1,721,141 research outputs found
Monoclonal Antibodies and Flaviviruses: a Possible Option?
Full text linkM. P. Doyle, J. R. Genualdi, A. L. Bailey, N. Kose, et al. (mBio 13:e00512-22, 2022, https://doi.org/10.1128/mBio.00512-22), report on the cloning of a panel of fully human monoclonal antibodies (mAbs) directed against yellow fever virus (YFV). In particular, mAb YFV-136 is endowed with interesting cross-YFV substrain-neutralizing features. The importance of YFV-136 and other mAbs with similar characteristics is related not necessarily only to their possible future use in the clinic but also to their role in a better understanding of the biology of YFV (as well as of other flaviviruses) for the development of effective therapeutic and prophylactic strategies. The emergence and reemergence of different flaviviruses worldwide in the last decades certainly make this a compelling clinical priority
Percorsi di territorializzazione di spazi pubblici interstiziali a Firenze
Full text linkLa tesi illustra un'indagine che si propone di individuare e analizzare alcuni fenomeni alla base di percorsi di territorializzazione di spazi pubblici interstiziali a Firenze. L'obiettivo è quello di realizzare attraverso lo studio di casi reali un quadro conoscitivo utile ad orientare le scelte di pianificazione urbanistica e di gestione del territorio urbano.
La scelta di approfondire questo specifico tema di ricerca è emersa osservando l'esistenza di spazi urbani che all'origine non sono stati pianificati per essere spazi pubblici convenzionali ad esempio come piazze o parchi, ma nei quali si realizzano dei percorsi di territorializzazione che rappresentano risposte spontanee alla domanda di spazio pubblico.
Si è osservato che la letteratura sull'argomento, nei vari ambiti disciplinari che si occupano dello studio della città , tende a concentrarsi nella descrizione e nell'analisi dello spazio pubblico partendo dalle caratteristiche funzionali e/o morfologiche dei luoghi. Al contrario, sono più rari e non sufficientemente sistematici gli esempi che partono dai modi d'uso dello spazio attraverso i quali invece è possibile evidenziare ulteriori spazi pubblici altrettanto rilevanti.
Lo studio di casi del genere può gettare luce su importanti fenomeni di territorializzazione da parte di attori diversi, con ricadute significative sia sul piano teorico, sia applicativo. Si rischia infatti di trascurare fenomeni evidenti di appropriazione territoriale finendo con l'invalidare fortemente lo spettro delle ipotesi progettuali e delle scelte operate sul territorio da parte delle figure deputate.
Sul piano metodologico si è ritenuto ricorrere ad una combinazione di strumenti qualitativi (interviste semi-strutturate sul campo) e quantitativi (rilevazione diretta sul campo, osservazione).This thesis describes an investigation that aims to identify and analyze some phenomena underlying pathways of territorial public spaces interstitial to Florence. The objective is to achieve through the study of real cases a useful cognitive framework to guide both the choices of urban planning and the management of urban territories.
The decision to pursue this specific research topic emerged noting the existence of urban spaces that were not originally scheduled to be conventional public spaces such as squares or parks, but urban areas where the spontanous response to the demand of public spaces is represented by the creation (growth) of terrotorial paths.
It was noted that the literature that faces this subject in various disciplines, that are involved in the study of the city, tends to concentrate its focus on the description and analysis of public space starting from the functional and / or morphological sites. On the contrary, are more rare and not sufficiently systematic examples that start from the ways of use of space through which ones it is possible to highlight further public spaces equally relevant.
The study of such cases can shed light on important phenomena of regionalization made by different actors that proove a significant impact both on a theoretical and on an applicative level.
The risk,infact, is to neglect clear phenomena of territorial ownership perhaps strongly voiding the spectrum of the territorial planning hypothesis and choices Made by the deputies figures.
On a methodological level, it has been considered to use a combination of qualitative(semi-structured interviews on-the-spot) and quantitative instruments (direct detection on-the-spot, observation)
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Reaction times and movement times. Difference between black belt vs. novice teakwondo athletes.
No full textPhysical education in primary school. Study on motor performances, physical self-efficacy and Body Mass Index for monitoring interventions.
No full text
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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