1,721,347 research outputs found
Pyridine-2-thiol 1-oxide derivatives and their use for treatment of mammalian infections caused by Mycobacterium or fungi
No full textThe present invention relates to pyridine-2-thiol 1-oxide derivatives and their use as antimicrobial agents in infectious diseases of mammals (humans and animals) caused by fungi or bacteria, in particular belonging to the Mycobacteriaceae family, especially diseases caused by Mycobacterium abscessus or Mycobacterium tuberculosis
A pharmaceutical combination for the treatment of lung infections in subjects with cystic fibrosis
No full textThe present invention relates to a combination therapy for treating infections caused by Mycobacterium abscessus and other microbial pathogens in subjects with cystic fibrosis comprising the sequential, simultaneous or separate administration of pyridine-2-thiol 1-oxides or their salts and cystic fibrosis transmembrane conductance regulator (CFTR) modulators
Nitric oxide-releasing compounds for the treatment of lung infections
No full textThe spread of acquired drug resistance and of microorganisms naturally resistant to antibiotics is a major threat to global health, leading to an urgent need for novel antimicrobial compounds. Exogenous nitric oxide (NO) represents an attractive and promising antimicrobial approach, showing both bactericidal and biofilm dispersal activities. Numerous studies have been performed to develop NO donor scaffolds, including small molecules, macromolecular compounds, nanoparticles (NPs), and polymeric materials. This approach has resulted in successful outcomes, with some NO-releasing compounds entering clinical practice. In this review, we highlight the importance of this strategy, with a focus on lung infections
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Erratum: Okrepilov V. V., Makarov V. L., Bakhtizin A. R., Kuzmina S.N. (2015). Application of Supercomputer Technologies for Simulation Of Socio-Economic Systems. Economy of Region [Economy of region], 2, 301–313, https://doi. org/10.17059/2017-2-1
No full textIn order to сover a more wide thematic audience of the journal Economy of Regiona, the authors Okrepilov V. V., Makarov V. L., Bakhtizin A. R., Kuzmina S. N. of the paper Application of Supercomputer Technologies for Simulation Of Socio-Economic Systems, published in the 2nd Issue, 2015 used the materials of previously published paper “Supercomputer Technologies Application in Social Sciences”, Economics and Mathematical Methods, Vol. 49 (4), 2013 and “Supercomputer Technologies Application in Social Sciences”, UPRAVLENIE / MANAGEMENT (Russia), Issue 2, 2014 (DOI 10.12737/4167).
The works used the same methods developed by the authors, but different results were obtained. A link to a previously published articles is included in the electronic version of the article Okrepilov V. V., Makarov V. L., Bakhtizin A. R., Kuzmina S. N. (2015). Application of Supercomputer Technologies for Simulation Of Socio-Economic Systems. Economy of Region [Economy of region]
The works used the same methods developed by the authors, but different results were obtained. A link to a previously published articles is included in the electronic version of the article Okrepilov V. V., Makarov V. L., Bakhtizin A. R., Kuzmina S. N. (2015). Application of Supercomputer Technologies for Simulation Of Socio-Economic Systems. Economy of Region [Economy of region, 2, 301–313
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Erratum: Okrepilov V. V., Makarov V. L., Bakhtizin A. R., Kuzmina S.N. (2015). Application of Supercomputer Technologies for Simulation Of Socio-Economic Systems. Economy of Region [Economy of region], 2, 301–313, https://doi. org/10.17059/2017-2-1
No full textIn order to сover a more wide thematic audience of the journal Economy of Regiona, the authors Okrepilov V. V., Makarov V. L., Bakhtizin A. R., Kuzmina S. N. of the paper Application of Supercomputer Technologies for Simulation Of Socio-Economic Systems, published in the 2nd Issue, 2015 used the materials of previously published paper “Supercomputer Technologies Application in Social Sciences”, Economics and Mathematical Methods, Vol. 49 (4), 2013 and “Supercomputer Technologies Application in Social Sciences”, UPRAVLENIE / MANAGEMENT (Russia), Issue 2, 2014 (DOI 10.12737/4167).
The works used the same methods developed by the authors, but different results were obtained. A link to a previously published articles is included in the electronic version of the article Okrepilov V. V., Makarov V. L., Bakhtizin A. R., Kuzmina S. N. (2015). Application of Supercomputer Technologies for Simulation Of Socio-Economic Systems. Economy of Region [Economy of region], 2, 301–313
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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