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Activity of a synthetic microbicidal peptide against Influenza A virus multiplication
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Activity of a synthetic microbicidal peptide against Influenza A virus multiplication
Conti G., Magliani V., Portincasa P., Conti S., Polonelli L.
Department of Pathology and Laboratory Medicine- Microbiology Section - University of Parma
A killer peptide (KP) engineered from the sequence of the variable region of a recombinant antiidiotypic antibody
representing the internal image of a killer toxin, is characterized by the wide spectrum of microbicidal activity against
pathogenic eukaryotic and prokaryotic microrganisms.
Based on the surprising sequence homology of KP with the light chain variable region of an antibody (HC63) that
prevents the haemagglutinin, HA, low pH fusogenic transition of Influenza A virus, we report the “in vitro” inhibition
of Influenza A virus multiplication in LLC-MK2 cells which is mediated by a marked reduction of glycosylation of HA,
as well as its synthesis.
The restriction of the production of mature virion particles could be the result of a defect involving the migration and /
or the association - insertion of virus haemagglutinin HA into the plasma membrane of infected LLC-MK2 cells treated
with KP.
Moreover, this hypothesis is also in good agreement with the haemadsorption as well as immunoprecipitation
experiment results
Rotture intraoperatorie delle arterie intracraniche: riparazione mediante clips cilindriche in Silastic (Ishiwata)
No full textRotture intraoperatorie delle arterie intracraniche: riparazione mediante clips cilindriche in Silastic (Ishiwata)
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Trattamento radicale, mediante approccio microchirurgico e radiochirurgia stereotattica di MAV gigante talamo striata sinistra
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Direct microsurgical approach of giant intracranial aneurysms: consideration, technical notes, and results in a series of 50 cases
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MAV ponto-mesencefalica manifestantesi con sindrome da espanso: regressione della sintomatologia dopo exeresi completa
No full textDirect microsurgical approach of giant intracranial aneurysms: cosiderations, technical, notes and results in a series of 50 cases
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