501 research outputs found
An email survey of midwives knowledge about CytoMegaloVirus (CMV) in Hannover and a skeletal framework for a proposed teaching program
No full textAt present there is lack of information about CMV transmission given to midwives, general practitioners, neonatal pediatricians and nurses, with intrauterine transmission having profound consequences in terms of outcomes for the infected neonate. To identify one particular group of midwives knowledge about CMV, the research question surveyed midwives' knowledge of CMV. A quantitative electronic survey was the research method utilized in this study. To assess midwives knowledge about CMV, the first author emailed colleagues in Hannover and was in receipt of 40 completed questionnaires. Results showed that midwives have gaps in their knowledge about CMV and that an educational program is necessary to enlarge their understandings. Given the catastrophic consequences to the neonate of contracting congenital CMV, it is imperative that both health care professionals and women receive the educational message about prevention. In response an education program for lecturers has been proposed, which consists of eleven learning objectives
GCV-resistant CMV treated by foscarnet
No full textCytomegalovirus (CMV) infection is themost common infectious complication following solid organ transplantation. Ganciclovir (GCV)-resistant CMV infection may be fatal, and is difficult to treat while avoiding allograft rejection. A 31-year-old woman received a second ABO-incompatible kidney transplant, from her father. Induction therapy consisted of basiliximab and rituximab followed by maintenance immunosuppression with tacrolimus, mycophenolate mofetil, and methylprednisolone. Her CMV serostatus was D+/R- at second transplant and she received prophylactic low-dose valganciclovir (VGCV). BK polyoma virus nephropathy (BKVN) developed 7 months after transplant concurrent with CMV hepatitis and retinitis. VGCV was increased to a therapeutic dose combined with reduced immunosuppression with minimal methylprednisolone (2mg/day) and everolimus (0.5mg/day). However, pp65 antigenaemia continued to increase for 6 weeks. Her CMV was defined as ganciclovir (GCV)-resistant. Foscarnet was therefore administered and her CMV disease resolved within 2 weeks. Kidney allograft dysfunction developed 9 months after transplant, and graft biopsy showed tubulointerstitial injury with crystal deposition suggesting foscarnet nephrotoxicity, with no findings of BKVN or rejection. Kidney function recovered after cessation of foscarnet and the patient had good graft function 18 months after transplant. This case demonstrates the successful use of foscarnet to treat GCV-resistant CMV infection after ABO-incompatible kidney transplant complicated with BKVN, without acute allograft rejection. This case further highlights the need to establish appropriate management for CMV D+/R- patients to avoid the acquisition of GCV-resistant gene mutations
Acute Fulminant-Onset Synchronized CMV-Ulcerative Colitis
No full textCytomegalovirus (CMV) is an agent which exists asymptomatically in most individuals and may cause latent life-time infection following contamination. Symptomatic CMV infection develops most commonly in organ transplant recipients and in individuals who receive immunosuppressive drugs, undergo haemodialysis or have acquired immunodeficiency syndrome. The link between ulcerative colitis and CMV infection and the efficacy of antiviral therapy in these individuals have been demonstrated. Due to the fact that synchronous onset of CMV and ulcerative colitis is a very rare clinical condition, we present here a synchronous-onset fulminant CMV and ulcerative colitis in a-58-year-old man without any other co-morbidities
Protective effect of pre-existing immunity against congenital CMV transmission.
No full text(A) Plasma RhCMV-specific PCR in CD4+ T lymphocyte depleted CMV-seronegative primary infected macaques (red; n = 6) compared to both CMV-seropositive reinfected (green; n = 5) and CMV-seropositive controls (grey; n = 3). Area Under the Curve (AUC) values of plasma RhCMV DNA between 0–99 days were compared between groups using the Man-Whitney test. P-values n = 6), CMV-seropositive reinfected (n = 5), and CMV-seropositive controls (n = 3). (C) Kaplan-Meir curve showing cCMV frequency based on RhCMV DNA detection in the amniotic fluid in CMV-seronegative primary infected macaques (n = 6), CMV-seropositive reinfected (n = 5), and CMV-seropositive controls (n = 3). (D) Kaplan-Meier curve showing fetal survival in CMV-seronegative primary infected macaques (n = 6), CMV-seropositive reinfected (n = 5), and CMV-seropositive controls (n = 3). Statistical comparisons by Log-rank (Mantel-Cox) test showing significance levels: * = <0.05 and ** = <0.01.</p
Oral Valganciclovir as a Preemptive Treatment for Cytomegalovirus (CMV) Infection in CMV-Seropositive Liver Transplant Recipients.
No full textCytomegalovirus (CMV) infections in liver transplant recipients are common and result in significant morbidity and mortality. Intravenous ganciclovir or oral valganciclovir are the standard treatment for CMV infection. The present study investigates the efficacy of oral valganciclovir in CMV infection as a preemptive treatment after liver transplantation.Between 2012 and 2013, 161 patients underwent liver transplantation at Samsung Medical Center. All patients received tacrolimus, steroids, and mycophenolate mofetil. Patients with CMV infection were administered oral valganciclovir (VGCV) 900mg/day daily or intravenous ganciclovir (GCV) 5mg/kg twice daily as preemptive treatment. Stable liver transplant recipients received VGCV.Eighty-three patients (51.6%) received antiviral therapy as a preemptive treatment because of CMV infection. The model for end-stage liver disease (MELD) score and the proportions of Child-Pugh class C, hepatorenal syndrome, and deceased donor liver transplantation in the CMV infection group were higher than in the no CMV infection group. Sixty-one patients received GCV and 22 patients received VGCV. The MELD scores in the GCV group were higher than in the VGCV group, but there were no statistical differences in the pretransplant variables between the two groups. AST, ALT, and total bilirubin levels in the GCV group were higher than in the VGCV group when CMV infection occurred. The incidences of recurrent CMV infection in the GCV and VGCV groups were 14.8% and 4.5%, respectively (P=0.277).Oral valganciclovir is feasible as a preemptive treatment for CMV infection in liver transplant recipients with stable graft function
CITOMEGALOVIRUS (CMV) ENCEPHALITIS: A CASE REPORT
No full textEncephalitis results from an inflammatory process in the brain which can be caused by infection, post infection or non-infection processes. The most common etiology is infection, especially by virus. Encephalitis is usually followed by diffuse and or focal neuropsychology dysfunctions of brain and meninges (meningoencephalitis). Symptoms of encephalitis are photophobia, headache or neck stiffness, focal neurological deficits, seizure, decrease of consciousness, behavior disorders, and aphasia. However, some patients may not show predominant neruological deficits or even asymptomatic. Inaccuracy to diagnose the etiology promptly can cause morbidity and mortality due to this disease.
The author reports one case of citomegalovirus (CMV) encephalitis with mild symptoms. In this case, a 36-year old man with symptoms of mild fever and mild headache was consulted by an internist to neurologist, because internal examinations couldn’t find the etiology of the patient’s symptoms. The results of laboratory examinations of NS-1, Dengue IgM and IgG Dengue, Salmonella IgM and IgD, hepatitis screening tests, and chest X-ray examination showed normal results. Brain MRI with contrast then was performed with normal result. Cerebrospinal fluid (CSF) analysis showed pleiocytosis, predominantly mononuclear cells. Diagnosis of CMV encephalitis was established by examination of CMV PCR (Polymerase Chain Reaction) of CSF that was positive. The patient was then treated with antiviral agent Gansiklovir 5 mg/kg every 12 hours for 14 days. On the third day of therapy, the patients had been free of symptoms. The patient was discharged form the hospital in good condition
[CMV-associated enterocolitis due to primary CMV infection in the immunocompetent].
No full textCytomegalovirus (CMV) plays an important role in non-immunocompetent patients due to its high seroprevalence and life-long persistence. However, cases of severe CMV infections are also described in the immunocompetent. Here in particular, the gastrointestinal involvement is of major importance. We describe the case of a 29-year-old immunocompetent young man, who presented with a primary CMV infection mainly of the colon with clinical signs of bloody diarrhoea, fever, hepatitis and haemolysis. The diagnosis was established on the basis of a suspicious endoscopic finding with immunohistochemical detection of CMV in the colonic mucosa, a positive CMV viral load in the peripheral blood and an immune system response typical for primary infection. Based on this case and previous publications, we suggest that a colonoscopy and diagnostic procedures for CMV should be considered if the patient presents with gastrointestinal symptoms like (bloody) diarrhoea, fever, and hepatitis. In a severe case, we recommend antiviral therapy due to a high mortality that has been reported for CMV colitis in immunocompetent individuals
Macular CMV retinitis: a case report.
No full textPURPOSE: Cytomegalovirus (CMV) retinitis is the most common ocular opportunistic infection associated with AIDS. It usually affects the peripheral retina, sparing the macula. We describe an atypical CMV retinitis exclusively confined to the macula. METHODS: A 43-year-old man with the diagnosis of AIDS developed a white retinal lesion confined to the macula of the right eye. Two weeks later, a more typical granular appearance was observed leading to presumption of CMV retinitis. RESULTS: The patient was treated with ganciclovir without success. With foscarnet, a good response was obtained, leading to total healing of the lesion. CONCLUSIONS: CMV retinitis has to be taken into consideration in all lesions confined to the macula in immunodepressed patients. An early diagnosis is crucial to avoid blindness.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
CMV pneumonia following Temozolomide in Primary CNS Lymphoma.
No full textTemozolomide (TMZ) is a second-generation alkylating agent introduced to therapy of primary brain tumors. Using TMZ there is an increased risk of infection. Literature reported several cases of PJ pneumonia but only 6 cases of CMV disease. This case presented the 1st patient with persistent CMV reactivation and CMV disease previously not treated with Rituximab. A 44-year-old man was diagnosed with a occipital-PCNSL. As salvage treatment he was started with whole brain radiotherapy in association with TMZ. After some days CMV-DNA on blood resulted positive so a preemptive tp was commenced. After 2 weeks of Ganciclovir treatment it was replaced with Foscavir for persistent CMV-DNA positivity and the appearance of respiratory failure symptoms, highly suggested for CMV pneumonia.After 5 weeks of treatment,the patient improved and the CMV load became negative
Webis ChangeMyView Corpus 2020 (Webis-CMV-20)
No full textThe Webis-CMV-20 dataset comprises all available posts and comments in the ChangeMyView subreddit from the foundation of the subreddit in 2005, until September 2017. From these, we have derived two sub-datasets for the tasks of persuasiveness prediction, and opinion malleability prediction. In addition, the corpus comprises historical posts by CMV authors, and derived personal characteristics.
Dataset specification
All files are in bzip2-compressed JSON Lines format.
threads.jsonl: contains all the selected discussion threads from CMV
pairs.jsonl: each record contains submission, delta-comment and nondelta-comment and the comments' similarity score
posts-malleability.jsonl: contains posts for opinion mallebility prediction, in the format provided in the original Reddit Crawl dataset
author_entity_category.jsonl: each record contains the author and list of Wikipedia entities mentioned by the author in the messages across all subreddits. For each mentioned entity we provide the following data:
[title, wikidata_id, wikipedia_page_id, mentioned_entity_title, wikifier_score, subreddit_name, subreddit_id, subreddit_category_name, subreddit_topcategory_name]
author_liwc.jsonl: personality traits features computed with LIWC for the authors from pairs.jsonl and post_malleability.jsonl datasets
author_subreddit.jsonl: for each author statistics of all number of all posts (submissions/comments) across all subreddits are provided
author_subreddit_category.jsonl: similar to author_subreddit.jsonl, the statistics of all author posts is grouped by top-categories and categories according to snoopsnoo.co
- …
