1,721,055 research outputs found
Zoledronic acid for the treatment of pregnancy-associated femoral head necrosis: A case report
Full text linkIntroduction: The management of pregnancy-associated femoral necrosis is controversial. Conservative management may eventually lead to hip replacement. Case: A 40-year-old woman developed necrosis of the left hip during her first pregnancy. Treatment with zoledronic acid three months after delivery resulted in rapid reduction of the necrotic area. The patient's second pregnancy shortly afterwards had no complications. A magnetic resonance scan three years later documented complete resolution. Conclusion: Femoral head necrosis should be suspected in the differential diagnosis of pain in pregnancy. Zoledronic acid given in the early stages prevented progression to hip arthritis in this case
Bone regeneration in the stem cell era: safe play for the patient?
No full textThe past decade has seen outstanding scientific progress in the field of stem cell (SC) research and clinical application. SCs are convenient both technically and biologically: they are easy to find and to culture and they can differentiate in virtually all tissues and even in whole organs. Induced pluripotent stem cells (iPSs) are a type of pluripotent SC generated in vitro directly from mature cells through the introduction of key transcription factors. The use of iPSs, however tantalizing, poses serious safety concerns because of their genomic instability. Recently, it has been suggested that the main mechanism of SC action relies on paracrine signals. Therefore, the secretome would be primarily responsible for SC effects. The therapeutical use of secretome is safer and more reliable and offers manufacturing, handling and transportation advantages. The authors discuss current applications of SCs with particular respect to bone regeneration stressing the possible risks that may arise from incautious employments of SCs—particularly when associated with stimulating factors. Safety issues hamper the advancement of SC-based innovative therapies and raise the need for novel standards to adequately address and rule out inconsistency and other concerns, considering the permanent nature of SC treatments. Many biological aspects concerning dose, time and site of administration are still to be elucidated. Solid clinical data and trials with long-term follow-ups are highly recommended as a means to evaluate the risk/benefit ratio of each potential intervention and to provide patients with clear and accurate information. © 2017, International League of Associations for Rheumatology (ILAR)
ESPRESSIONE DIFFERENZIALE DI CITOCHINE INFIAMMATORIE IN CELLULE OSTEOBLASTICHE TRATATE CON CICLOSPORINA A.
No full textVERONA, 21-23 OTTOBR
La ciclosporina-A e gli acidi grassi influenzano l'espressione e la produzione di M-CSF in cellule umane osteoblasto-simili
No full text
Effetti della ciclosporina A sullâ€TMespressione di YKL-40 in cellule umane osteoblasto-simili
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
ITA-SENSE - Evaluate LLMs' ability for ITAlian word SENSE disambiguation: A CALAMITA Challenge
No full textThe challenge is designed to assess LLMs' abilities in understanding lexical semantics through Word Sense Disambiguation, providing valuable insights into their performance. The idea is to cast the classical Word Sense Disambiguation task in a generative problem following two directions. Our idea is to propose two tasks: (T1) Given a target word and a sentence in which the word occurs, the LLM must generate the correct meaning definition, (T2) Given a target word and a sentence in which the word occurs, the LLM should choose from a predefined set the correct meaning definition. For T1, we compare the generated definition with respect to the correct one taken from a sense inventory, while for T2, a classical accuracy metric is used. In T1, we adopt metrics that measures the quality of the generated definition such as RougeL and the BERTscore. For CALAMITA, we test LLMs using a zero-shot setting
- …
