875 research outputs found
Roger and Carol V. Thompson Sheldon
No full textDr. Roger Sheldon ‘64 is a graduate of Illinois Wesleyan University and Northwestern University Feinberg School of Medicine. His postgraduate training included a residency in pediatrics in Boston and fellowships in pediatric pulmonology and neonatal-perinatal medicine in Denver. Joining the CU faculty in 1976, he established one of the nation’s first neonatal nurse practitioner programs at St. Joseph Hospital in Denver and later led the neonatal section and NICU at the University of Oklahoma before serving 21 years as assistant dean for Continuing Medical Education. Additionally, he served as both assistant medical director of Heartland Health Plan and medical director of the Children’s Hospital of Oklahoma. During his Wesleyan years, Dr. Sheldon was president of the Student Senate, as well as a member of the marching band, the Collegiate Choir, the Apollo Quartet, Blue Key, and Phi Kappa Phi. Since retirement, Roger has devoted time to child advocacy, the American Academy of Pediatrics, the Earl E. Bakken Medical Devices Center at the University of Minnesota, and Doctors for Early Childhood. Dr. Sheldon and his wife of 57 years, Dr. Carol V. Thompson Sheldon, have two children and six grandchildren. Son Christopher Sheldon is a history, theater, and speech teacher in Massachusetts, and daughter Dr. Rebecca Ansari is a retired emergency physician and an author in Minnesota. Dr. Sheldon’s brother, Mark Sheldon ‘70, was Student Senate president during his time at Wesleyan, and their mother and father, Helen McNicol Sheldon ’40 and Chet Sheldon ‘43, won the IWU Alumni Loyalty Award in 2009. Dr. Sheldon attended his first IWU class at three or four weeks of age in a bassinet carried by his father.
Dr. Carol V. Thompson Sheldon \u2765 graduated from Illinois Wesleyan University in 1965 with a BS in mathematics. During her Wesleyan years, Dr. Sheldon served as Kappa Kappa Gamma scholarship chairman and vice president, IWU Dad’s Day chairman, and Student Senate secretary. She was a member of Beta Beta Beta, Alpha Lambda Delta, Green Medallion, Egas, and Phi Kappa Phi honor societies. After college, Carol worked in computer programming and systems analysis at Chicago’s Illinois Bell Telephone and then at Boston Children’s Hospital. She tutored an immigrant child for Hull House in Chicago and was foster mother to five-year-old Joey in Boston. Dr. Sheldon never gave up her dream of becoming a physician and in 1979, after having two children, she received her MD degree from the University of Colorado. In 1983 she completed a residency in diagnostic radiology from the University of Oklahoma. Dr. Sheldon was the first woman to chair the Radiology Department and the first woman to serve as President of the Central Oklahoma Radiological Society. In 1998 she subspecialized in breast diagnosis, first at the University of Oklahoma College of Medicine, and then working with two other women to cofound Breast Imaging of Oklahoma, where she practiced until her retirement in 2010. Since retirement and a move to Minneapolis, Dr. Sheldon has served as president of the Minneapolis branch of the American Association of University Women, a chapter of roughly 350 members. The group’s mission is equity for women and girls, supporting college scholarships to nine Minneapolis High School graduates each year, as well as providing food, clothing, and transitional housing to surrounding neighborhoods.https://digitalcommons.iwu.edu/awards_distinguished/1096/thumbnail.jp
THE OBSESSION OF CONTROL IN THE CHARACTER “EVE BLACKWELL” IN SIDNEY SHELDON’S MASTER OF THE GAME
No full textDalam suatu kelompok masyarakat, terdapat berbagai jenis kepribadian. Meskipun mereka hidup secara berdampingan dalam lingkungan yang sama, kemungkinan akan terjadinya konflik sangatlah terbuka lebar. Dalam skripsi ini, penulis membahas jenis kepribadian narsisistik, konflik – konflik yang dihadapi. dengan orang – orang disekitarnya maupun dengan dirinya sendiri, serta berakhirnya obsesi untuk pengendalian dari tokoh bernama Eve Blackwell dalam novel berjudul Master of the Game karya Sidney Sheldon. Keinginan si tokoh untuk memenangkan perhatian sang nenek dari saudari kembarnya berkembang menjadi keinginan akan kepuasan lahir dan batin dengan mengendalikan orang – orang disekitarnya termasuk dalam hubungan seks. Tujuan penulisan skripsi ini adalah untuk memaparkan usaha – usaha Eve Blackwell, dalam novel Master of the Game karya Sidney Sheldon, untuk mengendalikan orang – orang disekitarnya, konflik – konflik yang dihadapinya dan juga akhir dari obsesi akan kendalinya.
Untuk menganalisis tokoh ini, penulis menggunakan metode pendekatan struktural dan psikologis dengan menggabungkan teori narsisisme dari Joanna M. Ashmun dan teori obsesi dari S. Rachman. Penulis mengumpulkan data – data yang dibutuhkan dengan menggunakan metode penelitian pustaka.
Setelah melakukan analisis yang ditunjang oleh data - data, kita dapat mengetahui bahwa orang berkepribadian narsisistik seperti tokoh Eve Blackwell , yang kekuatan utamanya ada pada parasnya yang cantik, dapat menghalalkan segala cara untuk mewujudkan keinginannya. Namun dalam usaha – usahanya tersebut muncul berbagai bentuk perlawanan yang akan berujung pada konflik, baik internal maupun eksternal. Di bagian akhir analisis, kita juga dapat mengetahui bahwa dominasi orang berkepribadian narsisistik dapat dihentikan oleh kemunculan orang yang tepat seperti Keith Webster, yang berprofesi sebagai dokter operasi plastik, di waktu yang tepat
Effects of adenosine on pressure-flow relationships in an in vitro model of compartment syndrome
No full text Shrier, Ian, Ari Baratz, and Sheldon Magder. Effects of adenosine on pressure-flow relationships in an in vitro model of compartment syndrome. J. Appl. Physiol. 82(3): 755–759, 1997.—Blood flow through skeletal muscle is best modeled with a vascular waterfall at the arteriolar level. Under these conditions, flow is determined by the difference between perfusion pressure (Pper) and the waterfall pressure (Pcrit), divided by the arterial resistance (Ra). By pump perfusing an isolated canine gastrocnemius muscle ( n = 6) after it was placed within an airtight box, with and without adenosine infusion, we observed an interaction between the pressure surrounding a muscle (as occurs in compartment syndrome) and baseline vascular tone. We titrated adenosine concentration to double baseline flow. We measured Pcrit and Ra at box pressures (Pbox), which resulted in 100 (Pbox = 0), 90, 75, and 50% flow without adenosine; and 200, 180, 150, 100, and 50% flow with adenosine. Without adenosine, each 10% decline in flow was associated with a 5.7 mmHg increase in Pcrit ( P < 0.01). With adenosine, the same decrease in flow was associated with a 2.6-mmHg increase in Pcrit ( P < 0.01). Values of Pcrit at 50% of flow were almost identical. Each 10% decrease in flow was also associated with 2.2% increase in Ra with or without adenosine ( P < 0.001). Ra decreased with adenosine infusion ( P < 0.05), and there was no interaction between adenosine and flow ( P > 0.9). We conclude that increases in pressure surrounding a muscle limit flow primarily through changes in Pcrit with and without adenosine-induced vasodilation. The interaction between Pbox and adenosine with respect to Pcrit but not Ra suggests that Pbox affects the tone of the vessels responsible for Pcrit but not Ra. </jats:p
Sheldon and Co's Modern School Third Reader.
No full textTwo fables find their way into this little book: The Lark and Her Young (47) and Trying to Please Everybody (MSA, 73). The latter has a distinctive and lively illustration. This book is in terrible condition: one missing and many torn pages, foxing, a weak binding, and coloring all help to keep its value down! There are strong engravings of children in this book. Some child has written on 238: Do let me sleep ! The binding now exposed shows a fascinating use of a small iron bar, heavy mesh, and nails.This is a hardbound book (hard cover)After Artzybasheff and Sir Robert [sic] L'Estrang
René Géronimo Favaloro : pioneer of Cardiac Surgery
No full textDr. René G. Favaloro moved to the Cleveland Clinic in 1962 and proceeded to reshape the face of cardiac surgery as we knew it. Together with his colleagues at the Cleveland Clinic, Drs. Effler, Sones, Proudfit, Groves, Sheldon and countless others, he contributed to the double internal mammary arterymyocardial implantation by the Vineberg method, and by May 1967, he reconstructed the right coronary artery by the saphenous vein graft interposition. These landmark procedures paved the way for the aorto-coronary saphenous vein bypass graft in October 1967. Many similar breakthroughs ensued, with the application of the bypass technique to the left coronary artery, the combination of coronary artery bypass graft with left ventricular reconstruction and valve repair/replacement and finally, by December, a double bypass to the right coronary artery and anterior descending branch of the left coronary artery. In June, 1971, Dr. Favaloro decided to leave the Cleveland Clinic and return to Argentina where he created a medical centre, a teaching unit, a research department and finally an Institute of Cardiology and Cardiovascular Surgery. This was his greatest personal ambition. Over and above his brilliant mind and craft, Dr. Favaloro was a man of integrity, courage, honesty and humility, whose name will never cease to reverberate throughout the history of medicine.peer-reviewe
Critical closing pressures, vascular waterfalls, and the control of blood flow to the hindlimb
No full textNote:Pressure- flow relations in the hindlimb are best explained by a model which incorporates a vascular waterfall at the level of the arterioles. The mechanisms controlling the critical pressure at the waterfall (P crit) and arterial resistance (~) were examined in the canine hindlimb. Lowering carotid sinus pressure (Pear) caused both P crit and Ra to increase (neural response). Increases in local perfusion pressure (P per) caused P crit to increase (predominantly a myogenic response), but Ra to decrease (predominately a passive or flow-mediated response). When tone was increased by blocking the synthesis of endothelium-derived relaxing factor or through a1 - activation, the myogenic response of P crit increased and the decrease in Ra with increasing P per was abolished. The myogenic response of P crit was not eliminated with a calcium-channel blocker, nor when reactive hyperemia was abolished with maximal vasodilation. However, maximal vasodilation lowered P crit below the downstream pressure, thereby eliminating waterfall behaviour during normal flow. These findings suggest that P crit and Ra are dependent on the interaction of several different control systems.C'est le modelé intégrant une cascade de réactions vasculaires au niveau des artérioles qui peut le mieux rendre compte des relations entre la pression et le débit dans les membres antérieurs. Les mécanismes qui contrôlent la pression critique au point de cascade P crit et la résistance arterielle (Ra ) ont été étudies dans les membres antérieurs de chiens. L'abaissement de la pression du sinus carotidien (P car) a entrainé une augmentation de P crit et de Ra (réponse neurale). L'augmentation de la pression locale a provoqué l'augmentation de P Crit (réponse avant tout myogénique), mais un abaissement de Ra (réponse avant tout passive ou à médiation par le débit). L'augmentation de tonus par blocage de la synthèse du facteur de relaxation dérive de l'endothélium ou par activation a1 a provoqué l'augmentation de la réaction myogénique de P Crit et l'abaissement de Ra , qui est fonction de l'augmentation de P per, a été supprimé. L'administration d'un inhibiteur des voies du calcium n'a pas supprime la réaction myogénique de P Crit non plus que la vasodilatation maximale n'a fait disparaitre l'hyperémie réactive. Toutefois, la vasodilatation maximale a abaisse P crit sous la pression en aval, supprimant ainsi le phénomène de cascade pendant le débit normal. Ces résultats semblent indiquer que P crit et RA dépendent de 1 'interaction de plusieurs systèmes de contrôle distincts
Endothelial dependent dilation by estrogen through the AKTPKB pathway
No full textAcute administration of estrogen results in the vasodilatation and in the release of nitric oxide (NO) that occurs through activation of the serine-threonine kinase Akt/protein-kinase-B (PKB), which is known to increase the eNOS activity. 10-8 M of 17-beta-estradiol resulted in a left shift of the vasodilatory response to Ach in preconstricted aortic rings from oophorectomized rats (EC50 = 0.7 x 10-8 M with 17-beta-estradiol and 0.15 x 10-7 M of Ach without 17-beta-estradiol, P < 0.05). The effect was blocked by pre-treatment with Wortmannin, a PI(3)K inhibitor. AKT/PKB was phosphorylated in endothelial cells (EC) as early as 1-minute after estradiol-stimulation. Phosphorylation of eNOS and NO release in EC treated with 17-beta-estradiol were also increased. We conclude that the AKT/PKB pathway is involved in the acute release of NO by estrogen
Role of nitric oxide and its interaction with superoxide in porcine model of septic shock
No full textAlthough nitric oxide (NO) from inducible nitric oxide synthase (NOSII) is proposed to be the major factor in the vascular abnormalities of sepsis in rats, its role in higher order species is not well established. This thesis thus, addresses the role of NO in septic pigs.I first hypothesized that induction of NOSII in pigs is the cause of sepsis-induced hypotension as occurs in rodents. To test this, I treated pigs with lipopolysaccharide (LPS) to simulate sepsis. In contrast to what is observed in rats and mice, plasma nitrite did not change during the 4 hours of the LPS infusion and there was no increase in calcium (Ca)-independent nitric oxide synthase (NOS) activity in lung tissue from endotoxemic pigs compared to control animals. Furthermore, there was only minimal induction of NOSII mRNA.My second hypothesis was that NOS (NOSIII) is not down regulated in septic pigs, and NO from NOSIII, could contribute to peroxynitrite formation. In support of this, western blot analysis of samples from aorta and vena cava showed no down regulation of NOSIII. There also was an increase in Ca ++-dependent NOS activity of aorta and vena cava after 2-hour of endotoxemia, which indicates increased constitutive NOS activity. Moreover, there was an increase in NOSI in the vena cava. LPS produced a leftward shift in the dose-response curves of SVR and RVR in response to the NOS inhibitor, L-NAME (NG -nitro-L-arginine-methyl-ester).Peroxynitrite is formed from NO and superoxide (O2 -). Since NO was not increased in endotoxemic pigs, I next hypothesized that O2- is increased in endotoxemic pigs and this reacts with NO from constitutive NOS to form peroxynitrite. To test this hypothesis, I first studied rats to confirm that O2 - is increased in arterial vessels of endotoxic rats. There was a small increase in basal O2- in endotoxic rats. Stimulation of NAD(P)H oxidase by giving the substrate, NADH, did not result in different O2- production in control and endotoxic rats. However, inhibition of NOS increased O2 - in endotoxic rats.I demonstrated by immunohistochemistry and western blot analysis, that the components of NAD(P)H oxidase, gp91phox, p22phox , and p47phox are present in skeletal muscle and it has similar behavior to other non-phagocytic NADPH oxidases. The addition of L-NAME to NADH-treated diaphragm strips of endotoxic rats, increased O 2- production in endotoxic rats indicating that O2- production counters the increased NO formation as we observed in rat aorta. These observations indicate that O2 - generation from NADPH oxidase in skeletal muscles can play a role in the pathophysiology of sepsis. (Abstract shortened by UMI.
Peripheral vs central control of cardiac output
No full textNeural, humoral and mechanical factors affecting cardiac function and the peripheral vasculature were examined to assess the relative importance of peripheral vs cardiac factors in the control of cardiac output during exercise. First, I examined neural vs local regulation of humoral vasoconstrictors endothelin-1 (ET) and NPY, in anesthetized dogs, and showed that plasma ET levels, in contrast to NPY, increase in response to systemic hypotension but not carotid sinus baroreceptor activation. This did not occur with intact vagi suggesting an interaction of neural and humoral factors. In the next two studies I separated peripheral vascular and cardiac neural influences on cardiac output (CO) and right atrial pressure (Pra) responses during graded exercise by comparing cardiac denervated heart transplant patients (HT) with normally innervated subjects. The increase in Pra was higher in HT than normals but stabilized as the CO increased at peak effort. Stimulation of the heart with dobutamine in 2 patients did not increase exercise capacity, suggesting that peripheral not cardiac factors limit exercise in HT patients. The rise in central venous pressure at exercise onset was similar in both groups which demonstrates the importance of the mechanical effect of muscle contraction vs reflex changes in mobilizing blood from the peripheral vasculature at exercise onset. In the fourth study I assessed whether large changes in human body mass, induced by isolated gastric bypass surgery, would affect the heart rate (HR)/oxygen consumption (VO2) relationship during exercise. Peak absolute VO2 was significantly lower in the previously obese group vs obese and control groups despite similar normalized 24-hour energy expenditure. HR was higher in the previously obese at a given submaximal VO2 due to the higher relative VO2, suggesting a significant loss of muscle mass and supporting the idea that HR is a function of the relative VO2. In the fifth study I assessed the influence o
Universal Probability Distribution for the Wave Function of a Quantum System Entangled with Its Environment
No full textA quantum system (with Hilbert space H1) entangled with its environment (with Hilbert space H2) is usually not attributed a wave function but only a reduced density matrix ρ1. Nevertheless, there is a precise way of attributing to it a random wave function ψ1, called its conditional wave function, whose probability distribution μ1 depends on the entangled wave function ψ∈H1⊗H2 in the Hilbert space of system and environment together. It also depends on a choice of orthonormal basis of H2 but in relevant cases, as we show, not very much. We prove several universality (or typicality) results about μ1, e.g., that if the environment is sufficiently large then for every orthonormal basis of H2, most entangled states ψ with given reduced density matrix ρ1 are such that μ1 is close to one of the so-called GAP (Gaussian adjusted projected) measures, GAP(ρ1). We also show that, for most entangled states ψ from a microcanonical subspace (spanned by the eigenvectors of the Hamiltonian with energies in a narrow interval [E,E+δE]) and most orthonormal bases of H2, μ1 is close to GAP(tr2ρmc) with ρmc the normalized projection to the microcanonical subspace. In particular, if the coupling between the system and the environment is weak, then μ1 is close to GAP(ρβ) with ρβ the canonical density matrix on H1 at inverse temperature β=β(E). This provides the mathematical justification of our claim in [J. Statist. Phys. 125:1193 (2006), http://arxiv.org/abs/quant-ph/0309021] that GAP measures describe the thermal equilibrium distribution of the wave function.Peer reviewe
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