1,720,973 research outputs found
ASCORBATE-LINKED NANOSYSTEMS FOR BRAIN DELIVERY
No full textThe invention is based, at least in part, on the discovery of a method for targeting liposomes and micelles to brain cells. This discovery was exploited to develop the invention, which, in one aspect, features a method of delivering a lipid formulation to brain cell, comprising contacting the brain cell with lipid formulation, the lipid formulation comprising ascorbate or an ascorbate derivative on an outer surface of the lipid formulation, the ascorbate or the ascorbate derivative contacting a sodium-dependent vitamin C transporter (SVCT) on the brain cell to thereby deliver the lipid formulation to the brain cell. In certain embodiments, the lipid formulation is a liposome or micelle. In particular embodiments, the ascorbate linked to the liposome or micelle is not bound by a glucose transporter (GLUT), or has reduced binding capacity to GLUT relative to free ascorbate.
In some embodiments, the liposome or micelle comprises a phospholipid conjugated to the ascorbate or the ascorbate derivative at the C6 position of the ascorbate or the ascorbate derivative. In some embodiments the phospholipid comprises derivatized phospholipids. In particular embodiments the derivatized phospholipid comprises polyethylenglycol (PEG). In certain embodiments the ascrobate or ascorbate derivative is conjugated to the derivatized phospholipid via PEG. In some embodiments, the brain cell is an epithelial cell of the choroid plexus or an ependymal cell of the blood brain barrier. In some embodiments the brain cell trasports the liposome or micelle into the cerebrospinal fluid (CSF) of the brain. In other embodiments, after entering the CSF, the liposome or micelle contacts a second brain cell. In particular embodiments the second brain cell is a neuron, a glial cell, or an astrocyte or a brain turmor cell.
In some embodiments the liposome or the micelle further comprises a therapeutic agent or a detection agent.
In other aspect the invention features a method of delivering a therapeutic agent or a detection agent to a brain cell, comprising contacting the brain cell with a lipid formulation loaded with a therapeutic agent or detection agent, and ascorbate or an ascorbate derivative on the outer surface of the lipid formulation, the ascorbate or the ascorbate derivative contacting a sodium-dependent vitamin C transporter (SVCT) on the brain cell to thereby deliver the therapeutic agent or the detection agent to the brain cell
PLGA-peripheral Benzodiazepine receptor ligand conjugates: preparation and formulation of microparticles
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
- …
