1,721,061 research outputs found
ENROFLOXACIN THEOPHYLLINE INTERACTION - INFLUENCE OF ENROFLOXACIN ON THEOPHYLLINE STEADY-STATE PHARMACOKINETICS IN THE BEAGLE DOG
No full textEnrofloxacin, a quinolone antibiotic developed exclusively for use in animals, was investigated for its effects on the steady-state pharmacokinetics of theophylline in six healthy Beagle dogs. A sustained-release theophylline formulation was given alone (20 mg/kg per os twice daily at 12 h intervals) for 9 days and then co-administered with enrofloxacin (5 mg/kg i.v, once a day) for 5 days. Mean trough theophylline concentrations progressively and significantly increased during the five days of enrofloxacin co-administration. Theophylline clearance and concentration-time profile were significantly changed by enrofloxacin co-administration. No significant change was observed in enrofloxacin pharmacokinetics, The kinetic interaction between theophylline and enrofloxacin could be of clinical significance and may require plasma drug concentration monitoring and adjustment of theophylline dosage
Comparative bioavailability of two sustained - release theophylline formulations after multiple oral doses in the dog
No full textFarmacocinetica della teofillina nel cane dopo somministrazione protratta con una preparazione a lento rilascio: interferenze con un trattamento con enrofloxacina
No full textEquine cushing-like syndrome: diagnosis and therapy in two cases
No full textEquine Cushing-like syndrome or Hyperadrenocorticism is caused by excessive secre- tion of ACTH by the pituitary gland, secondary bilateral adrenocortical hyperplasia and associated hypercortisolemia. Equine Cushing-like syndrome is due to hyperpla- sia or adenoma formation of the pituitary pars intermedia. A possible cause is the reduction of negative regulation of dopamine on ACTH secretion because of a hypo- thalamic disease (Dybdal, 1997). Considering this etiopathogenesis a more appro- priate description of the disease is probably Pituitary Pars Intermedia Dysfunction (PPID) (Schott, 1997). PPID is relatively frequent in old horses (>18 years) with no apparent sex predisposition although authors have suggested that females are afflicted more than males (Boujon et al., 1993; Heinrichs, 1990). The characteristic clinical signs include: weight loss secondary to muscle wasting, exercise intolerance, pendu- lous abdomen, hirsutism and curly hair coat, polyuria and polydipsia, hyperhydrosis, delayed wound healing (Thompson et al., 1995) and bulging supraorbital fat pads as a result of fat redistribution.
Less frequent symptoms are skin infections, urinary tract infections, gingivitis, periodontal infections, bronchopneumonia and chronic recurrent laminitis (Hillyer et al. 1992; Reed, 1998). Persistent hypercortisolism induces insulin resistance and associated glucose intolerance, thus hyperglycemia and hyperinsulinemia are possible (Beech e Garcia, 1985; Beech, 1987; Reed, 1998). Furthermore, infertility seems to be a common consequence of releasing inhibition of gonadothropic hormones (Love, 1993)
SINDROME DI CUSHING EQUINA- RISOLUZIONE DELLA SINTOMATOLOGIA IN 2 SOGGETTI TRATTATI CON PERGOLIDE
No full textRapid Determination of the Blood Level of Psycotic Drugs
No full textSimultaneous determination of several psycotic drugs in blood in a short time
The treatment of patients suffering from different types of psychiatric problems is often carried out administrating them with mixtures of more psycotic drugs. This procedure arises from several considerations. First, usually this kind of drugs suffers from different grades of side effects, so that it is a common procedure to face them by administrating complementary drugs. Moreover the psychiatric disorders themselves are often a mixture of different states, depressive, obsessive, convulsive, anxious, etc., and specific action drugs are used to fight any of these states. Unfortunately the mixtures are normally used as a sum without taking into account possible interactions inside the organism. On top of that, sometimes it is important to check the effective assumption of the drugs.
Most of the drugs taken into account in the present investigation are basic, so that positive electrospray has been chosen as ionization technique. The different compounds have been separately optimized and the best transition and source parameters have been found for each of them: nicotine (163-132), caffeine (195-138), carbamazepine (237-194), amitriptyline (278-233), imipramine (281-86), sertraline (306-275), alprazolam (309-281), fluoxetine (310-44), clomipramine (315-86), fluvoxamine (319-71), clozapine (327-270), and paroxetine (330-192). The HPLC separation have been carried out by a Phenomenex Synergi POLAR 2x50 mm, 4 &mum particle size, using a gradient water/acetonitrile/ammonium acetate/formic acid in 4 min.
The separation of the 12 drugs reavealed quite challenging. Several HPLC columns and mobile phase conditions were tested. Finally the use of a phenyl ether with polar endcapping stationary phase allowed a reasonsable separation in a short time. The use of a partially buffered mobile phase (ammonium acetate is present only in the water component) allowed to retain nicotine and caffeine for about 2 minutes inside the HPLC column. The use of the only formic acid as a modifier causes the elution of the nicotine with the solvent front and the caffeine shortly after, in a region suffering fron high suppression effects. The use of the only ammonium acetate as a modifier causes much longer analysis times. The study of matrix effects has been performed on serum and plasmas containing different anticoagulant agents. The results obtained have been compared and evalued and experiments on spiked real samples are currently in progress
Long term therapy with a new liquid L-thyroxine preparation: bioequivalence with L-T4 tablets
No full textCushing-like syndrome: Diagnosis and therapy in two cases
No full textTwo case of Cushing-like syndrome has been reported. The diagnosis has been made on suggestive clinical signs and diagnostic tests (haemathological and biochemical profiles, ACTH plasma concentrations, ACTH stimulation test and insulin plasma concentrations). In both cases, pergolide 3 mg/horse PO has been used for treatment. Both horses recovered well without significant side effects. After 18 months of therapy the horses are still in therapy
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