171,980 research outputs found
Concorso internazionale per la riqualificazione della base di sottormarini Keroman a Lorient - progetto menzionato
No full textProgetto per la riconversione del patrimonio architettonico costituito della base di sottomarini Keroman, parte del complesso sistema difensivo tedesco sulla costa altlantica durante la seconda guerra mondiale. Il progetto prevede la riqualificazione degli elementi architettonici e del territorio circostante della penisola di Keroman nella città di Lorient (FR). Il concorso ha visto la partecipazione di 192 progetti, Il progetto ha ottenuto una menzione speciale (7° classificato). Gruppo di Progettazione: N. Privileggio (capogruppo), C. Macchi Cassia, P. Macchi Cassia, M. Orsini, M. Secchi
In.fra Lombardia. Il nord Milano: infrastrutture e immagini per una città lineare
No full textIl volume presenta il contributo della unità di ricerca del Politecnico di Milano, coordinata da C. Macchi Cassia, alla ricerca nazionale Murst - Forme insediative e infrastrutture. Procedure, criteri e metodi per il progetto. (1999-2001)
Sub-Saharan Cities under Climate Change. Exploring the adaptive capacity of peri-urban settlements in coastal Dar es Salaam, Tanzania
No full textOBJECTIVES
• Evaluate the results of the audit exercise on the adaptive capacity of peri-urban households and institutions;
• Provide an opportunity for sharing information and exchanging ideas among researchers, and stimulating initiatives for international networking.
DRIVING QUESTIONS
• How to assess people’s capacity to adapt to environmental change in peri-urban areas of Sub-Saharan cities?
• How to assess local institutions’ capacity to support peri-urban people in their effort to respond to environmental change?
PARTICIPANTS
a) Invitees:
1. Prof. Rui DA MAIA, Universidade Técnica de Moçambique, Mozambique
2. Prof.Enrico FONTANARI, IUAV, Italy
3. Dr.Emmanuel C. KIPKORIR, Moi University, Kenya
4. Prof Laura LIETO, Università Federico II, Italy
5. Dr.John M. LUPALA, Ardhi University, United Republic of Tanzania
6. Prof .Gabriella ROSSETTI, University of Ferrara, Italy
7. Prof.David SIMON, Royak Holloway, University of London, United Kingdom
b) From SAPIENZA University team:
1. Prof.Silvia MACCHI, Project coordinator
2. Ms.Laura FANTINI, Project manager
3. Dr.Liana RICCI, Junior researcher
4. Ms.Margherita LODDONI, PhD student
c) From ARDHI University team:
1. Prof.Gabriel KASSENGA, Local project coordinator
2. Dr.Stephen MBULIGWE, Senior researcher
3. Mr.Benedict MALELE, PhD student
4. Mr.Dionis RUGAI, Junior researcher
5. Mr.Ngalya LUKUBA ,Junior researcher
6. Mr.Alfred MWENISONGOLE
d) From DCC:
1. Mr.Phillip MWAKYUSA (City Planner)
2. Ms.Martha MKUPASI (Planning Officer
X MILANO: indizi di uno scenario possibile
No full textpresentazione, in occasione della mostra "periferie e nuove urbanità" presso la Triennale di Milano, del lavoro di ricerca sul rapporto infrastrutture ed insediamenti nell'area milanese, svolto nel triennio 1998-2001 dal gruppo di lavoro coordinato da C. Macchi Cassia e composto da M. Orsini, N. Privileggio e M. Secchi. Il lavoro è stato svolto nell'ambito della ricerca nazionale MURST, Forme insediative e infrastrutture. Procedure, criteri e metodi per il progetto, coordinatore nazionale A. Isola, con il contributo della Provincia di Milan
New Chiral Nitrogen Ligands Based on Amines Derived from -Pinene
No full textThe number of applications of bis-imines as ligands in homogeneous catalysis has much increased in recent years. Derivatives of acenaphthenequinone (R-BIAN) are especially useful for their chemical stability and rigidity. Until recently only Ar-BIAN ligands in which the aryl group contained electrondonating or moderately electronwithdrawing groups were known. We have recently expanded the available range of derivatives to ligands where the aryl group bears strongly electronwithdrawing substituents,1 two different aryl groups are present,2 and even to Alkyl-BIAN compounds.3,4 The latest had never been isolated before because an isomerization reaction occurred leading to their decomposition. We identified the cause of the decomposition in the ring strain of the five-membered ring of the acenaphthene moiety, which is partly released upon isomerization of the C=N double bond. The problem could be solved by employing ring-strained amines, for which this isomerization is thermodinamically unfavorable.3,4 Here we report the synthesis of a chiral cyclopropylamine derived from enantiomerically pure -pinene. The amine was obtained in good yields in four diastereomers. These can be separated by column chromatography. Two isomers are most abundant. One of them was employed in the synthesis of the corresponding BIAN derivative.
[1] Gasperini, M.; Ragaini, F.; Cenini, S. Organometallics, 2002, 21, 2950.
[2] Gasperini, M.; Ragaini, F.; Gazzola, E.; Caselli, A.; Macchi, P. Dalton Trans., 2004, 3376.
[3] Ragaini, F. ; Gasperini, M.;. Gallo, E.; Macchi, P. Chem. Commun., 2005, 1031.
[4] Ragaini, F.; Gasperini, M.; Parma, P.; Gallo, E.; Casati, N.; Macchi, P. New J. Chem. 2006, 30, 1046
Protocol to evaluate the impact of murine MCT1-deficient CD8+ T cells on adipogenesis
No full textSummary: The infiltration of activated T cells, such as CD8+ effector, in metabolic tissues plays a crucial role for the initiation and propagation of obesity-induced inflammation. Given the pivotal role of lactate transporter monocarboxylate transporter 1 (MCT1) in immune cell activation, we present a protocol for the isolation and activation of CD8+ T lymphocytes selectively lacking MCT1. We describe steps for the induction of adipocyte differentiation, CD8+ T isolation and activation, and adipocyte-CD8+ T cell co-culture. We then detail qPCR analysis on differentiated adipocytes.For complete details on the use and execution of this protocol, please refer to Macchi et al.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics
Multinational Corporations' Economic and Human Rights Impacts on Developing Countries: A Review and Research Agenda
No full textCriticaly of kyphoplasty and vertebroplasty
No full textKyphoplasty and vertebroplasty are minimally invasive techniques to treat vertebral compression fractures, now considered as implying relative risks and being equally effective. A few considerations must anyway be made due to some unresolved problem
Amination of C-H Bonds by Metal Porphyrins Catalysed Nitrene Transfer Reaction
No full textThe biological and pharmaceutical activities of organonitrogen compounds prompted the scientific community to develop new methods for the direct and selective C-N bond formation, working within restricted financial parameters and environmentally friendly requirements.In the last few years we have reported on the catalytic activity of metal porphyrin complexes in a wide range of reactions, such as olefin epoxidation,1 hydrocarbon amination and olefin aziridination. For these last reactions arylazides, a versatile class of starting material, was employed as atom-efficient aminating agents.2 ArN3 generate a nitrene functionality “ArN” and the eco-friendly molecular nitrogen is the only side product.
The selective insertion of “ArN” into C–H bonds of benzylic substrates or olefins yields benzylic amines, benzylic imines or allylic amines. To clarify the mechanism of the C-H amination reactions, the ruthenium bis-imido porphyrin complex (1) was isolated and characterised by X-ray analysis.
The role of 1 in catalytic nitrene insertions into C H bonds was studied in the reaction of ArN3 with several hydrocarbons proving that 1 is an active reaction intermediate. It also appears to have equilibrium between stability and reactivity.3 To the best of our knowledge, complex 1 is the first structurally characterized bis-imido porphyrin complex that shows a good catalytic activity in this class of reactions.
References: [1] S. Fantauzzi, E. Gallo, E. Rose, N. Raoul, A. Caselli, S. Issa, F. Ragaini, S. Cenini, Organometallics , 2008, 27, 6143; [2] For a review see: S. Fantauzzi, A. Caselli and E. Gallo, Dalton Trans., 2009, 5434; [3] S. Fantauzzi, E. Gallo, A. Caselli, F. Ragaini, N. Casati, P. Macchi and S. Cenini Chem. Commun., 2009, 3952–395
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