6,697 research outputs found
A rational approach to Pi, Notes of a lecture held on the occasion of Pi-day on July 5, 2000 in Leiden
No full textThis article is based on notes for the lecture with the same title, which was held by the author on the occasion of the `Pi in de Pieterskerk' event (Pi-day) on July 5, 2000. The present article expands these notes with short proofs of most of the theorems given, but not proved, during the lecture
"I' ll tell you a story that will make you believe" in narratives: the role of metafiction in the novel and in the film Life of Pi
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Inglês: Estudos Linguísticos e Literários, Florianópolis, 2015.Recentes estudos propõem que adaptações cinematográficas sejam entendidas como fonte de criação, os quais refletem contextos e interpretações diferentes do texto em que são baseadas. Nessa dissertação, propõe-se uma análise comparativa do romance Life of Pi (2001), de Yann Martel e do filme homônimo dirigido por Ang Lee (2012). A análise tem como objetivo identificar a presença e o modo em que a metaficção é construída no romance e no filme, e quais são alguns significados produzidos por ela em ambos os textos, tanto o literário quanto o fílmico. A concepção de metafição se baseia nas definições de Linda Hutcheon e Patricia Waugh. Por metaficção, entende-se a ficção consciente de si, que expõe o processo de escrita ao leitor e o convida a ter um papel ativo na construção do significado. Após uma análise comparativa dos dois textos, conclui-se que a metaficção está presente em ambos, tanto tematicamente como estruturalmente. As reflexões sobre narrativas apresentadas pelos personagens, o uso de vários níveis narrativos e de intertextualidade revelam diferentes usos da metafição em ambos. A diferença mais importante entre o romance e o filme Life of Pi está no uso dos níveis narrativos. Enquanto o romance possui um ?autor? sem nome que apresenta a história aos leitores, o filme possui um diretor implícito que deixa pistas de qual versão da história de Pi é ?real? no contexto da narrativa. Essa diferença dá ao romance um final aberto, em que o leitor deve escolher qual versão da história ele acredita, enquanto o filme possui uma resolução para essa questão. O filme, então, pode ser entendido como um testemunho, uma narrativa de trauma de um sobrevivente de um naufrágio e da experiência de migração, enquanto o livro não apresenta uma decisão em relação às versões da história, deixando o leitor aberto a qualquer possibilidade.Abstract : Recent studies propose that Film Adaptations should be understood as sources of creation, which also reflect a different context and interpretation from the text upon which they were based. In this thesis, I propose a comparative analysis of the novel Life of Pi (2001), by Yann Martel, and the homonymous film directed by Ang Lee (2012). The analysis has the objective of identifying the presence and the way in which metafiction is constructed in the novel and in the film, and what are some of the meanings produced by it in both texts, the filmic and the literary. The concept of metafiction was based on the definitions by Linda Hutcheon and Patricia Waugh. It is understood as the self-conscious fictional text, which exposes the writing process to the readers and invites them to have an active role in the construction of meaning. In the comparative analyses of the two texts, I have proved that metafiction is present in the two texts, both thematically and structurally. The reflections of the characters on narrative itself as well as the use of different narrative levels and intertextual references reveal different uses of metanarrative in both film and novel. The most important difference between the novel and the film Life of Pi is in their uses of different narrative levels. While the novel has an unnamed =author? who presents the story to the readers, the film has an implicit director who leaves =clues? of which version of Pi?s story is ?real? in the context of the narrative. This difference gives to the novel an open end, facein which the readers must choose which version of the story they believe in, while the film presents a resolution to this question. The film, thus, can be understood as a testimony narrative, a narrative of the trauma of a survivor from a shipwreck and from the experience of migration, while the novel does not decide for one of the versions of the story, enabling a more inconclusive reading
A Limited Role for PI(3,4,5)P-3 Regulation in Controlling Skeletal Muscle Mass in Response to Resistance Exercise
No full textBackground: Since activation of the PI3K/(protein kinase B; PKB/akt) pathway has been shown to alter muscle mass and growth, the aim of this study was to determine whether resistance exercise increased insulin like growth factor (IGF) I/ phosphoinositide 3-kinase (PI3K) signalling and whether altering PI(3,4,5)P3 metabolism genetically would increase load induced muscle growth. Methodology/Principal Findings: Acute and chronic resistance exercise in wild type and muscle specific PTEN knockout mice were used to address the role of PI(3,4,5)P3 regulation in the development of skeletal muscle hypertrophy. Acute resistance exercise did not increase either IGF-1 receptor phosphorylation or IRS1/2 associated p85. Since insulin/IGF signalling to PI3K was unchanged, we next sought to determine whether inactivation of PTEN played a role in load-induced muscle growth. Muscle specific knockout of PTEN resulted in small but significant increases in heart (PTEN+/+ = 5.00±0.02 mg/g, PTEN-/- = 5.50±0.09 mg/g), and TA (PTEN+/+ = 1.74±0.04 mg/g, PTEN-/- = 1.89 ±0.03) muscle mass, while the GTN, SOL, EDL and PLN remain unchanged. Following ablation, hypertrophy of the PLN, SOL or EDL muscles was similar between PTEN-/- and PTEN+/+ animals. Even though there were some changes in overload-induced PKB and S6K1 phosphorylation, 1 hr following acute resistance exercise there was no difference in the phosphorylation state of S6K1 Thr389 between genotypes. Conclusions/Significance: These data suggest that physiological loading does not lead to the enhanced activation of the PI3K/PKB/mTORC1 axis and that neither PI3K activation nor PTEN, and by extension PI(3,4,5)P3 levels, play a significant role in adult skeletal muscle growth
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2018 Interview with William Mackenzie
No full textNational Science Foundation (BCS1500220). Collaborative Research: An Audio-visual corpus of Scottish Gaidhlig (GLA). PI: Carnie. Co PIs: Hammond, Fisher. Collaborative proposal with Ian Clayton at the University of Nevado Reno.This item is part of the University of Arizona Celtic Linguistics Project, made available by the University of Arizona Scottish Gaelic Phonology and Phonetics group and the University of Arizona Libraries. Please contact us at [email protected] for more information
As duas primeiras praças de Teresina/PI: análise de suas transformações no tempo e diagnóstico
No full textO presente trabalho busca analisar conceitos e reflexões de projeto das Praças Marechal Deodoro e Saraiva,
localizadas em Teresina-PI, partindo da recomposição e entendimento do processo de evolução urbana das áreas no
contexto da cidade desde suas fundações aos dias de hoje. Com isso pretende-se ao final contribuir com um diagnóstico
para a requalificação das praças e seu entorno, colaborando, assim, na qualidade espacial da cidade e numa melhor
apropriação desse território pela população. Para tal, a pesquisa baseia-se, principalmente, no conceito de Morfologia da
Paisagem Urbana, e na dialética entre projeto, apropriação e acessibilidade dos espaços livres públicos.This study aims to examine concepts and ideas of design and the Place MarechalDeodoro Scott, located in Teresina,
Piauí, starting with the restoration and understanding of the evolutionary process of urban areas in the context of the city
from its foundation to today.With this we intend to contribute to the final guidelines for the reclassification of projective
squares and its surroundings, thus contributing, in the spatial quality of the city and a better ownership by the population of
that territory. To this end, the research is based mainly on the concept of Urban Landscape Morphology, and the dialectic
between design, ownership and accessibility of public open spaces.Fundo Mackenzie de Pesquis
Hadronic form factors and the J/psi secondary production cross section: An update
No full textImproving previous calculations, we compute the D + (D) over bar J/psi + pi cross section using the most complete effective Lagrangians available. The new crucial ingredients are the form factors on the charm meson vertices, which are determined from QCD sum rules calculations. Some of them became available only very recently, and the last one, needed for our present purpose, is calculated in this work.Univ Estadual Paulista, Inst Fis Teor, BR-01405000 São Paulo, BrazilUniv Presbiteriana Mackenzie, BR-01302907 São Paulo, BrazilUniv São Paulo, Inst Fis, BR-05315970 São Paulo, BrazilUniv Estadual Paulista, Inst Fis Teor, BR-01405000 São Paulo, Brazi
Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy
No full textNeurofibrillary tangles (NFTs) are associated with neuronal loss and correlate with cognitive impairment in Alzheimer disease, but how NFTs relate to neuronal death is not clear. We studied cell death in Tg4510 mice that reversibly express P301L mutant human tau and accumulate NFTs using in vivo multiphoton imaging of neurofibrillary pathology, propidium iodide (PI) incorporation into cells, caspase activation, and DNA labeling. We first observed that in live mice, a minority of neurons were labeled with the caspase probe or with PI fluorescence. These markers of cell stress were localized in the same cells and appeared specifically within NFT-bearing neurons. Contrary to expectations, the PI-stained neurons did not die during a day of observation; the presence of Hoechst-positive nuclei in them on the subsequent day indicated that the NFT-associated membrane disruption, as suggested by PI staining, and caspase activation do not lead to immediate death of neurons in this tauopathy model. This unique combination of in vivo multiphoton imaging with markers of cell death and pathological alteration is a powerful tool for investigating neuronal damage associated with neurofibrillary pathology
Amplitude analysis of D-0 -> K- pi(+) pi(+) pi(-)
No full textKolcu, Onur Buğra (Arel Author)Kolcu, Onur Buğra (Arel Author)We present an amplitude analysis of the decay D-0 -> K- pi(+)pi(+)pi(-) based on a data sample of 2.93 fb(-1) acquired by the BESIII detector at the psi(3770) resonance. With a nearly background free sample of about 16000 events, we investigate the substructure of the decay and determine the relative fractions and the phases among the different intermediate processes. Our amplitude model includes the two-body decays D-0 -> (K) over bar*(0)rho(0), D-0 -> K- a(1)(+) (1260) and D-0 -> K-1(-)(1270)pi(+), the three-body decays D-0 -> K-1(-)*(0)pi(+)pi(-) and D-0 -> K- pi(+)rho(0), as well as the four-body nonresonant decay D-0 -> K- pi(+)pi(+)pi(-). The dominant intermediate process is D-0 -> K(-)a(1)(+)(1260)accounting for a fit fraction of 54.6%.We present an amplitude analysis of the decay D-0 -> K- pi(+)pi(+)pi(-) based on a data sample of 2.93 fb(-1) acquired by the BESIII detector at the psi(3770) resonance. With a nearly background free sample of about 16000 events, we investigate the substructure of the decay and determine the relative fractions and the phases among the different intermediate processes. Our amplitude model includes the two-body decays D-0 -> (K) over bar*(0)rho(0), D-0 -> K- a(1)(+) (1260) and D-0 -> K-1(-)(1270)pi(+), the three-body decays D-0 -> K-1(-)*(0)pi(+)pi(-) and D-0 -> K- pi(+)rho(0), as well as the four-body nonresonant decay D-0 -> K- pi(+)pi(+)pi(-). The dominant intermediate process is D-0 -> K(-)a(1)(+)(1260)accounting for a fit fraction of 54.6%
Recommended from our members
2018 Interview with Murdo Alec Mackenzie
No full textNational Science Foundation (BCS1500220). Collaborative Research: An Audio-visual corpus of Scottish Gaidhlig (GLA). PI: Carnie. Co PIs: Hammond, Fisher. Collaborative proposal with Ian Clayton at the University of Nevado Reno.This item is part of the University of Arizona Celtic Linguistics Project, made available by the University of Arizona Scottish Gaelic Phonology and Phonetics group and the University of Arizona Libraries. Please contact us at [email protected] for more information
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