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Diagnostic approach of patients with possible viral myocarditis
Full text linkΗ μυοκαρδίτιδα παραμένει ακόμα και στην σημερινή εποχή μία νόσος που εμφανίζεται συχνά σε άτομα νεαρής και μέσης ηλικίας αλλά δυστυχώς η διάγνωση της επιβεβαιώνεται αρκετά δύσκολα. Η διάγνωση της ιογενούς μυοκαρδίτιδας αποτελεί πρόκληση καθώς τα διαγνωστικά μέσα που χρησιμοποιούνταν μέχρι πρόσφατα στερούνταν υψηλής ευαισθησίας και ειδικότητας. Η ορθή λήψη ιστορικού, η λεπτομερής κλινική εξέταση, οι αιματολογικές και ορολογικές εξετάσεις, το ηλεκτροκαρδιογράφημα και οι απεικονιστικές εξετάσεις συμπεριλαμβανομένων του υπερηχοκαρδιογραφήματος και της μαγνητικής τομογραφίας καρδιάς συνέβαλαν έως τώρα στην διαγνωστική προσπέλαση των ασθενών με πιθανή μυοκαρδίτιδα. Όμως η εισαγωγή νέων ανοσοϊστοχημικών και μοριακών τεχνικών στην διαγνωστική προσπέλαση των ασθενών με πιθανή μυοκαρδίτιδα βοηθά σημαντικά όχι μόνο στην ακριβή διάγνωση αλλά και στο καθορισμό θεραπευτικού πλάνου με βάση την ακριβή αιτιολογία της μυοκαρδίτιδας. Παρόλα αυτά η διενέργεια ενδομυοκαρδιακής βιοψίας και η εφαρμογή των παραπάνω τεχνικών απαιτούν υψηλό βαθμό εξειδίκευσης και εμπειρίας. Επίσης σημαντικά ερωτήματα παραμένουν ιδίως σχετικά με το ποιοι ασθενείς και σε ποιο βαθμό ωφελούνται από την ανοσοκατασταλτική θεραπεία. Περισσότερη έρευνα χρειάζεται επίσης στο πεδίο της στοχευμένης θεραπείας της ιογενούς μυοκαρδίτιδας. Είναι φανερό ότι προκειμένου να επιτευχθεί αποτελεσματική θεραπεία των περιπτώσεων μυοκαρδίτιδας, θα πρέπει η ιατρική επιστήμη να αναλύσει και να κατανοήσει πλήρως τις παθοφυσιολογικές οδούς που ενεργοποιούνται κατά την διαδρομή μιας μυοκαρδίτιδας.Even today, myocarditis remains a disease that often occurs in young and middle-aged people, but unfortunately its diagnosis is difficult to confirm. Diagnosis of viral myocarditis is a challenge as the diagnostic tools used until recently lacked high sensitivity and specialty. Proper history, detailed clinical examination, hematological and serological examinations, electrocardiogram and imaging tests including echocardiogram and cardiac magnetic resonance have so far helped to diagnose patients with potential myocarditis. Nevertheless, the introduction of new immunohistological and molecular techniques in the diagnostic approach of patients with possible myocarditis helps significantly not only in the precise diagnosis but also in the setting of a treatment plan based on the exact etiology of myocarditis. However, endomyocardial biopsy and the application of the above techniques require a high degree of specialization and experience. Important questions remain, in particular, about which patients and to what extent will be benefit from immunosuppressive therapy. Also, more research is needed in the field of targeted treatment of viral myocarditis. It is clear that in order to achieve effective treatment of myocarditis, medical science needs to fully analyze and understand the pathophysiological pathways activated in the course of a myocarditis
Diagnostic approach of patients with possible viral myocarditis
No full textABSTRACT
Even today, myocarditis remains a disease that often occurs in young and middle-aged people, but unfortunately its diagnosis is difficult to confirm. Diagnosis of viral myocarditis is a challenge as the diagnostic tools used until recently lacked high sensitivity and specialty. Proper history, detailed clinical examination, hematological and serological examinations, electrocardiogram and imaging tests including echocardiogram and cardiac magnetic resonance have so far helped to diagnose patients with potential myocarditis. Nevertheless, the introduction of new immunohistological and molecular techniques in the diagnostic approach of patients with possible myocarditis helps significantly not only in the precise diagnosis but also in the setting of a treatment plan based on the exact etiology of myocarditis. However, endomyocardial biopsy and the application of the above techniques require a high degree of specialization and experience. Important questions remain, in particular, about which patients and to what extent will be benefit from immunosuppressive therapy. Also, more research is needed in the field of targeted treatment of viral myocarditis. It is clear that in order to achieve effective treatment of myocarditis, medical science needs to fully analyze and understand the pathophysiological pathways activated in the course of a myocarditis
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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