5 research outputs found
A Critique and study of a narrative of the Fatimids of Egypt and the Ismaili based on the story of Bustan-e-Khayal (Based on historical sources)
No full textStories and tales as an important part of popular culture are the connection between people now and the past that transmits cultural and doctrinal principles from one generation to another. Based on the approaches of modern historiography and the narrative context of historical narratives, some stories also contain historical contexts that are useful to study alongside historical sources. The myth of Bustan-e-Khayal is a folk tale based on the history of the Fatimid caliphs of Egypt and the Ismaili Shiites, which begins based on historical events that took place during. The author has brought these historical figures into the realm of myth, attributing imaginary stories to them. This article follows the presence of the Ismaili religion and the Fatimid caliphs in this story and critiques it based on historical sources and narratives in a descriptive-analytical manner. The findings of this study and their critique indicate the empirical confirmation of some of the author's narrations Based on the historical and doctrinal sources of this political and religious sect, but in some cases, there were differences. The extraordinary face that the author presents of some of the Fatimid caliphs was very close to the aspect of the sanctity and divinity of these caliphs, which has been confirmed by the testimony of historical narrator
Remembering the legacy of Professor Mohammad Hashemi: a pioneer in molecular genetic studies in southeast Iran (1965–2019)
No full textProfessor Mohammad Hashemi was a clinical biochemist, and cancer genetics scientist. He has been chair and head of department of clinical biochemistry at Zahedan University of Medical Sciences, Zahedan, Iran. He has played an important role in the improvement of understanding of genetics of disease in southeast Iran. He was also a part of international team for the discovery of the role of calprotectin (S100A8/A9) in cancer biology via regulation of cell fate in tumor cells. He had over 300 peer reviewed scientific publications and trained significant numbers of high quality personals (>40) in the field of biomedical sciences. His sudden death in 2019, shocked national and international scientific society but his scientific legacy will remain alive forever.The presentation of the authors' names and (or) special characters in the title of the pdf file of the accepted manuscript may differ slightly from what is displayed on the item page. The information in the pdf file of the accepted manuscript reflects the original submission by the author
The Integration Program of Prevention and Treatments of Substance Use and HIV/AIDS in the Rural Primary Health Care (PHC) System of Iran
No full textA spatio-temporal agent-based approach for modeling the spread of zoonotic cutaneous leishmaniasis in northeast Iran
No full textBackground: Zoonotic cutaneous leishmaniasis (ZCL) is a neglected tropical disease worldwide, especially the Middle East. Although previous works attempt to model the ZCL spread using various environmental factors, the interactions between vectors (Phlebotomus papatasi), reservoir hosts, humans, and the environment can affect its spread. Considering all of these aspects is not a trivial task. Methods: An agent-based model (ABM) is a relatively new approach that provides a framework for analyzing the heterogeneity of the interactions, along with biological and environmental factors in such complex systems. The objective of this research is to design and develop an ABM that uses Geospatial Information System (GIS) capabilities, biological behaviors of vectors and reservoir hosts, and an improved Susceptible-Exposed-Infected-Recovered (SEIR) epidemic model to explore the spread of ZCL. Various scenarios were implemented to analyze the future ZCL spreads in different parts of Maraveh Tappeh County, in the northeast region of Golestan Province in northeastern Iran, with alternative socio-ecological conditions. Results: The results confirmed that the spread of the disease arises principally in the desert, low altitude areas, and riverside population centers. The outcomes also showed that the restricting movement of humans reduces the severity of the transmission. Moreover, the spread of ZCL has a particular temporal pattern, since the most prevalent cases occurred in the fall. The evaluation test also showed the similarity between the results and the reported spatiotemporal trends. Conclusions: This study demonstrates the capability and efficiency of ABM to model and predict the spread of ZCL. The results of the presented approach can be considered as a guide for public health management and controlling the vector populationFigure not available: see fulltext.. © 2020, The Author(s)
Comparison of in-vitro immunomodulatory capacity between large and small apoptotic bodies from human bone marrow mesenchymal stromal cells
No full textBackground
Mesenchymal stromal cell (MSC) apoptosis is essential for their therapeutic effects, including immunomodulation. Previous studies have shown that MSC-derived apoptotic bodies (ApoBDs) also possess immunomodulatory properties. However, compared to small extracellular vesicles, the preparation, characterization, and biological properties of ApoBDs remain underexplored.
Results
ApoBDs were isolated from the conditioned medium of staurosporine-induced apoptotic human MSCs and categorized into large (∼700 nm) and small (∼500 nm) groups. Both types expressed CD90, CD44, and CD73, with low levels of PD-L1, CD11b, and HLA-DR, mirroring their parental MSCs. Functional assays revealed that both ApoBDs inhibited allogeneic T-cell proliferation, with large ApoBDs demonstrating superior efficacy. In macrophage co-culture experiments, both ApoBDs polarized M1 macrophages toward an M2-like phenotype, with large ApoBDs more effectively upregulating CD163 expression. Additionally, both ApoBDs suppressed the proliferation of murine primary T cells. Furthermore, large ApoBDs exhibited enhanced macrophage uptake, as confirmed by flow cytometry and immunocytochemistry. Importantly, no cytotoxicity was observed for either ApoBD type following staurosporine treatment.
Conclusions
Staurosporine-induced ApoBDs are non-cytotoxic and exhibit significant immunomodulatory potential in vitro. Large ApoBDs are more effective than small ApoBDs in T-cell suppression and M2 macrophage polarization, suggesting their potential as an alternative to MSC-based therapies in future studies.Jiemin Wang acknowledges the financial support from the China Scholarship Council (202006370067). This work was partly funded by the European Union under grant agreement number 101080611 (Restore Vision). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or European Health And Digital Executive Agency (HADEA). Neither the European Union nor HADEA can be held responsible for them. This work has also emanated from research supported in part by a grant from Taighde Éireann – Research Ireland and the European Regional Development Fund (ERDF) under grant number 13/RC/2073_P2 at CÚRAM Research Ireland Centre for Medical Devices. Fig. 1A was created by Biorender.peer-reviewe
