1,721,067 research outputs found
Effects of the inhibition of aromatic aminoacids decarboxylase on prolactin secretion in humans
No full textCarbidopa, at the dose of 250 mg. and benserazide at the dose of 125 mg,
given orally in a single dose to healthy women aged between 23 - 26
years enhance significantly serum prolactin. The effect is not shared by
two other inhibitors of AADC, namely alpha-methyl DOPA (500 mg) and
fentiazac (400 mg). The effect of benserazide is suppressed by
bromocriptine (2.5 mg) and blunted by 1-DOPA (400 mg) given orally
simultaneusly
Lack of counteracting effect of liposomes on benserazide-induced hyperprolactinemia
No full textBenserazide induces an increase of serum prolactin in man, possibly as
the result of an impairment of the dopamine effect on the pituitary
and/or on the outer median eminence caused by the inhibition on L-dopa
decarboxylase. On the other hand, liposomes obtained from bovine brain
cortex phospholipids reduced serum prolactin possibly through an effect
of phosphatidylserine on dopamine biosynthesis at the level of tyrosine
hydroxylase. Benserazide, given orally (125 mg) to 5 normal subjects,
induced an increase of serum prolactin that did not change when 300 mg
of phospholipid liposomes were given intravenously 60 min later. An
increase of L-dopa synthesis does not seen to be capable to overcome the
effects of the decarboxylase inhibition
Effetto della S-Adenosilmetionina (SAMe) su alcuni parametri endocrini, in soggetti adulti normali
No full textNo changes in serum prolactin, TSH and LH were noted when the
antidepressant s-adenosylmethionine was given i.v. to 7 normal adults of
both sexes. It would thus appear that the drug's antidepressant effect
is not mediated by TSH. The results obtained are not comparable with
those observed by other workers in the rat
Dose and sex related effects of aromatic aminoacids decarboxylase inhibitors on serum prolactin in humans
No full textSingle doses of carbidopa and benserazide, two inhibitors of aromatic
aminoacids decarboxylase, have been given orally to healthy women and
men aged 19 to 32 years. Serum prolactin levels increased in respect to
baseline levels when 80, 125 or 250 mg of carbidopa and 10, 20, 30, 50,
80 or 125 mg of benserazide were given. The carbidopa doses of 20 and
50 mg were ineffective. Carbidopa induced the enhancement of serum
prolactin at a later time and over a longer time span than benserazide.
The effect on serum prolactin is dose dependent for both drugs. The
hyperprolactinaemia obtained with 250 mg of carbidopa and with 125 mg of
benserazide is significantly larger in women than in age matched men.
The observed prolactin increase fits with the hypothesis that a
diminution of the inhibitory effect of dopamine at the pituitary and/or
at the median eminence levels may occur in connection to the
pharmacologically impaired monoamine synthesis. An effect of serotonin
cannot, however, be excluded
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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