1,568 research outputs found
EUTOS score predicts early optimal response to imatinib according to the revised 2013 ELN recommendations.
No full text"Gentlemen, I'm not happy" : Divagazioni su "Commento/Tormento"
No full textIn a paper published in "Eikasmos" 2005, pp. 409-418, "Commento/Tormento: eccessi antichi e moderni nell'esegesi dei classici", Mario Geymonat investigated the existing typologies of commentaries to the Classics, from Late Antiquity to our days. In this paper, the author examines the classification proposed by Geymonat, and draws attention to the possibilities of a new type of commentary in the Age of Internet
L'archivio dei Frati Minori Cappuccini di Bologna per la storia dell'arte sacra
No full textPer lo studio della storia dell'arte gli archivi sono una fonte di informazioni indispensabile ad ogni ricerca. A Bologna si conserva l'archivio dei Frati Minori Cappuccini del convento di San Giuseppe Sposo di Maria, prima casa della famiglia nata dalla volontà di alcuni di riportare la famiglia francescana all'antico rigore, all'epoca prima della Riforma Cattolica. Il testo in questione descrive le carte custodite in tale archivio, il sistema di classificazione, i caratteri dei documenti, la storia dei provvedimenti intrapresi nei secoli allo scopo di custodire e trasmettere nella loro interezza tali memorie, una vicenda di particolare interesse per comprendere l'evoluzione del pensiero nelle diverse epoche
Development of wheat allergoids for the treatment of baker's asthma
No full textBackground. Occupational exposure to inhaled proteins of wheat flour may be responsible of occupational allergies, such as baker’s asthma (BA) with a prevalence of nearly 30% among workers in industries, mills and bakeries. Up-to-date no effective specific immunotherapy (SIT) is available for the treatment of BA. The main reasons are probably the co-presence of multiple allergens in wheat and the heterogeneity of patients’ sensitization profiles. The aim of the present work is the development of wheat allergoid with reduced allergenic potency still retaining immunogenic properties to be employed in SIT for the treatment of BA.Method. The salt-soluble protein fraction was extracted by PBS from a widely utilized wheat cultivar. The flour extract (FE) was subjected to chemical modification of amino-groups with 1) potassium cyanate (K), 2) succinic anhydride (SA) and 3) acetic anhydride (AA). The three modified FE (MFEs) were assayed by immunoblotting with the sera of subjects (from the north-east part of Italy) suffering from BA (N=14) and with polyclonal antibodies specific for the major allergen α-amylase inhibitors (αAIs). K-MFE and FE were used to immunize Balb/c mice (n. 5 mice per group) with Freund’s adjuvant. Antibody titres were quantified by ELISA and the binding patterns characterized by immunoblotting. Immunodetected proteins were identified by 2D electrophoresis (2DE) and mass spectrometry (MS).Results. The immunodetection experiments confirmed an overall reduction of the IgE-binding capacity of all MFEs with very close profiles, indicating that part of the epitopes involve the aminoacid lysine, while the specific binding of the anti-αAIs antibodies was minimally affected. The immunization raised in mice different antibodies with specificity for multiple wheat proteins. The binding patterns of MFEs were almost identical and reproducible except for a 14 kDa protein recognized only by the IgG of K-MFE-injected mice. Surprisingly, the protein was detected in both FE and MFE. The separation of K-MFE and FE by 2DE showed that this protein is composed by a group of polypeptides with different isoelectric points. MS identified these proteins as αAIs.Conclusions. The raising of antibodies specific to αAIs upon administration of K-MFE might have a protective role by competing with IgE in allergen-binding. Further tests, e.g. histamine release and T cell activation, will help to evaluate the capacity of MFEs to modulate the immune response
Macrohematuria caused by a fall in prothrombin activity as a clinical presentation of celiac disease. (I.F. 1.357)
No full textLong-term skeletal and dentoalveolar effects of hybrid rapid maxillary expansion and facemask treatment in growing skeletal Class III patients: a retrospective follow-up study
No full textBACKGROUND: Regardless of the treatment protocol, stability in Class III patients always represents a major concern. The aim of this study was to assess the short and long-term skeletal and dentoalveolar modifications in a group of class III patients treated with hybrid rapid maxillary expander (RME) and facemask (FM). Indeed, no long-term studies have been conducted yet with the objective of evaluating the effects of this kind of approach when applied to patients who have already gone thought their peak of growth. MATERIAL AND METHODS: 27 patients with skeletal Class III malocclusion were treated using hybrid RME according to alternating rapid maxillary expansion and constriction (ALT-RAMEC) protocol, followed by 4 months of facemask therapy. After the orthopaedic phase, each patient underwent orthodontic treatment with fixed multibracket appliances. A mean follow-up of 7 years, 10 months was performed. Pre-treatment (TO), post-treatment (T1) and follow up (T2) cephalometric tracing were analysed, comparing dental and skeletal measurements. RESULTS: Point A advanced by a mean of 3.5 mm with respect to VerT, then relapsed by 0.7 in the post-facemask period, thereby yielding of a mean advancement of 2.7 at T2. The sagittal relationship significantly changed after RME + facemask protraction (3.8° of ANB and 5.189 mm of Wits). Although both Wits and ANB values worsened over time, the improvement from T0 is still appreciable at T2. CONCLUSION: Despite the physiological relapse due to mandibular growth, the long-term cephalometric follow-up confirms the maintenance of all positive outcomes of the previous orthopaedic treatment with hybrid RME and facemask
Prevention of complications and symptomatic recurrences in diverticular disease with mesalazine: a 12-month follow-up.
No full textInternational Standards for the Induction Motor Efficiency Evaluation: a Critical Analysis of the Stray-Load Losses Determination
No full textMotor efficiency has to be measured or calculated in accordance with international standards. The most important standards are the IEEE 112-B, IEC 34-2, and JEC 3 . In this paper, a comparison of the measurement procedures defined by these international standards is reported, together with some comments on the prescribed methodologies. The comparison is based on experimental results obtained by tests on four general-purpose three-phase induction motors. The stray-load loss measurement represents a critical key for the correct evaluation of the motor efficiency. For this reason, a critical analysis of this type of losses has been performed. In particular, in order to understand which are the most critical quantities that influence their evaluation, the stray-load loss sensitivity to the measurement errors is analyzed. In the final part of the paper the temperature influence, on the conventional iron losses, is experimentally analyzed. The performed tests show that the temperature difference between the no-load test and the motor real operative conditions is not negligible
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