1,720,973 research outputs found
Nodal mature plasmacytoid dendritic cell proliferation mimicking lymphoma in a patient with CALR-mutated myelofibrosis
No full textRenal cell carcinoma metastatic to a pituitary FSH/LH adenoma: Case report and review of the literature
Full text linkMetastases to the pituitary occur more frequently in patients with widespread cancer and mainly involve the posterior lobe. A few cases of metastatic carcinoma to a pituitary adenoma have been described so far. Here, the authors present an additional case of a clear cell renal cell carcinoma (CCRCC) metastatic to a FSH/LH/α-subunit pituitary adenoma and systematically review the literature. Immunohistochemistry and electron microscopy were performed to characterize both neoplastic components at the morphological level. Moreover, it was hypothesized that expression of VEGF and of the corresponding receptor VEGFR1 could be implicated in the development of the carcinomatous metastasis within the adenoma
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
The spectrum of lymphoproliferative disorders in endocrine organs: from histology to molecular genetics
No full textLymphoproliferative disorders (LPDs) rarely involve the endocrine system, either as dissemination of a systemic condition, or as primary diseases. Due to their rarity, LPDs of endocrine organs can represent a diagnostic challenge for both pathologists and clinicians. Nevertheless, a comprehensive review of LPDs arising in endocrine organs reveals several specific clinico-pathological features that can be helpful in the correct management of the cases, from both a diagnostic and a therapeutic point of view. We designed this review with the aim of systematically addressing the morphological, immunohistochemical and genetic characteristic of LPDs of the different endocrine organs. Both lymphomas and mass forming immune cell-based inflammatory diseases, such as IgG4-related lesions, are included in the discussion. In addition, for each primary site, we propose a step-wise diagnostic approach and provide the reader with practical tools to address differential diagnostic and prognostic issues that can be useful to manage such unexpected lesions in daily practice. Finally, endocrine function in lymphoma is discussed
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Fatal Splenic Rupture in a Previously Undiagnosed Multiple Myeloma: Morphological, Immunophenotypical and Molecular Cytogenetic Analyses
No full textPathological rupture of the spleen in uncomplicated multiple myeloma is an extremely rare phenomenon, which has been reported only in 2 cases. In our patient, the massive liver and spleen infiltration led to a situation in which bleeding diathesis and mechanical stress can be assumed as the causative factors of the spleen rupture. Thus, the marked propensity to extramedullary infiltration of myeloma cells in this case seems to be responsible for the unfortunate outcome of the patient. The results of the immunophenotypical and genetic analysis of these myeloma samples suggest that events affecting cell relationships with the microenvironment might be related to the ability of neoplastic cells to grow outside bone marrow and to infiltrate extramedullary organs. Multiple myeloma is usually considered a slowly progressing disease with a long natural history. The case we reported, with its sudden and fatal outcome, highlights the importance of the clinical evaluation of extramedullary localization of the disease. Further studies are needed to evaluate the role of molecular alterations of cell cycle progression and microenvironment interactions with the aim of identifying possible therapeutic targets
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