387 research outputs found
The Man, The Boy, and The Donkey
No full textMSA is here told in Amharic. Our 79th language! The story is told in typical fashion, though the ending is surprising. There is no death of the donkey, nor is there a decision by the man. The last word goes to passersby who comment "You fools! Do you carry donkeys?" The moral is, in Google translate, "If you try to please everyone, you can please no one." Strong simple illustrations have the two walking through desert to Gebiya. 46 pages. 6" x 9".This is a hardbound book (hard cover)Language note: AmharicNo Autho
Epidemiology of MSA : HoRC-MSA project
No full textMultiple system atrophy (MSA) is an intractable neurodegenerative disorder that is characterized by various combinations of autonomic failure, cerebellar ataxia, and parkinsonism. We conducted an epidemiological study of MSA using the combined data of a national registry system and a postal survey in Hokkaido, Japan. A postal survey was conducted in 2013 based on national registry data from 2006 to 2011. This survey contained the current status of each patient with MSA that had been collected from attending physicians and recorded into a national registry. Survey items included date, outcomes, primary symptoms, and activities of daily living at the last medical examination. Confirmation data of the diagnosis by a board-certified neurologist was also collected. Based on the national registry data, 1,092 patients with MSA were selected as our target population. The response rate of the postal survey was 81 % (885/1,092). After excluding inappropriate responses, 839 patients with MSA were analyzed. Forty-nine percent of the patients were male, and the mean onset age was 62.1 +/- 10.4 years. A Kaplan-Meier survival curve revealed that patients with onset symptoms of cerebellar ataxia had a better prognosis than those with onset of parkinsonism or autonomic failure (p < 0.01). Additionally, we found that a higher onset age was associated with poor prognosis. We found that patients with cerebellar ataxia at onset had a better survival prognosis than those with parkinsonism or autonomic failure at onset and that patients with an older age at onset had a worse survival prognosis
MSA-C is the predominant clinical phenotype of MSA in Japan : Analysis of 142 patients with probable MSA
No full textWe investigated the clinical features and mode of disease progression in 142 patients with probable multiple system atrophy (MSA) according to the Consensus Criteria. The subjects included 84 men and 58 women with a mean age at onset of 58.2 ± 7.1 years (range: 38–79 years). Cerebellar signs were detected in 87.3% of these patients at the time of initial examination, and were found in 95.1% of them at latest follow-up. MSA-C was diagnosed in 83.8% of the patients at their first examination. Parkinsonism was initially detected in 28.9% of the patients, increasing to 51.4% at the latest follow-up. Among all of the subjects, only 16.2% were classified as having MSA-P on initial examination. At the latest follow-up, parkinsonian features had become predominant over cerebellar features in 24.6% of the 65 patients with MSA-C who were followed for more than 3 years. Although parkinsonism usually masked the signs of cerebellar involvement in MSA-C patients, none of the patients with MSA-P at an early stage showed predominance of cerebellar features at the latest follow-up. Parkinsonism is the predominant feature of MSA among Western patients, even at an early stage, but this study showed that cerebellar deficits are the main feature in Japanese patients. This difference of disease manifestations between ethnic groups suggests that genetic factors may influence the clinical phenotype of MSA
Menopause Symptom Assessment (MSA) - 1994
No full textMSA is copyrighted (1994) by the author. Data supplied states that there is no charge for using the instrument, which may be copied for research purposes, provided that proper acknowledgment is used in all publications and that the author is provided with a summary of the data including MSA score frequencies and psychometric properties. Instrument consists of six pages and accompanying information from the author concerning scoring, psychometric properties,reliability, use of the MSA, and reference list.The Menopause Symptom Assessment (MSA) was developed by researcher Judith A. Headley as a 32 item, 16-symptom Likert scale which measures the frequency of the symptom separately from the severity, or distress caused by the symptom. The MSA also includes two open-ended questions
Scaling analysis based on extremal point topology
No full textThe interaction of different scales is among the most interesting and challenging features in turbulence research. Existing approaches used for scaling analysis such as structure-function and Fourier spectrum method have their respective limitations, for instance scale mixing, i.e. the so-called infrared and ultraviolet effects. To make improvement in this regard, a new method, multi-level segment analysis (MSA) based on the local extrema statistics, has been developed. Data test results show that MSA can successfully reveal different scaling regimes in complex systems such as Lagrangian and two-dimensional turbulence, which have been remaining controversial in turbulence research. In principle MSA can generally be applied for various analyses
Detecting anti-patterns in a MSA using distributed tracing: Detecting anti-patterns in a MSA using distributed tracing at ING
No full textMicroservice architectures (MSA) have become a dominant architectural style choice in the service oriented software industry. Because of this, as with any other system, some unoptimized approaches might creep into architectures. These are what we call anti-patterns, they can be considered the opposite of design patterns. Furthermore, a microservice architecture can quickly grow to an immense scale due to the number of services. In this work, we present Luduan, a tool created within ING that provides engineers with insights into their MSA. Using different graph metrics and tracing data, we determine the likelihood of any service containing certain anti-patterns. We validate this methodology by gathering feedback from subject-matter experts, by ways of surveys and one-on-one sessions where Luduan is used as a support tool. Finally, we ask teams that are responsible for services, to figure out whether their service has an anti-pattern or not. We then use these results to fine tune the computations from metrics to anti-pattern likelihood.Computer Science | Software Technolog
Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology
No full textMultiple-system atrophy (MSA) is a rapidly progressive neurodegenerative disease of unknown cause, typically affecting individuals aged 50-60 years and leading to death within a decade1-3. It is characterized by glial cytoplasmic inclusions (GCIs) composed of fibrillar α-synuclein (aSyn)4-8, the formation of which shows parallels with prion propagation9,10. While fibrils extracted from brains of individuals with MSA have been structurally characterized11, their ability to replicate in a protein-only manner has been questioned12, and their ability to induce GCIs in vivo remains unexplored. By contrast, the synthetic fibril strain 1B13,14, assembled from recombinant human aSyn, self-replicates in vitro and induces GCIs in mice15-suggesting direct relevance to MSA-but lacks scrutiny at the atomic scale. Here we report high-resolution structural analyses of 1B fibrils and of fibrils extracted from diseased mice injected with 1B that developed GCIs (1BP). We show in vivo that conformational templating enables fibril strain replication, resulting in MSA-like inclusion pathology. Notably, the structures of 1B and 1BP are highly similar and mimic the fold of aSyn observed in one protofilament of fibrils isolated from patients with MSA11. Moreover, reinjection of crude mouse brain homogenates containing 1BP into new mice reproduces the same MSA-like pathology induced by the parent synthetic seed 1B. Our findings identify 1B as a synthetic pathogen capable of self-replication in vivo and reveal structural features of 1B and 1BP that may underlie MSA pathology, offering insights for therapeutic strategies.
© 2025. The Author(s)
Foreword in 'Architecture, Literature and a City'
No full textThe book explores a collaborative studio design project carried out by stage 4 MSA students with six other European Schools of Architecture. The project explores the cultural and architectural influences of literature on the urban domain. Working closely with the Scottish Writers' Centre, students explored the design of a public forum for the activity and dissemination of literature: An urban literature Institute. The Preface explores the relationship between the author of words and the author of buildings and speculates about the significance of such international collaborations (this being the third iteration)
The geography of technopoles : computer and electronic product manufacturing by MSA, 2005
No full text"The purpose of this thesis was to examine and better explain the spatial distribution of computer and electronic product manufacturing employment by MSA. It will be argued that the geography of computer and electronic product manufacturing is strongly linked to specific socio-economic variables and particularly Richard Florida's Creative Index score by MSA. The analysis was based on a series of non-parametric Spearman's Rank Correlation Coefficients, which were used to determine if statistically significant relationships existed between the dependent and independent variables. In general, the geographical dispersion of computer and electronic product manufacturing employment has statistically significant relationships with educational attainment, median value of homes, and the percent of a population born outside the United States. However Richard Florida's Creative Index generated the highest correlation coefficient score, when compared to the percentage of the labor force employed in computer and electronic product manufacturing by MSA."--Abstract from author supplied metadata
Latitudinal and Seasonal Distribution of Particulate MSA over the Atlantic using a Validated Quantification Method with HR-ToF-AMS
No full textMethanesulfonic acid (MSA) has been widely used as a proxy for marine biogenic sources, but it is still a challenge to provide an accurate MSA mass concentration with high time resolution. This study offers an improved MSA quantification method using high resolution time of-flight aerosol mass spectrometer (HR-ToF-AMS). Particularly, the method was validated based on an excellent agreement with parallel offline measurements (slope = 0.88, R-2 = 0.89). This comparison is much better than those using previously reported methods, resulting in underestimations of 31-54% of MSA concentration. With this new method, MSA mass concentrations were obtained during 4 North/South Atlantic cruises in spring and autumn of 2011 and 2012. The seasonal and spatial variation of the particulate MSA mass concentration as well as the MSA to non-sea-salt sulfate ratio (MSA:nssSO(4)) over the North/South Atlantic Ocean were determined for the first time. Seasonal variation of the MSA mass concentration was observed, with higher values in spring (0.03 mu g m(-3)) than in autumn (0.01 mu g m(-3)). The investigation of MSA:nssSO(4) suggests a ubiquitous and significant influence of anthropogenic sources on aerosols in the marine boundary layer.Gottfried Wilhelm Leibniz Association (OCEANET project); [AWI_ANT27/4]; [AWI_ANT28/1]; [AWI_ANT28/5]; [AWIANT29/1]SCI(E)ARTICLE1418-4265
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