1,720,960 research outputs found
Jen Morgan Interview I, June 17, 2013
No full textAssociate Director of the Eugene Bell Center for Regenerative Biology and Tissue Engineering, Jennifer Morgan, speaks about her early experiences at the Marine Biological Laboratory and the impact that the institution has made upon her career.This video is presented in HD 720p resolutionvide
Understanding regeneration at different scales.
Get PDF© The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in MacCord, K., & Maienschein, J. Understanding regeneration at different scales. Elife, 8, (2019):e46569, doi:10.7554/elife.46569.Regeneration occurs at many different levels in nature, from individual organisms (notably earthworms and hydra), through communities of microbes, to ecosystems such as forests. Researchers in the life sciences and the history and philosophy of science are collaborating to explore how the processes of repair and recovery observed at these different scales are related.James S. McDonnell Foundatio
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
John Dowling discusses George Wald and H. Keffer Hartline
No full textHarvard University professor, John Dowling, discusses the Nobel prize-winning research of George Wald and H. Keffer Hartline, as well as their associations with the MBL.This video is presented in HD 720p resolution.vide
Explaining regeneration: cells and limbs as complex living systems, learning from history
Get PDF© The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in MacCord, K., & Maienschein, J. Explaining regeneration: cells and limbs as complex living systems, learning from history. Frontiers in Cell and Developmental Biology, 9, (2021): 734315, https://doi.org/10.3389/fcell.2021.734315.Regeneration has been investigated since Aristotle, giving rise to many ways of explaining what this process is and how it works. Current research focuses on gene expression and cell signaling of regeneration within individual model organisms. We tend to look to model organisms on the reasoning that because of evolution, information gained from other species must in some respect be generalizable. However, for all that we have uncovered about how regeneration works within individual organisms, we have yet to translate what we have gleaned into achieving the goal of regenerative medicine: to harness and enhance our own regenerative abilities. Turning to history may provide a crucial perspective in advancing us toward this goal. History gives perspective, allowing us to reflect on how our predecessors did their work and what assumptions they made, thus also revealing limitations. History, then, may show us how we can move from our current reductionist thinking focused on particular selected model organisms toward generalizations about this crucial process that operates across complex living systems and move closer to repairing our own damaged bodies.This article was a product of the McDonnell Initiative at the Marine Biological Laboratory. The McDonnell Initiative began with support from two generous grants from the James S. McDonnell Foundation, along with substantive input from the Foundation Director, Susan Fitzpatrick (“Integrating the Life Sciences with the History and Philosophy of Science” JSMF Grant No. 220020480 and “Transforming Discovery: Historians, Philosophers, and Life Scientists Exploring Regeneration” JSMF Grant No. 220020480.01)
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
How Does Germline Regenerate?
Get PDFA concise primer that complicates a convenient truth in biology—the divide between germ and somatic cells—with far-reaching ethical and public policy ramifications.
Scientists have long held that we have two kinds of cells—germ and soma. Make a change to germ cells—say using genome editing—and that change will appear in the cells of future generations. Somatic cells are “safe” after such tampering; modify your skin cells, and your future children’s skin cells will never know. And, while germ cells can give rise to new generations (including all of the somatic cells in a body), somatic cells can never become germ cells. How did scientists discover this relationship and distinction between somatic and germ cells—the so-called Weismann Barrier—and does it actually exist? Can somatic cells become germ cells in the way germ cells become somatic cells? That is, can germ cells regenerate from somatic cells even though conventional wisdom denies this possibility? Covering research from the late nineteenth century to the 2020s, historian and philosopher of science Kate MacCord explores how scientists came to understand and accept the dubious concept of the Weismann Barrier and what profound implications this convenient assumption has for research and policy, from genome editing to stem cell research, and much more
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Edmund Beecher Wilson Exhibit Poster
No full textPoster for the Edmund Beecher Wilson digital exhibit, housed on the MBL History Project websiteIllustration
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