106,541 research outputs found
Panoramic overview of unconventional approaches to detect chiral information
No full textThe concept of inherent chirality has gained considerable attention due to the possible synthesis of π-conjugated monomers that can be employed for preparing chiral electrode surfaces after electrooligomerization [1]. These materials have been used in enantiorecognition measurements involving chiral analytes, resulting in high selectivity based on diastereomeric interactions between the deposited enantiopure antipode and the probes dissolved in solution. In this context the high enantioselectivity of such chiral surfaces was used in combination with the mechanical and electrical properties of polypyrrole (Ppy) films to develop three new straightforward read-outs for the absolute on-off recognition of enantiomers of a chiral probe in solution; i) electromechanical deformation (a) [2], ii) electrochemically induced light emission (b) [3] and iii) self-induced enantioselective trajectories (c) [4]. These new approaches allow to convert chiral information present at the molecular level into macroscopic actuation, light emission or controlled trajectories. Furthermore, such systems allow correlating the output signal with the concentration of the enantiomers present in solution, even in the case of mixtures containing different ratios of the molecular antipodes.
[1] Arnaboldi, S.; Benincori, T.; Cirilli, R.; Kutner, W.; Magni, M.; Mussini, P. R.; Noworyta, K.; Sannicolo,̀ F. Chem. Sci. 2015, 6, 1706− 1711.
[2] Arnaboldi, S.; Gupta, B.; Benincori, T.; Bonetti, G.; Cirilli, R.; Kuhn, A. Anal. Chem. 2020, 92, 10042−10047.
[3] Salinas, G.; Arnaboldi, S.; Bonetti, G.; Cirilli, R.; Benincori, T.; Kuhn, A. Chirality 2021, 33, 875-882.
[4] Arnaboldi, S.; Salinas, G.; Karajic, A.; Garrigue, P.; Benincori, T.; Cirilli, R.; Bichon, S.; Gounel, S.; Mano, N.; Kuhn, A. Nat. Chem. 2021, 13, 1241-1247.
Keywords: (inherent)chirality; bipolar electrochemistry, chiral actuator, chiral swimmers, light emitting diodes
This work has been funded by the European Research Council (ERC) under the HORIZON-ERC-2021 program (grant agreement no 101040798, ERC Starting Grant CHEIR)
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Unconventional Electrochemical Approaches for the Direct Readout of Chiral Information
No full textAmong the different strategies to endow conducting polymers with chiral features, the concept of inherent chirality is extremely attractive and efficient for several reasons. [1] Inherent chirality is an intrinsic propriety of the whole molecule in which the stereogenic element responsible for chirality coincides with the functional group responsible for the specific properties of the molecular material. The racemization barrier of these molecules is high enough to allow the separation into stable enantiomers by chiral HPLC. Their electro-oligomerization results in chiral electrode surfaces able to discriminate the antipodes of chiral species by differences in peak potential recorded by voltammetry. [2] This is a true advantage from an analytical point of view, because it is possible to achieve the enantioselective discrimination in racemic mixtures of the analyte, in contrast to most of the approaches presented in literature for which the recognition is only based on differences in current intensity. In this context the high enantioselectivity of such chiral surfaces was used to develop i) a new approach based on bipolar electrochemistry for the absolute on-off recognition of enantiomers of a chiral probe, [3] and ii) new autonomous enzymes based swimmers able to convert chiral information present at the molecular level into macroscopic enantioselective trajectories. [4]
[1] Arnaboldi, S.; Magni, M.; Mussini, P. R. Curr. Opin. Electrochem. 2018, 8, 60−72.
[2] Arnaboldi, S.; Benincori, T.; Cirilli, R.; Kutner, W.; Magni, M.; Mussini, P. R.; Noworyta, K.; Sannicolo,̀ F. Chem. Sci. 2015, 6, 1706− 1711.
[3] Arnaboldi, S.; Gupta, B.; Benincori, T.; Bonetti, G.; Cirilli, R.; Kuhn, A. Anal. Chem. 2020, 92, 10042−10047.
[4] Arnaboldi, S.; Salinas, G.; Karajic, A.; Garrigue, P.; Benincori, T.; Cirilli, R.; Bichon, S.; Gounel, S.; Mano, N.; Kuhn, A. Nat. Chem. 2021, in pres
Le infezioni della mano in ambito lavorativo
No full textLe infezioni della mano, nonostante il notevole decremento della loro incidenza grazie al maggiore uso di protezioni nell’ambiente di lavoro e a una corretta educazione professionale, rimangono un problema di grande attualità. Se la terapia medica ha recentemente guadagnato nuovi, rivoluzionari e potenti mezzi di cura, la terapia chirurgica non ha in alcun modo perso la sua validità ed insostituibilità: pertanto le moderne strategie terapeutiche si fondano su un tempestivo ed integrato approccio medico e chirurgico.
Da una approfondita analisi della letteratura corrente e dall’esperienza maturata in Centri Ospedalieri di grande tradizione, italiani e stranieri, gli Autori hanno elaborato una comprensiva trattazione delle infezioni della mano in ambito lavorativo, con una presentazione di agenti eziologici, quadri anatomopatologici e clinici in relazione ai presidi terapeutici, medici e chirurgici, più appropriat
Spalvos prasmingumas T. Mano novelėje ,,Mirtis Venecijoje"
No full textFarbenakzente in der Novelle sind mit der Innensicht und Außensicht des Erzählers verbunden.
Am häufigsten erscheint die Farbe dort, wo man Absicht hat, die innere Dynamik und Veränderungen der Stimmungen und Zustände des Haupthelden zu enthüllen. Die Intensität der Farben erscheint im Rahmen der gegenwärtigen Zeit, unterstreicht das verstärkte Interesse Aschenbachs für das Leben und die Schönheit. Dagegen, was die literarische Aschenbachs Lebensbahn, seine Vergangenheit und seine Erwägungen anbetrifft, verwendet Th. Mann fast keine Farben.
In der Novelle „Tod in Venedig" bewahrt der Autor die direkte Verbindung des Farbenattributs mit den Gegenständen. Der psychologische Farbensinn wird in der Novelle leicht erfassbar. Der Schriftsteller hält sich an die traditionelle europäische Symbolik: schwarz - der Tod, der Kummer; rot - die Liebe, golden - die Schönheit, Erhabenheit usw.
Geneigt zu den symbolischen Verallgemeinerungen, misst Th. Mann auch in anderen seinen Werken der Farbe eine symbolische Deutung bei. So zum Beispiel verkörpert rot in Th. Manns Novellistik die Sphäre „des Lebens", schwarz - die Ahnung des Todes („Tristan", „Die Betrogene" u. a. m.).
Die Analyse der Farbenakzente des Textes hilft, die Zwiespältigkeit der seelischen Erneuerung Aschenbachs präzisieren.
Es offenbart sich auch der versteckte Lyrismus der Novelle, ihre Poesie, das sind die Eigenschaften, deren die meisten Forscher seines Schaffens nicht gewahr sind.
Die Frage des Einflusses der bildenden Kunst auf sein Schaffen ist nicht eindeutig. Es lässt sich ein indirekter Einfluss von verschiedenen Kunstströmungen Ende des 19. Anfang des 20. Jahrhunderts (Jugendstil, Impressionismus) auf seine schöpferische Impulse ersehen.Spalviniai akcentai novelėje yra susiję su vidiniu ir išoriniu pasakotojo požiūriu (Erzählperspektive).Dažniausiai spalva atsiranda ten, kur norima atskleisti pagrindinio herojaus, rašytojo Ašenbacho, vidinio gyvenimo dinamiką, jo nuotaikų, būsenų kaitą. Spalvinis intensyvumas išryškėja dabartinio laiko ribose, pažymi sustiprėjusį Ašenbacho susidomėjimą gyvenimu, grožiu. Literatūrinei Ašenbacho biografijai, jo praeičiai, apmąstymams pavaizduoti T. Manas spalvos beveik nenaudoja.
Novelėje „Mirtis Venecijoje" autorius išsaugo tiesioginį spalvinio pažyminio ryšį su daiktais. Psichologinė spalvos prasmė novelėje gana lengvai suvokiama. Rašytojas laikosi būdingos europietiškai tradicijai simbolikos tipo: juoda - mirtis, sielvartas; raudona - meilė; auksinė - grožis, didingumas ir t. t.
Linkęs, kaip žinia, į simbolinius apibendrinimus, T. Manas ir kituose savo kūriniuose spalvai suteikia simbolinę prasmę. Pvz., raudona dažniausiai Mano novelistikoje įkūnija „gyvenimo" sferą, juoda - mirties nuojautą („Tristanas", „Apgautoji" ir kt.).
Teksto spalvinių akcentų analizė padeda patikslinti Ašenbacho dvasinio atgimimo dvylipumą, jausmų prieštaringumą.Išryškėja taip pat ir paslėptas novelės lyriškumas, poetiškumas, savybės, kurių dažniausiai T. Mano kūrybos tyrinėtojai nepastebi.
Tapybos poveikio T. Mano kūrybai klausimas lieka atviras. Galima įžvelgti netiesioginę įvairių XIX a. pabaigos-XX a. pradžios meno srovių įtaką T. Manui kūrybinių impulsų plotmėje (turima omeny Jugendstil, impresionizmas)
Más vale pájaro en mano: crisis bancaria, ahorro y clases medias de María Pía Vera T.
No full textReview of Más vale pájaro en mano: crisis bancaria, ahorro y clases mediasby María Pía Vera T.Reseña de Más vale pájaro en mano: crisis bancaria, ahorro y clases medias de María Pía Vera T
T-NOVA: An open-source MANO stack for NFV infrastructures
No full textOne of the primary challenges associated with network functions virtualization (NFV) is the automated management of the service lifecycle. In this paper, we present a full software-based management and orchestration (MANO) stack which operates with OpenStack and OpenDaylight controllers and has the in-built functionality to automate the key phases of the NFV service lifecycle, namely resource discovery and matching, service mapping, service deployment, and monitoring. The MANO stack is being implemented by the EU FP7 project T-NOVA, with the components being released as open-source software. Service mapping and service deployment solutions developed in the scope of T-NOVA are presented in detail. As a proof-of-concept, we evaluate the performance of a virtualized traffic classifier network function, demonstrating the gains of virtualized hardware acceleration. © 2017 IEEE
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
La coyuntura de la mano de obra espanola en Europa en 1965
No full textT. G. La coyuntura de la mano de obra espanola en Europa en 1965. In: Population, 22ᵉ année, n°1, 1967. p. 147
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