547 research outputs found

    Author response image 1.

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    Neurotransmitter is released at synapses by fusion of synaptic vesicles with the plasma membrane. To sustain synaptic transmission, compensatory retrieval of membranes and vesicular proteins is essential. We combined capacitance measurements and pH-imaging via pH-sensitive vesicular protein marker (anti-synaptotagmin2-cypHer5E), and compared the retrieval kinetics of membranes and vesicular proteins at the calyx of Held synapse. Membrane and Syt2 were retrieved with a similar time course when slow endocytosis was elicited. When fast endocytosis was elicited, Syt2 was still retrieved together with the membrane, but endocytosed organelle re-acidification was slowed down, which provides strong evidence for two distinct endocytotic pathways. Strikingly, CaM inhibitors or the inhibition of the Ca2+-calmodulin-Munc13-1 signaling pathway only impaired the uptake of Syt2 while leaving membrane retrieval intact, indicating different recycling mechanisms for membranes and vesicle proteins. Our data identify a novel mechanism of stimulus-and Ca2+-dependent regulation of coordinated endocytosis of synaptic membranes and vesicle proteins

    N=2 supersymmetric dynamics for pedestrians

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    Understanding the dynamics of gauge theories is crucial, given the fact that all known interactions are based on the principle of local gauge symmetry. Beyond the perturbative regime, however, this is a notoriously difficult problem. Requiring invariance under supersymmetry turns out to be a suitable tool for analyzing supersymmetric gauge theories over a larger region of the space of parameters. Supersymmetric quantum field theories in four dimensions with extended N=2 supersymmetry are further constrained and have therefore been a fertile field of research in theoretical physics for quite some time. Moreover, there are far-reaching mathematical ramifications that have led to a successful dialogue with differential and algebraic geometry. These lecture notes aim to introduce students of modern theoretical physics to the fascinating developments in the understanding of N=2 supersymmetric gauge theories in a coherent fashion. Starting with a gentle introduction to electric-magnetic duality, the author guides readers through the key milestones in the field, which include the work of Seiberg and Witten, Nekrasov, Gaiotto and many others. As an advanced graduate level text, it assumes that readers have a working knowledge of supersymmetry including the formalism of superfields, as well as of quantum field theory techniques such as regularization, renormalization and anomalies. After his graduation from the University of Tokyo, Yuji Tachikawa worked at the Institute for Advanced Study, Princeton and the Kavli Institute for Physics and Mathematics of the Universe. Presently at the Department of Physics, University of Tokyo, Tachikawa is the author of several important papers in supersymmetric quantum field theories and string theory

    Seven connection patterns between the author research areas.

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    Seven connection patterns between the author research areas.</p

    Synthesis of Supported Bimetal Catalysts using Galvanic Deposition Method

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    Supported bimetallic catalysts have been studied because of their enhanced catalytic properties due to metal‐metal interactions compared with monometallic catalysts. We focused on galvanic deposition (GD) as a bimetallization method, which achieves well‐defined metal‐metal interfaces by exchanging heterogeneous metals with different ionisation tendencies. We have developed Ni@Ag/SiO2 catalysts for CO oxidation, Co@Ru/Al2O3 catalysts for automotive three‐way reactions and Pd−Co/Al2O3 catalysts for methane combustion by using the GD method. In all cases, the catalysts prepared by the GD method showed higher catalytic activity than the corresponding monometallic and bimetallic catalysts prepared by the conventional co‐impregnation method. The GD method provides contact between noble and base metals to improve the electronic state, surface structure and reducibility of noble metals.ファイル公開:2019-09-01journal articl

    Effects of phytic acid sorption on iron polymerization and at the ferrihydrite-water interface

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    Phytic acid is the most predominant organic phosphorus species in soils. Its stability in soils is mainly due to its high affinity for soil colloids, especially Fe (oxyhydr)oxides. They have been acknowledged as mobile/reactive adsorbents for P in soil-water environments. Although several sorption mechanisms were proposed, it is not clear how multi phosphate groups of phytic acid contribute to the surface complexation and/or precipitation processes. In this study, sorption behavior of phytic acid in ferrihydrite was examined using experimental geochemistry, solution 31P nuclear magnetic resonance spectroscopy, X-ray diffraction and scanning electron microscopy. The results indicated inner-sphere surface complexation via P1,3 and P2 functional groups under both pH 5 and 8.5. Under alkaline pH, an additional P5 functional group became active. Coprecipitation experiments showed evidence of the formation of Fe(III)-phytate-like bulk precipitates when the initial phytic acid/Fe(III) molar ratio was high (0.45-0.5). At the low phytic acid/Fe(III) (<0.1), the formation of ferrihydrite was unaffected, but further transformation was still inhibited. The study suggests a new role of phytic acid in the formation of Fe oxyhydroxide minerals.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2021-05-01The student, Ai Chen, accepted the attached license on 2019-03-22 at 09:27.The student, Ai Chen, submitted this Thesis for approval on 2019-03-22 at 09:39.This Thesis was approved for publication on 2019-03-25 at 10:06.DSpace SAF Submission Ingestion Package generated from Vireo submission #13441 on 2019-08-22 at 16:20:26Made available in DSpace on 2019-08-23T20:44:35Z (GMT). No. of bitstreams: 2 CHEN-THESIS-2019.pdf: 1920983 bytes, checksum: 29cd594d8d0011039bf498f5ec805648 (MD5) LICENSE.txt: 4204 bytes, checksum: 2acc9ddd552dbf2984db2bbd626e9a2b (MD5) Previous issue date: 2019-03-25Embargo set by: Seth Robbins for item 112265 Lift date: 2021-08-23T20:44:50Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 112265 Lift date: 2021-08-23T20:46:41Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 112265 Lift date: 2021-08-23T20:47:38Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 112265 Lift date: 2021-08-23T20:48:32Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemLimited Restriction Lifted for Item 112265 on 2021-08-24T09:15:10Z

    Design of Oxidation Catalysts Based on Bimetal Effect among Two Metal/Metal Oxide Components

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    名古屋大学Nagoya University博士(工学)doctoral thesi

    OBSERVATION OF THE BULB TYPE TILTMETER IN THE LANDSLIDES

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    In this paper, the author had studied thr relationship between variation of tiltineter andlandslide movement observing bulb type tiltmeters~ in the creep type landslides. From the resultsof them, the variation of tiltmeter in landslide is related with the landslide movement of creep type.When we make judge the landslide movement from variation of inclination on the soil surface, it is usefull to confer the standard curves that was maked by observational facts.The critical inclination for soil movement, is assumed about 4"/day as N-S and E-W com-ponent respectivelly.In this paper, the author had studied thr relationship between variation of tiltineter andlandslide movement observing bulb type tiltmeters~ in the creep type landslides. From the resultsof them, the variation of tiltmeter in landslide is related with the landslide movement of creep type.When we make judge the landslide movement from variation of inclination on the soil surface,it is usefull to confer the standard curves that was maked by observational facts.The critical inclination for soil movement, is assumed about 4"/day as N-S and E-W com-ponent respectivelly

    Mesotomisation of Diammine=dinitro=oxalo=cobalt Complex and Determination of the Configurations of this Complex and of Diammine=tetranitro=cobalt Complex

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    1. Diammine-dinitro-oxalo-cobalt complex [Co(NH3)2(NO2)2C2O4]Me has been resolved into the optically active isomers by fractionation of the salts of brucine, strychinine and cinchomine. 2. In the fractionation of the alkaloid salts of the complex, either the l-alkaloid-l-cobalt complex or d-alkaloid-d-cobalt complex was always found to separate out as the least soluble fraction, while either the l-alkaloid-d-cobalt complex or d-alkaloid-l-cobalt complex always contituted the most easily soluble fraction. 3. The specific rotations of potassium and ammonium diammine-dinitro-oxalo-cobaltiates, which have been obtained by replacing the alkaloid molecules with potassium-and ammonium ions respectively, were measured, and found to have the values of ca±115°, using sodium light. 4. As a results of the mesotomisation of diammine-dinitro-oxalo-cobalt complex, the configurations of this complex and also of its mother substance, diammine-tetranitro-cobalt complex, have been made clear, the possibility of mesotomisation indicating that the complex ion [Co(NH2)2(NO2)2C2O4] is constructed asymmetrically, which means that the two ammonia molecules in this complex ion occupy the adjacent spacial position. As to the two nitro-groups, their position was previously determined, by one of the authors (Shibata), by a spectroscopic study. 5. The molecular asymmetry of the above mentioned complex ion, which is the first example of a mesotomised complex anion containing a cobalt atom, belongs to a new type and has been introduced into the stereochemistry of the metal complexes, calling it the type of molecular asymmetry III, in extension of Werner\u27s classification. The senior author, Yuji Shibata, has profound sorrow in recording here the death of his collaborator Mr. Toshio Maruki, Rigakushi, which occurred during the progress of the investigation recorded in this paper. At the same time, he has much pleasure in expressing his hearty thanks to Messrs. K. Matsuno, Rigakushi, and S. Mitsukuri for the great assistance they have given him in completing this work

    Depth sequence distribution and reactivity of phosphorus in intensively managed agricultural soils in East-Central Illinois

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    This Thesis was approved for publication on 2019-04-08 at 15:57.DSpace SAF Submission Ingestion Package generated from Vireo submission #13519 on 2019-08-22 at 16:20:52Made available in DSpace on 2019-08-23T20:44:40Z (GMT). No. of bitstreams: 2 XU-THESIS-2019.pdf: 2814010 bytes, checksum: 7ebbd7fa8d0cf8f58df6fd38672b297c (MD5) LICENSE.txt: 4205 bytes, checksum: 24279c1023adaecdec24b371e5bec881 (MD5) Previous issue date: 2019-04-08Embargo set by: Seth Robbins for item 112286 Lift date: 2021-08-23T20:44:50Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemSubsurface loss of phosphorus (P) in agricultural soils in the Midwestern U.S. has been receiving attention in the last few decades because of its negative environmental impacts to aquatic ecosystems such as eutrophication and hypoxia. Thus, there is a great interest in understanding the distribution and reactivity of P in the soils influencing the subsurface P loss. In this study, the depth sequence distribution, speciation, reactivity of P, and soil physicochemical properties were investigated in intensively managed agricultural soils in East-Central Illinois using chemical extraction/digestion, batch desorption experiments, infiltrometer measurements, Nuclear Magnetic Resonance spectroscopy, and X-ray diffraction analysis. The results suggested several sources of P contributing to subsurface P loss. During the growing season when the water table is low, calcium P (Ca-P: P adsorbed by calcite/dolomite and/or apatites) in subsoils is likely to be the main source of labile P (>70% of total inorganic phosphorus (IP) in subsoils). Both P desorption from calcite/dolomite and dissolution of Ca-P precipitates contribute to the concentration of labile P in subsoils. Although the amount of other IP species such as Fe-occluded P and non-occluded P was low, P desorption from amorphous Fe oxyhydroxides should not be excluded. During the wet spring season, surface soils becomes an additional source of P. In surface soils, Ca-P was a major IP species (~40-70% of total IP in topsoils) followed by non-occluded P (9-40% of total IP in topsoils) and Fe-occluded P (6-30% of total IP in topsoils). The labile P via dissolution and/or desorption of these IP pools and mineralized organic P in the surface soils can be translocated to tile lines through preferential flow paths. All of these findings should help the Illinois Nutrient Reduction Strategy Plan to develop the strategy to reduce the agricultural nutrient loss to Illinois waters and the Gulf of Mexico.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2021-05-01The student, Suwei Xu, accepted the attached license on 2019-04-08 at 14:17.The student, Suwei Xu, submitted this Thesis for approval on 2019-04-08 at 14:34.Embargo set by: Seth Robbins for item 112286 Lift date: 2021-08-23T20:46:41Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 112286 Lift date: 2021-08-23T20:47:38Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 112286 Lift date: 2021-08-23T20:48:32Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemLimited Restriction Lifted for Item 112286 on 2021-08-24T09:15:31Z
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