63,530 research outputs found
Erratum to: Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with Type 2 diabetes mellitus (Diabetic Medicine, (2006), 23, 9, (974-981), 10.1111/j.1464-5491.2006.01886.x)
No full textIn an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola.In an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola
SYNBIOCHEM Synthetic Biology Research Centre, Manchester - A UK foundry for fine and speciality chemicals production
No full textThe UK Synthetic Biology Research Centre, SYNBIOCHEM, hosted by the Manchester Institute of Biotechnology at the University of Manchester is delivering innovative technology platforms to facilitate the predictable engineering of microbial bio-factories for fine and speciality chemicals production. We provide an overview of our foundry activities that are being applied to grand challenge projects to deliver innovation in bio-based chemicals production for industrial biotechnology
External evaluation of the Manchester score in a contemporary SCLC cohort
No full textOBJECTIVES: The Manchester Score, a prognostic model developed in 1987, was used to stratify patients with Small Cell Lung Cancer (SCLC) by mortality risk, including stage, performance status, and three blood tests as risk factors. Many tools have since been developed for this purpose, but few have seen clinical use, with lack of robust external validation frequently cited as a barrier. In this study we apply a robust and pragmatic external validation approach to the Manchester Score to understand if it remains valid in an unselected modern patient cohort.METHODS: SCLC patients treated in an academic centre between 2013 and 2022 (N = 1783) were included in the validation cohort. Discrimination was assessed using Kaplan-Meier curves, AUC, and Harrell's C-index for the Manchester score and its underlying Cox model. Three levels of Cox model updating were used to address missing baseline hazard data: recalibration, recalibration with rescaling, and model refitting. Calibration was then evaluated with optimism adjustment at 6-, 12-, and 24-months post-diagnosis.RESULTS: The Manchester score shows good discrimination in the modern patient cohort. There is clear separation between risk groups in the Kaplan-Meier curves, with AUC = 0.75 and C-index = 0.68 for the Manchester Score and (AUC = 0.79, C-index = 0.70) for the underlying Cox model. Median survival in the 'good' prognostic group (meeting < 2/5 risk criteria) has increased compared to that from 1987. All model updating methods reported good calibration, with recalibration alone providing the best observed-to-expected ratio at 6 months (1.012 [0.978,1.045]).CONCLUSION: The original Manchester Score prognostic groups remain discriminative of survival, and when updated can predict survival probability at multiple timepoints.</p
TEMPO2: a new pulsar timing package - III. Gravitational wave simulation
No full textG. Hobbs, F. Jenet, K. J. Lee, J. P. W. Verbiest, D. Yardley, R. Manchester, A. Lommen, W. Coles, R. Edwards and C. Shettigar
Economics of the football club Mancherster United F. C.
No full textHlavním cílem této bakalářské práce je zhodnocení ekonomiky fotbalového klubu Manchester United F. C. a její porovnání s konkurenčními kluby za období 2009-2013. Dílčím cílem je vyhodnocení splnitelnosti nových pravidel UEFA Financial Fair Play. V teoreticko-metodologické části jsou uvedeny specifické charakteristiky ekonomiky sportovních klubů. Dále je popsán obsah nových pravidel UEFA Financial Fair Play. Následuje popis metod a ukazatelů finanční a ekonomické analýzy. Praktická část se zaměřuje na analýzu ekonomiky vybraného fotbalového klubu Manchester United F. C.The main aim of this Bachelor's thesis is to assess economic situation of the football club Manchester United F. C. and to compare it with competing clubs in the period from 2009 to 2013. The partial aim is to assess fulfilment of the new UEFA Financial Fair Play Regulations. The theoretical part states specific characteristics of the economics of sports clubs. Furthermore, it describes the content of the UEFA Financial Fair Play Regulations. It is followed by description of the methods and indicators of financial and economic analysis. The practical part is focused on analysis of economic situation of the football club Manchester United F. C
Text-fig. 8. Pterocaryoxylon sp., a–c, e: UF 279-85024; d, f: UF 279-24551. a, b: Wood semi-ring-porous, vessels solitary and in short radial multiples, axial parenchyma scanty vasicentric, marginal, and in narrow lines, TS. c: Crowded alternate intervessel pitting, simple perforation plate (PP), TLS. d: Vessel-axial parenchyma pitting similar to intervessel pitting, RLS. e: Rays mostly 1–3 cells wide, occasionally 4 cells, uniseriate rays probably mostly square to upright cells, TLS. f: Rays heterocellular, body cells procumbent. Scale bars: 200 µm in a, b; 100 µm in e, f; 50 µm in c; 20 µm in d. in A Diverse Assemblage Of Late Eocene Woods From Oregon, Western Usa
No full textText-fig. 8. Pterocaryoxylon sp., a–c, e: UF 279-85024; d, f: UF 279-24551. a, b: Wood semi-ring-porous, vessels solitary and in short radial multiples, axial parenchyma scanty vasicentric, marginal, and in narrow lines, TS. c: Crowded alternate intervessel pitting, simple perforation plate (PP), TLS. d: Vessel-axial parenchyma pitting similar to intervessel pitting, RLS. e: Rays mostly 1–3 cells wide, occasionally 4 cells, uniseriate rays probably mostly square to upright cells, TLS. f: Rays heterocellular, body cells procumbent. Scale bars: 200 µm in a, b; 100 µm in e, f; 50 µm in c; 20 µm in d.Published as part of Wheeler, Elisabeth A. & Manchester, Steven R., 2021, A Diverse Assemblage Of Late Eocene Woods From Oregon, Western Usa, pp. 299-329 in Fossil Imprint 77 (2) on page 315, DOI: 10.37520/fi.2021.022, http://zenodo.org/record/716758
Economics of the football club Mancherster United F. C.
No full textThe main aim of this Bachelor's thesis is to assess economic situation of the football club Manchester United F. C. and to compare it with competing clubs in the period from 2009 to 2013. The partial aim is to assess fulfilment of the new UEFA Financial Fair Play Regulations. The theoretical part states specific characteristics of the economics of sports clubs. Furthermore, it describes the content of the UEFA Financial Fair Play Regulations. It is followed by description of the methods and indicators of financial and economic analysis. The practical part is focused on analysis of economic situation of the football club Manchester United F. C
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Text-fig. 6. Quercus sp. Red Oak, UF 279-24550. a, b: Wood semi-ring-porous to diffuse-porous; vessels exclusively solitary; thinwalled tyloses in wide vessels; diffuse, diffuse-in-aggregates axial parenchyma; rays of two distinct sizes. TS. c: Rays of two distinct sizes, TLS. d: Vessel-vasicentric tracheid pitting, RLS. e: Vessel-ray parenchyma pitting with reduced borders, vertically elongate, RLS. f: Narrow rays 1-2 cells wide, TLS. g: Ray composed of procumbent cells, RLS. Scale bars: 200 µm in a, b, c; 50 µm in d, f, g; 20 µm in e. in A Diverse Assemblage Of Late Eocene Woods From Oregon, Western Usa
No full textText-fig. 6. Quercus sp. Red Oak, UF 279-24550. a, b: Wood semi-ring-porous to diffuse-porous; vessels exclusively solitary; thinwalled tyloses in wide vessels; diffuse, diffuse-in-aggregates axial parenchyma; rays of two distinct sizes. TS. c: Rays of two distinct sizes, TLS. d: Vessel-vasicentric tracheid pitting, RLS. e: Vessel-ray parenchyma pitting with reduced borders, vertically elongate, RLS. f: Narrow rays 1-2 cells wide, TLS. g: Ray composed of procumbent cells, RLS. Scale bars: 200 µm in a, b, c; 50 µm in d, f, g; 20 µm in e.Published as part of Wheeler, Elisabeth A. & Manchester, Steven R., 2021, A Diverse Assemblage Of Late Eocene Woods From Oregon, Western Usa, pp. 299-329 in Fossil Imprint 77 (2) on page 311, DOI: 10.37520/fi.2021.022, http://zenodo.org/record/716758
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