal stem cell niche due to inflammation.
Get PDFPURPOSE:
The corneoscleral limbus is the site of corneal epithelial stem cells (SC). The aim of this study is to evaluate the expression of different SC markers in the normal human limbus and to determine how this is affected by inflammation.
METHODS:
Corneoscleral specimens from healthy and inflamed donor eyes were examined by immunohistochemistry/immunofluorescence for p63, vimentin, laminin 5, integrin α6, β1, β4, ABCG2, desmoglein 3, connexin 43, N-cadherin, and cytokeratins 12 and 15. The distribution and anatomic structure of the limbal crypts and the percentage of SC marker antigens in healthy donors were analyzed. In inflamed tissues, we evaluated the anatomic structure of the limbal epithelial crypt (LEC) and the positivity for SC markers.
RESULTS:
In normal limbus, the niche structures were distributed differently. The variability of their number correlated with the percentage of p63 positivity. Integrin β1 staining directly correlated with p63 positivity while the remaining proteins were variably and widely distributed. Double staining for p63 and vimentin did not reveal any co-localization. In inflamed eyes, the basal cells in the crypts were "stretched" and surrounded by inflammatory cells, and only a few SC markers were still present.
CONCLUSIONS:
Diseases involving the limbus may result in marked changes of expression of SC markers within the LEC and also alter the crypt structure
WRITE. Chinese Calligraphy Between Artistic Contaminations and New Expressive-Communicative Languages. Dataset
No full textThe current dataset is associated with the Open Access publication “Chinese Calligraphy Between Artistic Contaminations and New Expressive-Communicative Languages: The Case of Wang Dongling’s Experimental Ink Movement” (Italian Association for Chinese Studies. Selected Papers 5, Venezia: Cafoscarina). It collects the metadata descriptions of the main artworks analysed in the publication as formalised in the “WRITE digital archive”, that is the semantic web digital archive of the WRITE project (G.A. 949645). Each jsonld file contains the metadata related to the artwork(s)/ itself/themselves, its author(s), its Calli-Writing Unit(s) (CWU – artwork content unit with calligraphic features), and, if any, related exhibition(s), and literary work(s).The artworks were selected from a large number of works included in the archive as the most representative of the ink calligraphic art by Wang Dongling. The dataset also includes the transcription of the artist’s interviews and the video cited in the publication
WRITE. Calligraphy and Performance Art in Contemporary China. Dataset
No full textThe current dataset is associated with the Open Access publication “Calligraphy and Performance Art in Contemporary China from Blackened Writing to Gender Identity” (Italian Association for Chinese Studies. Selected Papers 5, Venezia: Cafoscarina). It collects the metadata descriptions of the main artworks/series analysed in the publication as formalised in the “WRITE digital archive”, that is the semantic web digital archive of the WRITE project (G.A. 949645). Each jsonld file contains the metadata related to the artwork(s)/series itself/themselves, its author(s), its Calli-Writing Unit(s) (CWU – artwork content unit with calligraphic features), and, if any, related exhibition(s), artwork(s), and literary work(s).The artworks/series were selected from a large number of works included in the archive as the most representative of the new forms of calligraphy emerged in the context of performance art. The dataset also includes the transcription of the two artists’ interviews cited in the publication
WRITE. Performance of Genders. Dataset
No full textThe current dataset is associated with the Open Access publication “Performance of Genders: Marking Masculine/Feminine Identities through Body and Calligraphy”, MediAzioni, 2025, 46. It collects the metadata descriptions of the main artworks/series analysed in the publication as formalised in the “WRITE digital archive”, that is the semantic web digital archive of the WRITE project (G.A. 949645). Each jsonld file contains the metadata related to the artwork(s)/series itself/themselves, its author(s), its Calli-Writing Unit(s) (CWU – artwork content unit with calligraphic features), and, if any, related exhibition(s), artwork(s), and literary work(s).The artworks/series were selected from a large number of works included in the archive as the most representative of different approaches/perspectives on gender issues in Chinese performance art. The dataset also includes the transcription of the two artists’ interviews cited in the publication. The data, here provided in a machine-readable format, are already described in a discursive way in the related publication
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