54 research outputs found
UEG899225 Supplemental Material - Supplemental material for Prevalence of coexisting autoimmune thyroidal diseases in coeliac disease is decreasing
No full textSupplemental material, UEG899225 Supplemental Material for Prevalence of coexisting autoimmune thyroidal diseases in coeliac disease is decreasing by Patricia Dominguez Castro, Grace Harkin, Mary Hussey, Brian Christopher, Clifford Kiat, Jun Liong Chin, Valerie Trimble, Deirdre McNamara, Padraic MacMathuna, Brian Egan, Barbara Ryan, David Kevans, Mohamed Abuzakouk, Richard Farrell, Con Feighery, Valerie Byrnes, Nasir Mahmud and Ross McManus in United European Gastroenterology Journal</p
Long read review: The new poverty by Stephen Armstrong
No full textCoinciding with the 75th anniversary of the Beveridge Report and written in the spirit of George Orwell’s The Road to Wigan Pier, The New Poverty takes a tour of contemporary Britain to show how the implementation of austerity has worked to impoverish millions and leave millions more close to crisis. The combination of reportage and statistics presented by author Stephen Armstrong offers compelling, evocative and dismaying insight into the true, intolerable cost of poverty in the UK today, finds Padraic X. Scanlan
Long read review: the new poverty by Stephen Armstrong
No full textCoinciding with the 75th anniversary of the Beveridge Report and written in the spirit of George Orwell’s The Road to Wigan Pier, The New Poverty takes a tour of contemporary Britain to show how the implementation of austerity has worked to impoverish millions and leave millions more close to crisis. The combination of reportage and statistics presented by author Stephen Armstrong offers compelling, evocative and dismaying insight into the true, intolerable cost of poverty in the UK today, finds Padraic X. Scanlan
Matthew Arnold’s "Magic Qualities in Celtic Literature" Applied to Poetry of Mr. Padraic Colum
No full textA promising development,in recent literature is a movement known as the Irish Literary Revival. Begun in the last quarter of the nineteenth century, this movement progressed rapidly and has already made notable contributions to contemporary Catholic literature. The first work to attract widespread attention was Poems and Ballads of Young Ireland. This collection appeared in 1888 and was succeeded by other works of a high literary value. |Among the writers in the modern Irish Literary Revival, one of the most important poets and one of its best dramatists is Mr. Padraic Colum. Besides poems and dramas, this author has written sketches, novels, essays, criticisms, descriptions, fairy stories, studies in folklore, all of them manifestations of a rich and fertile mind. Although our author is skilled at all types, it is in his poetry that the comprehensiveness of the poet's vision, the ecstasy and concentration of his message lies. In his poems chiefly we find that magic and charm of the Celt. |It is our purpose in this work to show how the magic and charm attributed by Matthew Arnold to the Celt is brought out in the works of the poet we have selected, Mr. Padraic Colum. We feel that any information which the writer has obtained through personal communication, study of the poems, criticisms, and conversations with such as know the Irish customs and habits will be of interest to our readers. |The chapter following this introduction will deal with Celtic poetry as described by Matthew Arnold in his criticisms showing the literary virtues and characteristics of the Celt, especially his magic and charm. Chapter two will include a brief biography of Mr. Padraic Colum and the influence his life and environment have had on his writings. The greater portion of this study, however, will consist of an attempt to interpret Mr. Padraic Colum's poems in the light of their magic and charm. A chapter will be devoted to each group of poems: Dramatic Legends. Wild Earth. Other Lands and Seas. Creatures, and Old Pastures.ProQuest Traditional Publishing Optio
In Silico Promoter Analysis can Predict Genes of Functional Relevance in Cell Proliferation: Validation in a Colon Cancer Model
No full textSpecific combinations of transcription-factor binding sites in the promoter regions of genes regulate gene expression, and thus key functional processes in cells. Analysis of such promoter regions in specific functional contexts can be used to delineate novel disease-associated genes based on shared phenotypic properties. The aim of this study was to utilize promoter analysis to predict cell proliferation-associated genes and to test this method in colon cancer cell lines. We used freely-available bioinformatic techniques to identify cell-proliferation-associated genes expressed in colon cancer, extract a shared promoter module, and identify novel genes that also contain this module in the human genome. An EGRF/ETSF promoter module was identified as prevalent in proliferation-associated genes from a colon cancer cDNA library. We detected 30 other genes, from the known promoters of the human genome, which contained this proliferation-associated module. This group included known proliferation-associated genes, such as HERG1 and MCM7, and a number of genes not previously implicated in cell proliferation in cancer, such as TSPAN3, Necdin and APLP2. Suppression of TSPAN3 and APLP2 by siRNA was performed and confirmed by RT-PCR. Inhibition of these genes significantly inhibited cell proliferation in colon cancer cell lines. This study demonstrates that promoter analysis can be used to identify novel cancer-associated genes based on shared functional processes.Cancer Research IrelandThe journal is out of print. Publisher taken over by Sage. Copyright for Journal is with Sage. Journal is licensed under Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 - A
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Constitutional law /
No full text"The fifth edition of Constitutional Law represents a significant update of the fourth edition, published in 2013. During this period, the Supreme Court of Canada has continued to develop the jurisprudence in all areas of constitutional law, including freedom of association, equality rights, Indigenous title, and inter-jurisdictional immunity. This book includes the complete text of the Canadian Constitution, including explanatory footnotes as consolidated by the federal Department of Justice. Professor Monahan authored the first three editions of this text, and invited Mr. Byron Shaw to join him as a co-author for the fourth edition. Mr. Padraic Ryan has now joined in this most recent revision. As with earlier editions, the aim of this text is to provide lawyers, academics, and law students with a general introduction to, and overview of, the basic elements of the Canadian Constitution. The authors discuss issues in sufficient detail so that the book will be of value to lawyers who encounter constitutional issues in their daily practice. Constitutional Law has been cited with approval by provincial and territorial appellate courts, as well as by the Supreme Court of Canada."-
Exiles a play in 3 acts, including hitherto unpublished notes by the author, discovered after his death, and an introduction by Padraic Colum
No full text<it>In silico </it>gene expression analysis – an overview
No full textAbstract Efforts aimed at deciphering the molecular basis of complex disease are underpinned by the availability of high throughput strategies for the identification of biomolecules that drive the disease process. The completion of the human genome-sequencing project, coupled to major technological developments, has afforded investigators myriad opportunities for multidimensional analysis of biological systems. Nowhere has this research explosion been more evident than in the field of transcriptomics. Affordable access and availability to the technology that supports such investigations has led to a significant increase in the amount of data generated. As most biological distinctions are now observed at a genomic level, a large amount of expression information is now openly available via public databases. Furthermore, numerous computational based methods have been developed to harness the power of these data. In this review we provide a brief overview of in silico methodologies for the analysis of differential gene expression such as Serial Analysis of Gene Expression and Digital Differential Display. The performance of these strategies, at both an operational and result/output level is assessed and compared. The key considerations that must be made when completing an in silico expression analysis are also presented as a roadmap to facilitate biologists. Furthermore, to highlight the importance of these in silico methodologies in contemporary biomedical research, examples of current studies using these approaches are discussed. The overriding goal of this review is to present the scientific community with a critical overview of these strategies, so that they can be effectively added to the tool box of biomedical researchers focused on identifying the molecular mechanisms of disease.</p
Endoscopic pneumatic dilation versus botulinum toxin injection in the management of primary achalasia
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