762 research outputs found
The history of the clemency of our English monarchs [electronic resource] : The usage prisoners, who surrender'd at discretion, have met with from their hands. Compar'd with several matters of fact which have lately occurr'd in this kingdom. With an Account of the Manner of issuing forth Acts of Grace and Pardon in former Reigns. Written for the Information of the present Age, and of Posterity. By M. E.
No full textM. E. = Matthias Earbery.In this issue, there are commas after "prisoners" and "discretion" on the titlepage, and an errata slip stuck over the printer's ornament on p.88.Electronic reproduction.English Short Title Catalog,Reproduction of original from British Library
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'A daughter come home?': the travel writings of Colleen J. McElroy
No full textAromatic amino acids at the surface of InlB are essential for host cell invasion by Listeria monocytogenes
No full textMachner MP, Frese S, Schubert WD, et al. Aromatic amino acids at the surface of InlB are essential for host cell invasion by Listeria monocytogenes. Mol Microbiol. 2003;48(6):1525-1536
Editorial: Biology and Pathogenesis of Legionella
No full textLegionella pneumophila was first isolated as the causative agent of a deadly infectious pneumonia at a convention of the American Legion forty years ago. Since then, Legionnaires’ disease continues to be a significant public health concern. Today, our understanding of the Legionella genus, comprising environmental bacteria and opportunistic human pathogens, has dramatically increased. The study of how pathogenic Legionella interact with host cells, both protozoan and mammalian, has not only taught us about host-pathogen interactions but has revealed novel and unexpected insights into human cell biology and immunology. The capacity of pathogenic Legionella to commandeer cellular processes such as eukaryotic vesicular trafficking to establish an ER-like replicative niche, reflects the exquisite ability of this pathogen to manipulate eukaryotic cell biology in order to replicate in an intracellular compartment. This requires the specific and targeted action of a cohort of translocated bacterial effector proteins. In addition, we have learnt much about cell autonomous innate immune sensing of intracellular bacteria through the inability of L. pneumophila to avoid intracellular mammalian defense mechanisms. Now, in the age of large-scale comparative “omics”, it is clear that different Legionella species utilize different cohorts of effectors to replicate inside eukaryotic cells. While we understand some of the strategies employed by L. pneumophila and L. longbeachae to replicate within eukaryotic cells, there is still much to learn about many aspects of the Legionella life cycle. This Research Topic highlights the latest findings regarding the biology of Legionella species, their interactions with eukaryotic host cells, and how the application of various technologies has increased our understanding of this important pathogen
Script underlying the paper "On Robustly Convergent and Efficient Iterative Methods for Anisotropic Radiative Transfer"
No full text*** Solver for anisotropic radiative transfer in an XY-geometry ***
authors: J. Dölz, O. Palii, M. Schlottbom
corresponding author: Matthias Schlottbom, University of Twente, [email protected]
*** Scientific reference ***
Jürgen Dölz, Olena Palii, Matthias Schlottbom
On robustly convergent and efficient iterative methods for anisotropic radiative transfer.
Journal of Scientific Computing 90 (94), 2022.
https://doi.org/10.1007/s10915-021-01757-9
When using this code, cite that paper.
*** Description ***
For using the code, unzip the repository and run solve.m.
In lines 4-12, there are parameters regarding the solver and meshes used.
In line 51, a function is called that specifies the optical parameters.</p
Targeting of Host Rab GTPase Function by the Intravacuolar Pathogen Legionella pneumophila
No full textSummaryThe intracellular pathogen Legionella pneumophila replicates in a vacuole that recruits material from the host cell endoplasmic reticulum (ER). Biogenesis of this unique vacuole depends on the bacterial Dot/Icm type IV secretion system that translocates proteins across host cell membranes. Here, we show that two translocated substrates, SidM and LidA, target host cell Rab1, a small GTPase regulating ER-to-Golgi traffic. SidM is a guanosine nucleotide exchange factor for Rab1 that recruits Rab1 to Legionella-containing vacuoles, a process that is enhanced by LidA. Expression of sidM in mammalian cells interferes with the secretory pathway and causes Golgi fragmentation. Consistent with a collaborative relationship between the two proteins, immobilized SidM and LidA synergize to promote Rab1-dependent binding of early secretory vesicles. These results indicate that proteins translocated into the host cell by the intravacuolar pathogen L. pneumophila are able to recapitulate events involved in host secretory trafficking
Exploitation of the host cell ubiquitin machinery by microbial effector proteins
No full textABSTRACT
Pathogenic bacteria are in a constant battle for survival with their host. In order to gain a competitive edge, they employ a variety of sophisticated strategies that allow them to modify conserved host cell processes in ways that favor bacterial survival and growth. Ubiquitylation, the covalent attachment of the small modifier ubiquitin to target proteins, is such a pathway. Ubiquitylation profoundly alters the fate of a myriad of cellular proteins by inducing changes in their stability or function, subcellular localization or interaction with other proteins. Given the importance of ubiquitylation in cell development, protein homeostasis and innate immunity, it is not surprising that this post-translational modification is exploited by a variety of effector proteins from microbial pathogens. Here, we highlight recent advances in our understanding of the many ways microbes take advantage of host ubiquitylation, along with some surprising deviations from the canonical theme. The lessons learned from the in-depth analyses of these host–pathogen interactions provide a fresh perspective on an ancient post-translational modification that we thought was well understood.
This article is part of a Minifocus on Ubiquitin Regulation and Function. For further reading, please see related articles: ‘Mechanisms of regulation and diversification of deubiquitylating enzyme function’ by Pawel Leznicki and Yogesh Kulathu (J. Cell Sci. 130, xxxxx-xxxx). ‘Cell scientist to watch – Mads Gyrd-Hansen' (J. Cell Sci. 130, xxxxx-xxxx).</jats:p
Fifteen discourses devotional and practical : suited to the use of families , with a proper hymn annex'd to each ; to which is added, by way of appendix, an historical dissertation on the analogy between the behaviour of God's people towards him, in the several periods of the Jewish and Christian Church, and his correspondent dispensations toward them in those respective periods /
No full text"Lately published by the same author": [2] p. at end.Mode of access: Internet.BEIR Mhc9 M382 Se7 1758: Ownership inscription: Matthias Burnel's book
Script underlying the paper "On Robustly Convergent and Efficient Iterative Methods for Anisotropic Radiative Transfer"
No full text*** Solver for anisotropic radiative transfer in an XY-geometry ***
authors: J. Dölz, O. Palii, M. Schlottbom
corresponding author: Matthias Schlottbom, University of Twente, [email protected]
*** Scientific reference ***
Jürgen Dölz, Olena Palii, Matthias Schlottbom
On robustly convergent and efficient iterative methods for anisotropic radiative transfer.
Journal of Scientific Computing 90 (94), 2022.
https://doi.org/10.1007/s10915-021-01757-9
When using this code, cite that paper.
*** Description ***
For using the code, unzip the repository and run solve.m.
In lines 4-12, there are parameters regarding the solver and meshes used.
In line 51, a function is called that specifies the optical parameters.</p
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