103,226 research outputs found
Biomolecular Corona Affects Controlled Release of Drug Payloads from Nanocarriers
No full textNanomedicine has been widely used for a wide range of biomedical applications including drug delivery. Although many factors including the physicochemical properties of nanoparticles (NPs) and the payload efficacy of nanocarriers have been thoroughly investigated, the crucial role of the biomolecular corona in drug delivery and the release efficacy of nanocarriers demands further attention. This review highlights not only the crucial importance of the biomolecular corona to the drug release capacity of various types of nanocarriers, but also its interfer-ence with drug release measurements. A full consideration of the effects of the biomolecular corona on the controlled release and drug delivery of nanocarriers will help researchers design safer and more efficient nanobased drug delivery systems
Reti di fibre colloidali sotto sforzo : deformazione di taglio e carico gravitazionale
No full textWe describe our investigation of the yield behavior of a network of hydrophobic fibers in an aqueous surfactant solution, when submitted either to a macroscopic shear stress or to the gravitational load of density-mismatched particles. In both cases, the gel undergoes an initial, slow deformation followed by delayed yielding or respectively collapse. However, the time scales for the yielding process strongly differ from each other both on an absolute scale and in their dependence on the effective stress applied. We discuss the analogies, the differences and the interplay between these destabilization modes
Colloidal fiber networks under stress : shear versus gravitational load
No full textColloidal gels are widely used in applications to modify the mechanical properties of fluids; in particular, they can provide yield stress, i.e. the ability to display solid-like properties at rest, while flowing upon application of a mechanical load. In this contribution we describe the yield behavior of a colloidal fiber network when it is subjected either to a macroscopic shear stress, or to a gravitational load obtained by inserting density-mismatched particles into the network. Delayed yielding is observed in both experiments. However, the time scales for the yielding process strongly differ from each other both on an absolute scale and in their dependence on the effective stress applied. We discuss how delayed yielding depends on background viscosity, intrinsic network relaxations, and on network porosity and elasticity
Effect of molecular crowding on the biological identity of liposomes: an overlooked factor at the bio-nano interface
No full textOnce embedded in a physiological environment, the surface of nanoparticles (NPs) gets covered with a biomolecular corona (BC) that alters their synthetic characteristics and subsequently gives them a peculiar biological identity. Despite recent studies having clarified the role of NP composition, surface chemistry and biological source (e.g., human/animal serum or plasma) in the formation of the BC, little is known about the possible impact of molecular crowding. To fill this gap, we used a cationic liposomal formulation as a model system and studied its biological identity upon incubation with human plasma, at a fixed liposome-to-plasma volume ratio and different concentrations. We carried out dynamic light scattering measurements to quantify the size and zeta potential of the investigated systems and gel electrophoresis to evaluate the composition of the corresponding coronas. Our findings suggest that NP stability may be compromised by molecular crowding, but the corona composition is stable over a wide range of concentrations, which extend over more than two orders of magnitude. As the biological identity of NPs eventually determines their final fate in vivo, we predict that this study could contribute to the development of a safe and effective nanosystem for the targeted delivery of therapeutic agents
A practical method for estimating efficiency maps for PM machines using a reduced number of tests
No full textMeasuring the efficiency map of an electric machine is a complex and time-consuming process. This paper examines means for estimating the efficiency map of PM machines using a reduced number of tests. It uses a modified saturation model which gives good results even in the presence of high cross-saturation. It also models the iron loss variation with load and speed using curve fitting in the constant torque and power regions based on a limited number of load points. Both the flux-linkage and iron loss methods are applicable to finite element (FE) simulation and have the capability of being generalized to other electrical machine types. The results are verified both with FE simulation and experimental tests
Bibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Bicelle-Bicelle lamellar stacking of a fatty alcohol and a C8–10 alkyl PolyGlycoside surfactant
No full textBio-based surfactants, such as alkyl polyglucosides (APG), exhibit non-classical surfactant behavior due to their sugar-based hydrophilic head groups. The self-assembly behavior of Triton CG110 (C8 alkyl chain APG) was examined in the presence and absence of 1-dodecanol (C12OH) using small-angle X-ray and neutron scattering (SAXS and SANS). These techniques allowed for the characterization of aggregate structures and the determination of phase transitions as a function of surfactant concentration and composition. SAXS and SANS analyses revealed that Triton CG110 alone forms bicelles in water. Upon addition of C12OH, mixed bicelles were observed at low concentrations, indicating co-assembly of the two surfactants. At higher surfactant concentrations,
maintaining a fixed Triton CG110:C12OH ratio, a bicelle-to-lamellar transition occurred due to bicelle stacking, while the common lamellar packing adopts a mixed lamellar stacking, where different molecules integrate within the lamellar arrangement. These structural transitions explain the observed non-linear rheological behavior and suggest potential applications for Triton CG110 in systems requiring tailored mesophase structures
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3346: Samuel G. Freedman, author, 2013
No full textPhotograph of author Samuel G. Freedman, at NT Daily Slash meeting in the Mayborn School of Journalism at UNT
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