1,723,110 research outputs found
Comment on: "Prognostic value of preoperative albumin to globulin ratio in patients treated with salvage radical prostatectomy for radiation recurrent prostate cancer"
No full textDeterminazione delle logiche di controllo per trasmissioni con cambi meccanici robotizzati
No full textLe conoscenze giovanili sulle radiazioni ionizzanti. Intervento e valutazione nelle scuole superiori del Lazio
No full textHAP1 loss in L-asparaginase resistance
No full textIn this issue of Blood, Lee et al identify huntingtin associated protein 1 (HAP1) loss as
a new marker of L-asparaginase resistance in acute lymphoblastic leukemia (ALL)
and provide evidence for the pathway involved. They discovered that HAP1 is
essential for the formation of the ternary complex with huntingtin (Htt) and inositol
1,4,5-triphosphate receptor (InsP3R) and that its loss impairs the L-asparaginase–
mediated increase of cytosolic Ca21 needed for triggering apoptosis (see figure). Their
data were confirmed by specific knockdown of HAP1 in SEM cells and by measurement
of both endoplasmic reticulum–released Ca21 and external Ca21 influx.
Intersectoral default contagion: A multivariate Poisson autoregression analysis
Full text linkThis paper analyzes credit rating default dependencies in a multisectoral framework. Using Mergent's FISD database, we study the default series in the U.S. over the last two decades, disaggregating defaults by industry-sector group. During this period, two main waves of default occurred: the implosion of the “dot-com” bubble and the global financial crisis. We estimate a Multivariate Autoregressive Conditional Poisson model according to the biweekly number of defaults that occurred in different sectors of the economy from 1996 to 2015. We discuss the contagion effect between sectors in two ways: the degree of transmission of the probability of default from one sector to another, i.e., the “infectivity” of the sector, and the degree of contagion of one sector from another, i.e., the “vulnerability” of the sector. Our results show differences between the sectors' relations during the first and second part of our sample. We add some exogenous variables to the analysis and evaluate their contribution to the goodness of fit
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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