1,721,019 research outputs found
Cytological detection of papillary thyroid carcinomas by nuclear membrane decoration with emerin staining.
No full textAbstract Decoration of the nuclear membrane by emerin staining enhances detection of nuclear irregularities typical of papillary thyroid carcinoma (PTC). Our study aims to verify whether staining with emerin is a helpful diagnostic marker in fine-needle aspiration (FNA) cytology. We first designed a prospective study on smears, Thin Prep, and cell block specimens to prove the feasibility of the procedure; subsequently, we designed a retrospective study of 78 FNA cell blocks from cases that, after surgery, turned out to be either benign (34 cases) or malignant lesions (44, of which 31 PTC). From each sample, we obtained two slides, one stained with hematoxylin and eosin (H&E) and the other with emerin. In cases classified as Thy3, HBME-1 and galectin 3 (Gal3) stains had also been performed. Two blinded observers made the judgment concerning Thy categories (as proposed by the British Thyroid Association), first on H&E, then on emerin, HBME-1, and Gal3 stained slides. On cytological preparation, emerin staining represents an effective tool for the detection of nuclear irregularities, allowing for the identification of cases of PTC. In Thy3 cases, emerin staining's sensitivity and specificity (64% and 96%) proved higher than HBME-1' (60% and 88%) and Gal3's (61% and 68%). In conclusion, the immunohistochemical definition of the nuclear membrane, as determined by emerin stain, is a useful tool in the cytological diagnosis of thyroid lesions and can help to solve inconclusive cases by highlighting nuclear irregularities typical of PTC
Nuclear membrane decoration by emerin staining improves cytological detection of papillary thyroid carcinomas
No full textBackground. The diagnosis of follicular lesions is a grey zone in
thyroid fine-needle aspiration (FNA) cytology. Our study aims to
verify if staining with Emerin is a helpful marker of the follicular
variant of papillary thyroid carcinoma (FVPTC) in the differential
diagnosis of follicular-patterned lesions.
Methods. We designed both a prospective study on smears
and Thin Prep specimens to prove the feasibility of the procedure
and a retrospective study on 78 FNA cell-blocks from
cases which, after surgery, turned out to be either benign (34
cases) or malignant lesions (44, of which 31 PTC). From each
sample, we obtained two slides, one stained with Hematoxylin
and Eosin (H&E) and the other with immunohistochemistry
(IHC) for Emerin. In Thy3 cases, HBME-1 and Gal 3 stains
were also done. Two observers gave a judgement in Thy
categories (British Thyroid Association) on H&E, Emerin,
HBME-1 and Gal 3 stained slides.
Results. The prospective study demonstrated that Emerin staining
is an effective tool for nuclear membrane decoration and amplification of nuclear irregularities. In the retrospective study,
inter-observer agreement proved higher in Emerin-stained slides
(K of Cohen-Fleiss = 0.6890) than H&E-stained slides (K of
Cohen-Fleiss = 0.4878). Sensitivity and overall accuracy were
higher for Emerin (respectively, 77.27% and 84.61%) than H&Estained
slides (respectively, 36.36% and 62.82%). Emerin staining
proved able to identify all cases of PTC, including all cases
of FVPTC. In Thy3 cases, Emerin’s sensitivity and specificity
(64% and 96%) proved higher than HBME-1’s (60% and 88%),
and Gal3’s (61% and 68%).
Conclusions. Emerin stain, is a useful tool in the cytological
diagnosis of thyroid lesions. It enhances detection of nuclear
irregularities typical of PTC, thus helping to solve inconclusive
FNA cases, mainly in those cases of FVPTC with a reduced
expression of nuclear irregularities in the traditional stains
(H&E)
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
- …
