132 research outputs found
Recognition without identification (RWI) and the feeling of knowing (FOK): a comparison of retrospective and prospective-based familiarity judgments
No full text2010 Summer.Includes bibliographic references (pages 51-54).Covers not scanned.Print version deaccessioned 2022.Recognition without identification (RWI) and the feeling of knowing (FOK) are two memory paradigms that attempt to tap awareness of memory states in the absence of identification of a target. Although both RWI and FOKs have been described using the example of recognizing a face as familiar without recalling who that person is, no empirical evidence has yet demonstrated that they are based on a common underlying mechanism. The presented studies attempted to directly compare RWI and FOK judgments by utilizing a hybrid paradigm containing commonly used RWI and FOK methodologies that differed by a single manipulation of instruction type. The data demonstrated that participants gave significantly different patterns of ratings in the RWI condition than the FOK condition, suggesting different underlying mechanisms of RWI and FOK judgments
Liang zi dian zai jin shu na mi jie gou shang de ying guang dong tai
No full textFok, Chi Ho = 量子點在金屬納米結構上的熒光動態 / 霍智灝.Thesis M.Phil. Chinese University of Hong Kong 2013.Includes bibliographical references (leaves 136-147).Abstracts also in Chinese.Title from PDF title page (viewed on 03, November, 2016).Fok, Chi Ho = Liang zi dian zai jin shu na mi jie gou shang de ying guang dong tai / Huo Zhihao
Continuous microdialysis of blood proteins during cardiopulmonary bypass:
No full textCardiopulmonary bypass is a procedure that temporarily substitutes a patients’ heart and lung functions with an extracorporeal heart-lung machine. This allows surgeons to operate on motionless heart and lungs, while still providing the body with proper blood circulation. However, the heart-lung machine has been shown to activate the body’s systemic inflammatory response, resulting in short- and long- term organ dysfunction, and even death. The severity of this inflammatory response is strongly correlated to the production levels of specific cytokines and complements found in the bloodstream. Current detection methods require taking discrete blood samples during surgery and waiting at least several hours, but typically one to two weeks when including laboratory queue times in hospitals, for results. I propose a microdialysis device that continuously samples the patient’s blood for biomarkers during surgery. The primary function of this device is to prepare a purified solution, with complement concentrations that closely matches that of the patient’s bloodstream, to be used in a continuous microimmunoassay device.
The microdialysis device was fabricated using photolithography and softlithography techniques to create microfluidic channels and bonded to commercially available semi-permeable membranes with biocompatible epoxy. The device was designed based on computational simulations and fabrication constraints for optimal performance. It was tested for its analyte-recovery capabilities for complements C3a, C4a, and C5a, in human blood continually circulating through a mock heart-lung machine.
Two slightly different designs were tested, one using a membrane pore-diameter of 0.1 µm and the other using 0.4 µm. Both devices operated at a perfusion flowrate of 4.1 µL/min, which is considered to be relatively fast for microdialysis probes. For the 0.1 µm pore membrane device, the relative recoveries were 79%, 75%, and 70% for C3a, C4a, and C5a, respectively. For the 0.4 µm pore membrane device, the relative recoveries were 112%, 135%, and 101% for C3a, C4a, and C5a, respectively. These findings show promising results for the proposed microdialysis device, but further investigation is needed to improve statistical significance.M.S.Includes bibliographical references (p. 89-94)by Alexander Fo
Differences in profiles of emotional behavioral problems across instruments in verbally fluent versus language impaired children with Autism Spectrum Disorder
No full textThere has been increasing attention to the assessment of minimally verbal (MV) children with Autism spectrum disorder (ASD). Previous research has begun to examine the relationship between verbal abilities and emotional and behavioral problems (EBP). The current study compared parent-reported EBP in children of differing language levels on two instruments commonly used in ASD research and clinical practice, the Child Behavior Checklist (CBCL) and Aberrant Behavior Checklist (ABC). The study consisted of 1,937 6-18 years old children with ASD from the Simons Simplex Collection. Children were divided into three language groups, by ADOS module (Module 1 = MV, 2 = phrase speech (PS), 3 and 4 = verbally fluent (VF)) and then compared on CBCL and ABC subscales. The ABC and CBCL showed different patterns of elevations across the language groups. MV children were reported to have more impairment than VF children on the ABC Irritability, Lethargy and Hyperactivity scales. Children with less language (MV and PS) exhibited less impairment on the CBCL Internalizing domain than VF children, but did not differ on the Externalizing domain. Post hoc comparisons showed that Internalizing differences were driven by fewer children with less language exhibiting clinically elevated Anxious/Depressed scores compared to VF children. The present study underscores the significance of considering language when assessing EBP. Results have implications for the psychiatric screening of children with ASD, particularly those with language impairments. Researchers should exercise caution when applying EBP instruments designed for use with different populations and purposes to broad samples of children.Peer reviewe
Demographics, family/social interaction, and household finance
No full textWe examine the role of demographics and family/social interaction in Chinese household finance. The impacts of demographic characteristics are not limited to stock market participation, but extend to other financial activities. Households with strong family and social interaction are more likely to save, invest in risky assets and borrow. Family interaction is positively related to informal financing
Hedging costs, liquidity, and inventory management: The evidence from option market makers
No full textHedging the risk of holding undesired inventory is very important for market makers. However, prior studies seldom capture the role of inventory positions in measuring hedging costs. This study measures hedging costs directly using data on inventory positions of market makers in the Taiwan Index Options market. We break down rebalancing costs into two sources: rebalancing costs due to inventory changes and rebalancing costs due to delta changes. Contrary to prior studies on stock options, we find rebalancing costs are more important than initial hedging costs in explaining option spreads. Our findings underscore the importance of inventory management. (C) 2013 Elsevier B.V. All rights reserved.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000333376600002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Business, [email protected]; [email protected]; [email protected]; [email protected]
Autism spectrum disorder symptoms from 2 to 19: implications for diagnosing adolescents and young adults
No full textThis study explored change in social-communicative symptoms in 140 individuals with childhood Autism Spectrum Disorder (ASD) diagnoses. Trajectories of caregiver-reported social-communicative symptoms were examined for three groups (verbal, delayed speech, minimally verbal) from ages 2 to 19 years. Groups showed comparable levels of social-communicative impairment at 2 and significant decreases in overall symptom levels across the 17-year period (p<.001). Across three subdomains, main effects of time and language (p<.001) reflected patterns of overall improvement, though children with more impaired language tended to have more caregiver-reported symptoms relative to verbal peers. A significant time-by-language interaction (p<.001) reflected that trajectories of socioemotional reciprocity symptoms differed according to patterns of language development. In contrast, improvements in the nonverbal communication domain were seen across language groups, whereas deficits in the development and maintenance of relationships improved for only verbal children. Verbal adults showed significant reductions in the prevalence of several symptoms exhibited during childhood. Improvements suggest that symptoms indicative of ASD in young children may no longer be diagnostic markers in adolescents and adults. Relative stability of several items suggests that impaired facial expression may be a core ASD symptom that warrants more systematic study across the lifespan. Research investigating the manifestation of ASD in older individuals is needed to foster development of appropriate assessment tools and interventions. Differential relationships to developmental factors within the broader social-communication domain underscores a need to focus on more narrowly defined symptom constructs when exploring links between pathophysiology and observable phenotypes.Peer reviewe
Overcoming tumor drug resistance with high-affinity taxanes: A SAR study of C2-modified 7-acyl-10-deacetyl cephalomannines
No full textA series of C2-modified 10-deacetyl-7-propionyl cephalomannine derivatives was designed, prepared, and biologically evaluated. Some C2 meta-substituted benzoate analogues showed potent activity against both drug-sensitive and drug-resistant tumor cells in which resistance is mediated through either P-gp overexpression or b-tubulin mutation mechanisms. The taxoid 15b and related compounds are of particular interest, as they are much more cytotoxic than paclitaxel, especially against drug-resistant tumor cells; they are able to kill both drug-resistant and drug-sensitive cells (low R/S ratio), and they have high affinity for β-tubulin. Our research results led to an important hypothesis, that is, a taxane with very high binding affinity for β-tubulin is able to counteract drug resistance, which may assist in future taxane-based drug-discovery efforts.The authors thank the Foundation for the Author of National Excellent Doctoral Dissertation of P. R. China (Grant No. 199949), the Fok Ying Tong Education Foundation (Grant No. 91037), and the National Natural Science Foundation (Grant No. 20572135) (to W.-S.F.); the Dirección General de Investigación Científica y Tecnológica (DGICYT, Grant BFU2004-00358), the Comunidad Autonoma de Madrid (Grants CAM200520M061 and BIPPED-CM), the Ministerio de Educación y Ciencia of Spain (Grant BFU-2004-0038) (to J.F.D.); and the Canadian Cancer Society (to F.J.S.) for financial support
Out of sight, not out of mind: The evidence from Taiwan mutual funds
No full textThis paper extends the current literatures on the relation between fund expenses and fund flows using data from Taiwan. Our findings for the Taiwan market differ from previous studies on the U.S. market. Specifically, we find no support for the notion of "out of sight, out of mind". For Taiwan mutual funds, net flows and inflows are negatively related to operating expenses but not front-end loads. The discrepancy between our results and those reported for the U.S. market may be attributed to the fee structure in Taiwan, where operating expenses are much higher than front-end loads and seem to have a bigger impact on fund performance. The negative relation between net flows (inflows) and operating expenses is more pronounced for funds with high institutional investor participation and funds charging high operating expenses. However, investor types show no significant impact on the relations between front-end loads and various measures of fund flows. (C) 2014 Elsevier Inc. All rights reserved.National Science Council of Taiwan [NSC 100-2410-H-130-024][email protected]; [email protected]; [email protected]; [email protected]
Foveated Stereo Video Compression for Visual Telepresence
No full textI hereby declare that I am the sole author of this thesis. This is a true copy of the thesis, including any required final revisions, as accepted by my examiners. I understand that my thesis may be made electronically available to the public. ii This thesis focuses on the design of a foveated stereo video compression algorithm for visual telepresence applications. In a typical telepresence application, a user at the local site views real-time stereo video recorded and transmitted from a robotic camera platform located at a remote site. The robotic camera platform tracks the user’s head motion pro-ducing the sensation of being present at the remote site. The design of the stereo video compression algorithm revolved around a fast spatio-temporal block-based motion estimation algorithm, with a foveated SPIHT algorithm used to compress and foveate the independent frames and error residues. Also, the redundancy between the left and right video streams was exploited by disparity compensation. Finally, position feedback from the robotic camera platform was used to perform global motio
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