163,259 research outputs found

    Melanoma-associated adhesion molecule MUC18/MCAM (CD146) and transcriptional regulator Mader in normal human CNS

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    The proteins MUC18 and Mader have been identified as markers of tumor progression in melanoma cells, MUC18, also known as MCAM (melanoma cell adhesion molecule) and as CD146 (endothelial antigen), is a cell adhesion molecule belonging to the immunoglobulin superfamily, Mader is a transcriptional regulator shown to negatively regulate EGR-1. As it is known that neoplastic cells of neuroectodermal origin frequently express neuron-specific molecules, we studied whether these melanoma-associated antigens are found in normal CNS tissue. We investigated the expression of MUC18/MCAM and Mader in adult human post mortem CNS tissue by immunohistochemistry, immunoblot and two-dimensional gel electrophoresis. Our results show that Mader is preferentially expressed on neurons and glial cells and that the adhesion protein MUC18/MCAM is mainly expressed on vasculature within the CNS. These observations may have important implications for further studies investigating their possible roles in cell adhesion and proliferation control within the CNS

    Die Schlacht bei Tanga : Erzählung aus dem Weltkrieg

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    von Fr. W. Mader ; mit Zeichnungen von Karl MühlmeisterSchriftenreihe des Originals: Spannende Geschichten ; 3

    Henry William Mader, (1863-1943), purchased by Mr. Elmer W. Hinkleman on May 14, 1945.

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    Documents regarding the headstone for Henry William Mader, (1863-1943), purchased by Mr. Elmer W. Hinkleman. The marker was placed at Memorial Park Cemetery, Lot 103, Section 1 in Sylvania, Ohio. The stone is made of Rock of Ages with Polished Flat Top Balance Rock in Sandblast letters

    Der Markt für Hedgefonds-Zertifikate in Deutschland

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    Der Markt für Hedgefonds-Zertifikate in Deutschland / W. Mader, C. Echter. - In: FinanzBetrieb. 6. 2004. S. 612-61

    Basel II - Mindestkapitalanforderungen: Alternativen bei der Unterlegung von Verbriefungen

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    Basel II - Mindestkapitalanforderungen: Alternativen bei der Unterlegung von Verbriefungen / W. Mader, C. Miehle. - In: Zeitschrift für das gesamte Kreditwesen. 59. 2006. S. 232-24

    Prof. Th. W. Adorno and the author Hans Erich Nossack.

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    Prof. Th. W. Adorno and the author Hans Erich Nossack at a reception of Insel Verlag, Buchmesse Frankfurt 1966LB

    Susan Mader and Eric Ripley at First Secularized Board of Governors Meeting, 1970

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    b&w photographExcellent condition: curling a bit, on back: 'to 29 1/2 picas', and on bottom border, 'Members of new board, page 4 82% Journal'.Board members Lawrence Hayes (left, of Halifax law firm McInnes, Cooper & Robertson), Susan Mader (Arts class of 1971, SRC Secretary), and Eric Ripley (Science class of 1970, SRC Science rep, with mutton chop whiskers!) stand talking during Saint Mary's first secularized Board of Governors meeting.Susan Mader was the first woman to sit on the Board

    Epilachna ocellataemaculata Mader 1930

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    Epilachna ocellataemaculata (Mader, 1930) (Figs. 16 a–h) Specimens examined. Hubei: Shennongjia Net Res, 1998.vi. 1–5, Bolm (1, NHMB). Yunna: Yulongshan, Baishui, 1990.vii. 7–12, D. Král (1, NHMB); Lijiang, 1990.vi. 30 –vii. 2, Lad. Bocák (10, NHMB); Kunming, Western Hills, 1990.vii. 9, Lad. Bocák (5, NHMB); Xishan, 1993.vi. 27, Bolm (1, NHMB); Dongchuan, 1994.vi. 28 –vii. 3, Vit Kubáň (1, NHMB). Sichuan: Moxi, Hailuogou, 1994.vii. 1–7, J. Farkač & D. Král (3, NHMB). Guizhou: Leigongshan, 1983.vii. 13–15, Chen Zhenyao (2, SYSM); Daozhen, Sanqiaozhen, 2004.v. 22–24; Dashanhe, 2004.v. 29–31, Song Qiongzhang (2, SYSM). Remarks. Male genitalia of E. ocellataemaculata and E. plicata are almost identical (Figs. 16, 17) but both species can easily be distinguished externally by a peculiar elytral color pattern (Figs. 16 a, 17 a) and subapical ‘plica” in E. plicata (Fig. 17 b).Published as part of Pang, Hong, Ślipiński, Adam, U, Yap Ing W & Zuo, Yongsheng, 2012, Contribution to the knowledge of Chinese Epilachna Chevrolat with descriptions of new species (Coleoptera: Coccinellidae: Epilachnini), pp. 1-37 in Zootaxa 3420 (1) on pages 20-21, DOI: 10.11646/zootaxa.3420.1.1, http://zenodo.org/record/28196

    Critical vertices in k-connected digraphs

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    It is proved that every non-complete, finite digraph of connectivity number k has a fragment F containing at most k critical vertices. The following result is a direct consequence: every k-connected, finite digraph D of minimum out- and indegree at least 2k+m−1 for positive integers k, m has a subdigraph H of minimum outdegree or minimum indegree at least m−1 such that D−x is k-connected for all x∈V(H). For m=1, this implies immediately the existence of a vertex of indegree or outdegree less than 2k in a k-critical, finite digraph, which was proved in Mader (J Comb Theory (B) 53:260–272, 1991). The final publication is available at Springer via https://doi.org/10.1007/s12188-016-0173-y

    Nowe spojrzenie na planowanie architektury mieszkaniowej w afryce subsaharyjskiej

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    The author shares his reflections on state of art in housing and urban planning, deficiencies, expectations and possibilities in the Sahel region of Africa. He notices, that the housing problem in Africa is one of the challenges, which should be solved in order to recover life dignity of African people and secure their rights to traditional family life in acceptable conditions. The paper describes the studies on the typical dispersed urban structures and the need to foster this type of settlement structure and proposals of introduction of new on light steel frame housing system in the area of Sahel, combining the traditional way of building houses with modern technology. The particularly analysed case, is the housing problem in the Republic of Chad. The author presents the basic discussion on this topic and his architectural proposals. Unfortunately, the gap between the needs and the financial feasibility of housing construction in this area, makes this project already at the starting point extremely difficult to be realized without external subventions.Problem mieszkaniowy w Afryce jest jednym z wyzwań, które należy rozwiązać, aby Afrykanie mogli odzyskać godność życiową i zabezpieczyć swoje prawa do tradycyjnego życia rodzinnego w akceptowalnych warunkach. W artykule opisano badania nad typowymi rozproszonymi strukturami miejskimi i potrzebą wspierania tego typu struktur osadniczych oraz propozycji wprowadzenia nowego systemu konstrukcji domów, opartym na lekkim szkielecie stalowym, łączącym tradycyjny sposób budowania domów z nowoczesną technologią. Przypadkiem szczególnie analizowanym jest problem mieszkaniowy w Republice Czadu. Autor przedstawia podstawową dyskusję na ten temat i swoje propozycje architektoniczne. Niestety luka między potrzebami mieszkaniowymi w Czadzie a finansową wykonalnością budownictwa mieszkaniowego w tym obszarze sprawia, że projekt ten, już w punkcie wyjścia, jest niezwykle trudny do realizacji bez uzyskania zewnętrznych dotacji
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